☆ 4.6 Review

The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota-gut-brain axis perspective

JOURNAL OF PHYSIOLOGY-LONDON (2023)

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The Role of Beta-Adrenergic Receptors in Depression and Resilience

Hongxing Zhang et al.

Summary: This review article discusses the role of norepinephrine in the neurobiology of major depressive disorder (MDD) and highlights the beta-adrenergic receptor subtypes based on recent preclinical and clinical studies. It introduces a new therapeutic approach involving the beta-3 adrenergic receptor to enhance stress resilience and achieve antidepressant efficacy, which is conceptually different from traditional treatments that focus on reversing pathological alterations.

BIOMEDICINES (2022)

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Article Veterinary Sciences

Stress decreases contraction of the colon, and the effects of stress are different among the regions of the colon

Naoshige Ono et al.

Summary: Stress affects gastrointestinal motility in mice, with reduced contractions in the proximal and distal colon but similar contractions in the mid colon. This regional difference may provide clues to functional abnormalities in gastrointestinal motility associated with stress.

JOURNAL OF VETERINARY MEDICAL SCIENCE (2022)

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Article Clinical Neurology

Swimming Exercise Modulates Gut Microbiota in CUMS-Induced Depressed Mice

Yumeng Xie et al.

Summary: This study suggests that swimming exercise can reverse CUMS-induced depressive behaviors and can affect the composition of gut microbiota and the regulation of microbiota metabolic pathways.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2022)

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Article Behavioral Sciences

The pathological involvement of spinal cord EphB2 in visceral sensitization in male rats

Tao Chen et al.

Summary: This study investigated the effects of post-traumatic stress disorder (PTSD) on visceral hyperalgesia and the mechanisms involved. The results showed that spinal cord EphB2 activation exacerbates visceral pain after single prolonged stress (SPS). This study provides important insights into the relationship between PTSD and chronic disorders.

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS (2022)

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Article Gastroenterology & Hepatology

Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study

Ami D. Sperber et al.

Summary: FGIDs have a high prevalence globally, especially among women. Individuals with FGIDs experience lower quality of life and require more frequent medical visits. The proportion of irritable bowel syndrome patients diagnosed using the Rome IV criteria is lower compared to the Rome III criteria.

GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

Sympathetic Input to Multiple Cell Types in Mouse and Human Colon Produces Region-Specific Responses

Kristen M. Smith-Edwards et al.

Summary: The study demonstrates that sympathetic neurons differentially regulate the activity of neurons and non-neuronal cells in the proximal and distal colon, promoting distinct changes in motility patterns. This highlights the important role of neural innervation in different regions of the colon and its significant impact on digestive health.

GASTROENTEROLOGY (2021)

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Review Neurosciences

The Acute Stress Response in the Multiomic Era

Amalie Floriou-Servou et al.

Summary: Studying the stress response is crucial in neuroscience research, with a focus on understanding the complex molecular cascades triggered by acute stressors to predict healthy or maladaptive responses.

BIOLOGICAL PSYCHIATRY (2021)

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Article Medicine, General & Internal

Management of functional gastrointestinal disorders

Asma Fikree et al.

Summary: Functional GI disorders, such as irritable bowel syndrome and functional dyspepsia, are common conditions that significantly impact quality of life and healthcare utilization. These disorders are caused by abnormalities in GI functioning. Treatment involves lifestyle and diet modifications, addressing psychological comorbidity, and medication to target underlying pathophysiology.

CLINICAL MEDICINE (2021)

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Article Cell Biology

Gut feelings about bacterial steroid-17,20-desmolase

Lindsey K. Ly et al.

Summary: Technological advances are beginning to uncover the intricate interactions between hosts and their resident microbiota, which have co-evolved over centuries. The host-associated microbiome is implicated in the production of potent androgens by generating 11 beta-hydroxyandrostenedione. Microbial steroid-17,20-desmolase is capable of cleaving the side-chain of glucocorticoids and drugs, showcasing the gut microbiome's ability to mirror the host's metabolism. Additionally, the role of intestinal steroidogenesis and efflux pumps in transporting glucocorticoids into the gut is discussed, with potential health implications for colonocytes, immune cells, and prostate cells.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2021)

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Article Biochemistry & Molecular Biology

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

Francesco Asnicar et al.

Summary: The gut microbiome is influenced by diet and has significant associations with nutrients, foods, and overall dietary habits, impacting host metabolism and cardiovascular disease risk. Certain microbial species are indicators of favorable postprandial glucose metabolism, while overall microbiome composition can predict a range of cardiometabolic blood markers.

NATURE MEDICINE (2021)

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Article Gastroenterology & Hepatology

Altered gene expression signatures by calcitonin gene-related peptide promoted mast cell activity in the colon of stress-induced visceral hyperalgesia mice

Hanliang Sun et al.

Summary: The study identified CGRP as a critical regulator of key expressed genes in MC activation. Nr4a3, as a novel regulator of MC function, may have an effect on stress-induced visceral hyperalgesia and represent a new target for drug development.

NEUROGASTROENTEROLOGY AND MOTILITY (2021)

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Article Cell Biology

Links Between Gut Dysbiosis and Neurotransmitter Disturbance in Chronic Restraint Stress-Induced Depressive Behaviours: the Role of Inflammation

Hai-long Yang et al.

Summary: This study investigated the mechanisms of depression induced by chronic restraint stress from the perspectives of inflammation, gut microbiota, and neurotransmitters. It was found that CRS led to inflammatory reactions, disturbances in neurotransmitter metabolism, and dysbiosis in gut microbiota. The study suggests potential links between microbiota dysbiosis and neurotransmitter metabolism in CRS-induced depression, providing new strategies for depression treatment.

INFLAMMATION (2021)

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Article Multidisciplinary Sciences

A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut

Yuanlong Hou et al.

Summary: The study shows that dietary raffinose metabolism to fructose couples stress-induced gut microbial remodeling to intestinal stem cell renewal and epithelial homeostasis. Dietary impact on stress and gut microbial structure and epithelial integrity could be exploited to alleviate gut disorders. Dietary modulation of microbial metabolism shapes intestinal stem cell turnover, highlighting the interplay between diet, stress, and gut health.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Chronic stress and corticosterone exacerbate alcohol-induced tissue injury in the gut-liver-brain axis

Pradeep K. Shukla et al.

Summary: This study found that chronic restraint stress exacerbates alcohol-induced gut barrier dysfunction and liver damage in mice, and these effects were reproduced by corticosterone treatment. Corticosterone amplified alcohol-induced inflammatory responses and systemic inflammation, as well as exacerbated liver damage and neuroinflammation. Additionally, corticosterone modulated alcohol-induced changes in gut microbiota diversity and abundance, which may play a crucial role in stress-induced promotion of alcohol-associated tissue injury at the Gut-Liver-Brain axis.

SCIENTIFIC REPORTS (2021)

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Article Immunology

Rifaximin-mediated gut microbiota regulation modulates the function of microglia and protects against CUMS-induced depression-like behaviors in adolescent rat

Haonan Li et al.

Summary: Rifaximin can protect against stress-induced inflammation and depressive behaviors by regulating the gut microbiome and short-chain fatty acids.

JOURNAL OF NEUROINFLAMMATION (2021)

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Article Infectious Diseases

Alleviation of Anxiety/Depressive-Like Behaviors and Improvement of Cognitive Functions by Lactobacillus plantarum WLPL04 in Chronically Stressed Mice

Xuan Sun et al.

Summary: The study demonstrated that treatment with L. plantarum WLPL04 significantly alleviated anxiety/depressive-like behaviors and cognitive deficits induced by chronic stress, restored the diversity and richness of intestinal microbiota, and maintained the levels of neurotransmitters and neurotrophic factors in the brain.

CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY (2021)

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Article Gastroenterology & Hepatology

Association Between Inflammatory Bowel Disease and Psychiatric Morbidity and Suicide: A Swedish Nationwide Population-Based Cohort Study With Sibling Comparisons

Jonas F. Ludvigsson et al.

Summary: Adult-onset inflammatory bowel disease is associated with an increased risk of psychiatric disorders and suicide attempts, particularly in the first year following diagnosis.

JOURNAL OF CROHNS & COLITIS (2021)

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Article Microbiology

Role of melatonin in murine restraint stress-induced dysfunction of colonic microbiota

Rutao Lin et al.

Summary: This study investigated the mechanisms by which melatonin (MT) mitigated stress-induced intestinal microbiota dysbiosis and inflammation, demonstrating its anti-inflammatory and antioxidant effects.

JOURNAL OF MICROBIOLOGY (2021)

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Article Endocrinology & Metabolism

Volatility as a Concept to Understand the Impact of Stress on the Microbiome

Thomaz F. S. Bastiaanssen et al.

Summary: The microbiome-gut-brain-axis is a complex phenomenon affected by stress, exhibiting volatility and influencing stress responses. The study found a significant correlation between volatility and stress response indicators, observed in different experimental groups and health volunteers, as well as demonstrating inter-species similarities on a functional level.

PSYCHONEUROENDOCRINOLOGY (2021)

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Article Psychiatry

Antidepressants fluoxetine and amitriptyline induce alterations in intestinal microbiota and gut microbiome function in rats exposed to chronic unpredictable mild stress

Weijie Zhang et al.

Summary: This study evaluated the effects of fluoxetine and amitriptyline on gut microbiota composition and function in a chronic unpredictable mild stress-induced depression rat model, finding significant alterations caused by both antidepressants on the gut microbiome.

TRANSLATIONAL PSYCHIATRY (2021)

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Article Immunology

Acute Cold Water-Immersion Restraint Stress Induces Intestinal Injury and Reduces the Diversity of Gut Microbiota in Mice

Yuan Zhang et al.

Summary: The study demonstrated that acute cold water-immersion restraint stress caused severe intestinal mucosal injury, increased inflammation, disrupted gut barrier function, and reduced gut microbiota diversity in male C57BL/6 mice. Specifically, aerobic and gram-negative bacteria significantly increased after the stress, which was associated with the severity of gut injury.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Immunology

Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis

Tuo Chen et al.

Summary: Psychological disorders are linked to a greater risk of severe inflammatory bowel disease due to disruptions in gut microbiota balance and colonic mucosal barriers. Chronic restraint stress has been shown to alter microbiota composition and colonic mucus, exacerbating colitis symptoms.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Pharmacology & Pharmacy

Shugan Hewei Decoction Alleviates Cecum Mucosal Injury and Improves Depressive- and Anxiety-Like Behaviors in Chronic Stress Model Rats by Regulating Cecal Microbiota and Inhibiting NLRP3 Inflammasome

Yingying Yue et al.

Summary: Chronic stress can lead to depression, anxiety, and intestinal mucosal injury, with gut microbiota disturbances playing a role in these disorders. A traditional Chinese medicine formula, Shugan Hewei Decoction (SHD), has been shown to effectively treat these conditions by modulating gut microbiota diversity and regulating inflammatory pathways.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Neurosciences

Fecal microbiota transplantation ameliorates gut microbiota imbalance and intestinal barrier damage in rats with stress-induced depressive-like behavior

Jingjing Rao et al.

Summary: The study demonstrated that fecal microbiota transplantation can improve depressive-like behavior in rats, alter gut microbiota imbalance, and alleviate intestinal inflammation, intestinal mucosal disruption, and neuroinflammation.

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

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Article Immunology

Prenatal Maternal Stress Exacerbates Experimental Colitis of Offspring in Adulthood

Yue Sun et al.

Summary: Prenatal maternal stress may affect the gut microbiota and neuroimmune network of offspring, resulting in impaired intestinal development and increased susceptibility.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Clinical Neurology

Puerarin ameliorates depression-like behaviors of with chronic unpredictable mild stress mice by remodeling their gut microbiota

Xujiao Song et al.

Summary: Puerarin was found to alleviate depression-like behaviors induced by chronic stress in mice, and it reversed the changes in gut microbiota characterized by pathological microbial flora. The results suggest that the antidepressant mechanism of puerarin may closely interact with restoring beneficial microflora.

JOURNAL OF AFFECTIVE DISORDERS (2021)

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Article Neurosciences

Early life adversity predicts brain-gut alterations associated with increased stress and mood

Elena J. L. Coley et al.

Summary: The study found a novel association between early-life adversity, alterations in the brain-gut axis, and increased vulnerability to negative mood and stress. Results suggest that select gut-regulated metabolites may contribute to the adverse effects of critical period stress on neural development through pathways related to glutamatergic excitotoxicity and oxidative stress.

NEUROBIOLOGY OF STRESS (2021)

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Review Clinical Neurology

Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis

Hannibal Person et al.

Summary: The brain-gut axis plays a crucial role in the comorbidity of psychological disorders and gastrointestinal diseases, with the gut microbiome being a key component. Targeting the brain-gut-microbiome axis may offer novel treatment options for addressing these debilitating diseases.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2021)

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Article Multidisciplinary Sciences

Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice

Jeon-Kyung Kim et al.

Summary: Buspirone alleviates anxiety/depression induced by stress or Escherichia coli by modulating gut microbiota, suppressing neuroinflammation, and altering microbiota composition.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model

Kosuke Suzuki et al.

Summary: This study reveals that psychological stress can decrease the secretion of alpha-defensin by Paneth cells, leading to dysbiosis and significant changes in intestinal metabolites. However, administration of alpha-defensin can help restore the balance of the intestinal ecosystem under psychological stress.

SCIENTIFIC REPORTS (2021)

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Article Environmental Sciences

Life Stressors in Patients with Inflammatory Bowel Disease: Comparison with a Population-Based Healthy Control Group in the Czech Republic

Hana Bednarikova et al.

Summary: The study found that IBD patients were more likely to report life stressors, especially those experienced before the age of 16, with higher scores in traumatic stress and interpersonal violence. Reporting life stressors is strongly associated with IBD and should be considered in disease management, especially in severe cases.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Neurosciences

Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota

Teng Ma et al.

Summary: The study indicates that probiotic supplementation can alleviate stress and anxiety by modulating gut microbiota, increasing microbial diversity, and influencing the levels of beneficial and harmful bacterial species in the gut. Additionally, probiotics also enhance the production of neurotransmitter-synthesizing/consuming species and neuroactive metabolites, supporting the involvement of the gut-brain axis in relieving stress-related symptoms.

NEUROBIOLOGY OF STRESS (2021)

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Article Immunology

Restraint Stress in Hypertensive Rats Activates the Intestinal Macrophages and Reduces Intestinal Barrier Accompanied by Intestinal Flora Dysbiosis

Tiantian Wang et al.

Summary: The results revealed that acute stress rapidly increased mean arterial pressure, especially in the SHR-stress group. Additionally, stress promoted an increase in epithelial permeability, reduction in tight junction-related protein expression, and aggregation of macrophages. Furthermore, stress led to significant increases in stress-related hormones and pro-inflammatory factor interleukin-6, along with a decrease in intestinal flora diversity and an imbalance in the F/B ratio.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Behavioral Sciences

Prenatal stress-induced disruptions in microbial and host tryptophan metabolism and transport

Jeffrey D. Galley et al.

Summary: The aromatic amino acid tryptophan is essential for immune and neurodevelopment, and prenatal stress can disrupt its metabolism and lead to reductions in tryptophan-associated microbes in both the mother and offspring. This disruption may mediate aberrant fetal neurodevelopment.

BEHAVIOURAL BRAIN RESEARCH (2021)

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Article Multidisciplinary Sciences

Short intense psychological stress induced by skydiving does not impair intestinal barrier function

Maria Fernanda Roca Rubio et al.

Summary: The study revealed that acute intense psychological stress induced by skydiving does not affect intestinal permeability in healthy subjects. Future studies aiming to investigate the effect of stress on human intestinal barrier function should consider a more sustained exposure to the psychological stressor.

PLOS ONE (2021)

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Article Gastroenterology & Hepatology

Estrogen augmented visceral pain and colonic neuron modulation in a double-hit model of prenatal and adult stress

Jing-Hong Chen et al.

Summary: The study found that female rodents have significantly higher colonic neuron activity than males, and chronic stress further increases this sensitivity. Estrogen plays an important role in this process.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

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Article Integrative & Complementary Medicine

Chaihu-Shugan-San (Shihosogansan) alleviates restraint stress-generated anxiety and depression in mice by regulating NF-κB-mediated BDNF expression through the modulation of gut microbiota

Sang-Kap Han et al.

Summary: Chaihu-Shugan-San (CSS) alleviated anxiety and depression by inducing NF-kappa B-involved BDNF expression through the regulation of gut inflammation and microbiota.

CHINESE MEDICINE (2021)

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Article Immunology

Impact of Inosine on Chronic Unpredictable Mild Stress-Induced Depressive and Anxiety-Like Behaviors With the Alteration of Gut Microbiota

Xueer Liu et al.

Summary: The study found that inosine has antidepressant and anti-anxiety effects on adolescent mice with depression, along with alterations in their fecal microbial composition. The results suggest that inosine may influence gut microbiota through carbohydrate metabolism and lipid metabolism pathways.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Review Psychiatry

Perturbations in Gut Microbiota Composition in Psychiatric Disorders A Review and Meta-analysis

Viktoriya L. Nikolova et al.

Summary: This meta-analysis found that gut microbiota perturbations were associated with a transdiagnostic pattern with a depletion of certain anti-inflammatory butyrate-producing bacteria and an enrichment of pro-inflammatory bacteria in patients with depression, bipolar disorder, schizophrenia, and anxiety.

JAMA PSYCHIATRY (2021)

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Article Psychiatry

Characterization of gut microbiome in mice model of depression with divergent response to escitalopram treatment

Jiajia Duan et al.

Summary: Depression is a common and heterogeneous mental disorder, with antidepressants like escitalopram showing different treatment responses in patients. Research has found that changes in microbial composition and metabolic functions may be related to the efficacy of these antidepressants.

TRANSLATIONAL PSYCHIATRY (2021)

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Review Psychiatry

Title: Labels Matter: Is it stress or is it Trauma?

Gal Richter-Levin et al.

Summary: In neuroscience, the term "stress" is often associated with negative consequences, but resilience is actually a more common reaction to stress. It is important to differentiate between stress conditions and trauma in research terminology, as this can impact how we understand and study stress-related pathologies and resilience mechanisms.

TRANSLATIONAL PSYCHIATRY (2021)

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Article Immunology

Consumption of Butylated Starch Alleviates the Chronic Restraint Stress-Induced Neurobehavioral and Gut Barrier Deficits Through Reshaping the Gut Microbiota

Peijun Tian et al.

Summary: The beneficial effect of short-chain fatty acids (SCFAs) on host health, especially in influencing psychological function, has been highlighted in this study. The acetylated-, butylated-, and isobutylated-starch could attenuate depression-like behaviors and reduce colonic permeability by increasing tight junction proteins gene expression and reducing inflammatory cytokines levels. The neurological and immunological benefits of butylated starch may be derived from gut microbiome modifications, suggesting potential for novel food or dietary supplements for improving mental health.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Probiotic Bifidobacterium bifidum G9-1 Has a Preventive Effect on the Acceleration of Colonic Permeability and M1 Macrophage Population in Maternally Separated Rats

Xuan Wang et al.

Summary: This study found that oral administration of the probiotic Bifidobacterium bifidum G9-1 (BBG9-1) improved colonic mucosal integrity, reduced the increase of M1 macrophages, and decreased the expression of inflammatory cytokines IL-6 and IFN-gamma in maternally separated (MS) rats modeling irritable bowel syndrome (IBS).

BIOMEDICINES (2021)

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Article Multidisciplinary Sciences

Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells

Chen Xiang et al.

Summary: Intestinal microbiota modulates catecholamine storage and secretion in mouse adrenal chromaffin cells through interactions with the Nod1 ligand, affecting adrenal responses.

ISCIENCE (2021)

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Article Multidisciplinary Sciences

Estrous cycle and ovariectomy-induced changes in visceral pain are microbiota-dependent

Monica Tramullas et al.

Summary: Through studying female mice, it was found that visceral hypersensitivity is closely related to sex hormones and gut microbiota; germ-free mice showed similar visceral pain responses to colorectal distension as conventional mice, with sensitivity not dependent on estrous cycle stage; ovariectomy induced hypersensitivity only in conventional mice, leading to weight gain.

ISCIENCE (2021)

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Article Psychiatry

CUMS and dexamethasone induce depression-like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation

Jing Wu et al.

Summary: In murine models, chronic unpredictable mild stress and dexamethasone treatment lead to changes in gut microbiota diversity, impacting brain function and causing symptoms of depression.

GENERAL PSYCHIATRY (2021)

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Article Gastroenterology & Hepatology

Social overcrowding impacts gut microbiota, promoting stress, inflammation, and dysglycemia

Clara Delaroque et al.

Summary: The study suggests that overcrowded housing may promote stress, dysbiosis of microbiota, inflammation, and metabolic diseases. Experimental evidence from mice showed that overcrowding led to changes in behavior, corticosterone levels, and gut inflammation.

GUT MICROBES (2021)

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Article Multidisciplinary Sciences

Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts

Christopher R. Shaler et al.

Summary: Psychological stress impairs gut microbiome and immune system, allowing invasive bacteria to colonize; Immune modulation and administration of certain cytokines can counteract the negative impact of stress on gut health.

NATURE COMMUNICATIONS (2021)

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Article Veterinary Sciences

Gastrointestinal motility modulation by stress is associated with reduced smooth muscle contraction through specific transient receptor potential channel

Yasu-Taka Azuma et al.

Summary: Excessive stress can lead to disability in social life and various chronic diseases. Research has shown that stress may impact gastrointestinal motility and decrease the expression of non-selective cation channels.

JOURNAL OF VETERINARY MEDICAL SCIENCE (2021)

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Review Gastroenterology & Hepatology

Investigating causality with fecal microbiota transplantation in rodents: applications, recommendations and pitfalls

Cassandra E. Gheorghe et al.

Summary: Research on the role of gut microbiota in health and diseases has significantly increased in recent years. While fecal microbiota transplantation (FMT) is beneficial in understanding this role, lack of standardization and careful experimental design are required for optimal results. Various methodological questions remain unanswered, but common pitfalls can be avoided through careful consideration in study design.

GUT MICROBES (2021)

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Article Cell Biology

Microbiota from young mice counteracts selective age-associated behavioral deficits

Marcus Boehme et al.

Summary: The study demonstrates that rejuvenation of the gut microbiome by fecal microbiota transplantation from young mice can reverse aging-induced differences in the immune system, metabolome, and transcriptome, and improve specific cognitive deficits.

NATURE AGING (2021)

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Article Gastroenterology & Hepatology

Patients' Experiences and Challenges in Living with Inflammatory Bowel Disease: A Qualitative Approach

Jelena Popov et al.

Summary: Inflammatory bowel disease (IBD) has a significant impact on patients' quality of life and imposes burdens in psychological, social, and financial aspects. Improved communication between patients and healthcare providers, family-based education approaches, individualized psychotherapy, awareness programs for stakeholders, and patient involvement in community support groups may enhance overall care for IBD patients.

CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY (2021)

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Article Biochemistry & Molecular Biology

Costunolide ameliorates intestinal dysfunction and depressive behaviour in mice with stress-induced irritable bowel syndrome via colonic mast cell activation and central 5-hydroxytryptamine metabolism

Xi Li et al.

Summary: The study showed that costunolide (COS) can alleviate intestinal dysfunction and depressive behavior in stress-induced IBS mice by inhibiting mast cell activation in the colon and regulating 5-HT metabolism in the central nervous system.

FOOD & FUNCTION (2021)

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Article Gastroenterology & Hepatology

Involvement of the microbiota-gut-brain axis in chronic restraint stress: disturbances of the kynurenine metabolic pathway in both the gut and brain

Yuanyuan Deng et al.

Summary: The research found that long-term stress disrupts Kyn metabolism and endocrine function, accompanied by disrupted homeostasis of certain microbiota, collectively contributing to the development of depression-like behavior.

GUT MICROBES (2021)

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Article Gastroenterology & Hepatology

Effects of stress-related peptides on chloride secretion in the mouse proximal colon

Sumei Liu et al.

Summary: This study revealed sex differences in colonic secretion and responses to stress-related peptides, with CRF2 receptors playing a more prominent role in colonic secretion in male mice. The greater baseline secretion and responses to UCNs in males may contribute to the higher prevalence of diarrhea-predominant IBS.

NEUROGASTROENTEROLOGY AND MOTILITY (2021)

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Article Biochemistry & Molecular Biology

Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome

Marcus Boehme et al.

MOLECULAR PSYCHIATRY (2020)

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Review Psychology

Depression's Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome

Joana S. Cruz-Pereira et al.

ANNUAL REVIEW OF PSYCHOLOGY, VOL 71 (2020)

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Article Immunology

The role of the microbiota in acute stress-induced myeloid immune cell trafficking

Marcel van de Wouw et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

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Article Anesthesiology

Blockade of BDNF signalling attenuates chronic visceral hypersensitivity in an IBS-like rat model

Fei Fan et al.

EUROPEAN JOURNAL OF PAIN (2020)

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Article Neurosciences

Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease

Hemraj B. Dodiya et al.

NEUROBIOLOGY OF DISEASE (2020)

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Article Neurosciences

Protease-dependent excitation of nodose ganglion neurons by commensal gut bacteria

Sabindra Pradhananga et al.

JOURNAL OF PHYSIOLOGY-LONDON (2020)

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Article Endocrinology & Metabolism

Fecal microbiota and metabolites are distinct in a pilot study of pediatric Crohn's disease patients with higher levels of perceived stress

Laura M. Mackner et al.

PSYCHONEUROENDOCRINOLOGY (2020)

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Article Medicine, General & Internal

Gastrointestinal pain

Asbjorn M. Drewes et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

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Article Multidisciplinary Sciences

Psychologic stress and disease activity in patients with inflammatory bowel disease: A multicenter cross-sectional study

Manabu Araki et al.

PLOS ONE (2020)

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Article Gastroenterology & Hepatology

Acute stress induces visceral hypersensitivity via glucocorticoid receptor-mediated membrane insertion of TRPM8: Involvement of a non-receptor tyrosine kinase Pyk2

Qing-Qing Luo et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2020)

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Article Gastroenterology & Hepatology

Gut-brain axis serotonergic responses to acute stress exposure are microbiome-dependent

Joshua M. Lyte et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2020)

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Article Gastroenterology & Hepatology

Proton pump inhibitors enhance intestinal permeability via dysbiosis of gut microbiota under stressed conditions in mice

Shingo Takashima et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2020)

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Article Microbiology

Influence of Catecholamines (Epinephrine/Norepinephrine) on Biofilm Formation and Adhesion in Pathogenic and Probiotic Strains ofEnterococcus faecalis

Melyssa Cambronel et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Article Medicine, Research & Experimental

The Release of Norepinephrine in C57BL/6J Mice Treated with 6-Hydroxydopamine (6-OHDA) is Associated with Translocations in Enteric Escherichia coli via the QseC Histidine Kinase Receptor

Jun Meng et al.

MEDICAL SCIENCE MONITOR (2020)

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Article Clinical Neurology

Betaine supplementation is associated with the resilience in mice after chronic social defeat stress: a role of brain-gut-microbiota axis

Youge Qu et al.

JOURNAL OF AFFECTIVE DISORDERS (2020)

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Article Clinical Neurology

Effects of microbiota transplantation and the role of the vagus nerve in gut-brain axis in animals subjected to chronic mild stress

Pricila Romao Marcondes Avila et al.

JOURNAL OF AFFECTIVE DISORDERS (2020)

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Article Gastroenterology & Hepatology

Glycated milk protein fermented withLactobacillus rhamnosusameliorates the cognitive health of mice under mild-stress condition

Nam Su Oh et al.

GUT MICROBES (2020)

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Article Neurosciences

Towards a psychobiotic therapy for depression: Bifidobacterium breve CCFM1025 reverses chronic stress-induced depressive symptoms and gut microbial abnormalities in mice

Peijun Tian et al.

NEUROBIOLOGY OF STRESS (2020)

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Article Biochemistry & Molecular Biology

Stress-induced intestinal barrier dysfunction is exacerbated during diet-induced obesity

Wafa Bahlouli et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2020)

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Article Physiology

Increased vascular α1-adrenergic receptor sensitivity in older adults with posttraumatic stress disorder

Cortnie L. Hartwig et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2020)

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Article Neurosciences

Colon-delivered short-chain fatty acids attenuate the cortisol response to psychosocial stress in healthy men: a randomized, placebo-controlled trial

Boushra Dalile et al.

NEUROPSYCHOPHARMACOLOGY (2020)

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Article Multidisciplinary Sciences

Epidemiology and associated microbiota changes in deployed military personnel at high risk of traveler's diarrhea

William A. Walters et al.

PLOS ONE (2020)

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Review Surgery

The efficacy and safety of probiotics for patients with constipation-predominant irritable bowel syndrome: A systematic review and meta-analysis based on seventeen randomized controlled trials

Yong Wen et al.

INTERNATIONAL JOURNAL OF SURGERY (2020)

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Impact of a Model Used to Simulate Chronic Socio-Environmental Stressors Encountered during Spaceflight on Murine Intestinal Microbiota

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Functional gastrointestinal disorders: advances in understanding and management

Christopher J. Black et al.

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Honey protects against chronic unpredictable mild stress induced- intestinal barrier disintegration and hepatic inflammation

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The gut microbiota metabolite indole increases emotional responses and adrenal medulla activity in chronically stressed male mice

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Deciphering functional redundancy in the human microbiome

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A Potential Role for Stress-Induced Microbial Alterations in IgA-Associated Irritable Bowel Syndrome with Diarrhea

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Crocin-I alleviates the depression-like behaviors probably via modulating microbiota-gut-brain axis in mice exposed to chronic restraint stress

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Gutted! Unraveling the Role of the Microbiome in Major Depressive Disorder

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Sex-based differences in inflammatory bowel diseases: a review

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Prenatal stress disrupts social behavior, cortical neurobiology and commensal microbes in adult male offspring

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Increased Burden of Psychiatric Disorders in Inflammatory Bowel Disease

Charles N. Bernstein et al.

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Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats

Tsukasa Nozu et al.

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Effect of Antidepressants and Psychological Therapies in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-Analysis

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Insight into Pain Modulation: Nociceptors Sensitization and Therapeutic Targets

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Metformin prevents colonic barrier dysfunction by inhibiting mast cell activation in maternal separation-induced IBS-like rats

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β1-adrenergic receptors mediate plasma acyl-ghrelin elevation and depressive-like behavior induced by chronic psychosocial stress

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Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation

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Effects of regulating gut microbiota on the serotonin metabolism in the chronic unpredictable mild stress rat model

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Prophylactic Effects of Bifidobacterium adolescentis on Anxiety and Depression-Like Phenotypes After Chronic Stress: A Role of the Gut Microbiota-Inflammation Axis

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Dietary Oligosaccharides Attenuate Stress-Induced Disruptions in Immune Reactivity and Microbial B-Vitamin Metabolism

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The role of peripheral corticotropin-releasing factor signaling in a rat model of stress-induced gastric hyperalgesia

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British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults

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Abnormal composition of gut microbiota is associated with resilience versus susceptibility to inescapable electric stress

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Chronic Unpredictable Mild Stress in Rats Induces Colonic Inflammation

Lina Wei et al.

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The Gut Microbiome Modulates the Changes in Liver Metabolism and in Inflammatory Processes in the Brain of Chronic Unpredictable Mild Stress Rats

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Grape Seed Extract Eliminates Visceral Allodynia and Colonic Hyperpermeability Induced by Repeated Water Avoidance Stress in Rats

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Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis

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Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice

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Stress matters: Randomized controlled trial on the effect of probiotics on neurocognition

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Resilience is decreased in irritable bowel syndrome and associated with symptoms and cortisol response

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VIP is involved in peripheral CRF-induced stimulation of propulsive colonic motor function and diarrhea in male rats

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Lovastatin inhibits visceral allodynia and increased colonic permeability induced by lipopolysaccharide or repeated water avoidance stress in rats

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The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus

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Shuganyin decoction improves the intestinal barrier function in a rat model of irritable bowel syndrome induced by water-avoidance stress

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Brain and Gut CRF Signaling: Biological Actions and Role in the Gastrointestinal Tract

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Altered colonic sensory and barrier functions by CRF: roles of TLR4 and IL-1

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Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations

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Immobilization stress- induced Escherichia coli causes anxiety by inducing NF-κB activation through gut microbiota disturbance

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P2X3 receptor-mediated visceral hyperalgesia and neuronal sensitization following exposure to PTSD-like stress in the dorsal root ganglia of rats

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Antinociception induced by a novel α2A adrenergic receptor agonist in rodents acute and chronic pain models

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Evidence of Bidirectional Associations Between Perceived Stress and Symptom Activity: A Prospective Longitudinal Investigation in Inflammatory Bowel Disease

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Repeated water avoidance stress induces visceral hypersensitivity: Role of interleukin-1, interleukin-6, and peripheral corticotropin-releasing factor

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Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity

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Glucocorticoids and gut bacteria: The GALF Hypothesis in the metagenomic era

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Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner

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Stress induces more serious barrier dysfunction in follicle-associated epithelium than villus epithelium involving mast cells and protease-activated receptor-2

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Chronic Early-life Stress in Rat Pups Alters Basal Corticosterone, Intestinal Permeability, and Fecal Microbiota at Weaning: Influence of Sex

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Chronic social stress in pigs impairs intestinal barrier and nutrient transporter function, and alters neuro-immune mediator and receptor expression

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The Norepinephrine Metabolite 3,4-Dihydroxymandelic Acid Is Produced by the Commensal Microbiota and Promotes Chemotaxis and Virulence Gene Expression in Enterohemorrhagic Escherichia coli

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Introduction to the human gut microbiota

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Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress

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Social stress-enhanced severity of Citrobacter rodentium-induced colitis is CCL2-dependent and attenuated by probiotic Lactobacillus reuteri

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Endogenous CRF in rat large intestine mediates motor and secretory responses to stress

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Microbiota Diumal Rhythmicity Programs Host Transcriptome Oscillations

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Peripheral and central alterations affecting spinal nociceptive processing and pain at adulthood in rats exposed to neonatal maternal deprivation

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Stress increases descending inhibition in mouse and human colon

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Subacute stress and chronic stress interact to decrease intestinal barrier function in rats

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STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS (2016)

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Limited Nesting Stress Alters Maternal Behavior and In Vivo Intestinal Permeability in Male Wistar Pup Rats

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Microbial Endocrinology in the Pathogenesis of Infectious Disease

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Epigenetic Regulation of Genes That Modulate Chronic Stress-Induced Visceral Pain in the Peripheral Nervous System

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Intermittent fasting modulates IgA levels in the small intestine under intense stress: A mouse model

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Neonatal stress from limited bedding elicits visceral hyperalgesia in adult rats

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Maternal prenatal stress is associated with the infant intestinal microbiota

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Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood

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Effect of Antidepressants and Psychological Therapies, Including Hypnotherapy, in Irritable Bowel Syndrome: Systematic Review and Meta-Analysis

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Stress disrupts intestinal mucus barrier in rats via mucin O-glycosylation shift: prevention by a probiotic treatment

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A Balance Theory of Peripheral Corticotropin-Releasing Factor Receptor Type 1 and Type 2 Signaling to Induce Colonic Contractions and Visceral Hyperalgesia in Rats

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Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism

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Modulation of enteric neurons by interleukin-6 and corticotropin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome

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Chronic stress mediators act synergistically on colonic nociceptive mouse dorsal root ganglia neurons to increase excitability

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Influence of a new 5-HT4 receptor partial agonist, YKP10811, on visceral hypersensitivity in rats triggered by stress and inflammation

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Early maternal separation induces alterations of colonic epithelial permeability and morphology

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Interleukin-6 Modulation of Intestinal Epithelial Tight Junction Permeability Is Mediated by JNK Pathway Activation of Claudin-2 Gene

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Adrenergic β2-Receptors Mediates Visceral Hypersensitivity Induced by Heterotypic Intermittent Stress in Rats

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Multispecies probiotic protects gut barrier function in experimental models

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Crosstalk between interleukin-6 and corticotropin-releasing factor modulate submucosal plexus activity and colonic secretion

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Early Life Stress Triggers Persistent Colonic Barrier Dysfunction and Exacerbates Colitis in Adult IL-10-/- Mice

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Influence of simethicone and alverine on stress-induced alterations of colonic permeability and sensitivity in rats: beneficial effect of their association

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PKCγ receptor mediates visceral nociception and hyperalgesia following exposure to PTSD-like stress in the spinal cord of rats

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The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

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Corticosterone mediates stress-related increased intestinal permeability in a region-specific manner

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Vasoactive intestinal polypeptide regulates barrier function via mast cells in human intestinal follicle-associated epithelium and during stress in rats

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Stress-Derived Corticotropin Releasing Factor Breaches Epithelial Endotoxin Tolerance

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Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress

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Stress modulates intestinal secretory immunoglobulin A

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Nerve growth factor-mediated neuronal plasticity in spinal cord contributes to neonatal maternal separation-induced visceral hypersensitivity in rats

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The brain-gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study

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Enterohemorrhagic Escherichia coli Virulence Regulation by Two Bacterial Adrenergic Kinases, QseC and QseE

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A marketed fermented dairy product containing Bifidobacterium lactis CNCM I-2494 suppresses gut hypersensitivity and colonic barrier disruption induced by acute stress in rats

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Effects of Gut Microbes on Nutrient Absorption and Energy Regulation

Rosa Krajmalnik-Brown et al.

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CRF Induces Intestinal Epithelial Barrier Injury via the Release of Mast Cell Proteases and TNF-α

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Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Chronic psychosocial stress induces reversible mitochondrial damage and corticotropin-releasing factor receptor type-1 upregulation in the rat intestine and IBS-like gut dysfunction

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Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats

Afifa Ait-Belgnaoui et al.

PSYCHONEUROENDOCRINOLOGY (2012)

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Article Pharmacology & Pharmacy

A protease inhibitor against acute stress-induced visceral hypersensitivity and paracellular permeability in rats

Juhui Zhao et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2011)

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Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Javier A. Bravo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Gastroenterology & Hepatology

A Prospective Population-Based Study of Triggers of Symptomatic Flares in IBD

Charles N. Bernstein et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2010)

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Article Gastroenterology & Hepatology

Early weaning stress impairs development of mucosal barrier function in the porcine intestine

Feli Smith et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)

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Article Immunology

Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress

Maria Vicario et al.

BRAIN BEHAVIOR AND IMMUNITY (2010)

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Article Biochemistry & Molecular Biology

Transient Receptor Potential Vanilloid-1 (TRPV1) and Ankyrin-1 (TRPA1) Participate in Visceral Hyperalgesia in Chronic Water Avoidance Stress Rat Model

Yan-Bo Yu et al.

NEUROCHEMICAL RESEARCH (2010)

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Review Gastroenterology & Hepatology

The participation of the sympathetic innervation of the gastrointestinal tract in disease states

A. E. Lomax et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2010)

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Article Clinical Neurology

Stress-induced barrier disruption of rat follicle-associated epithelium involves corticotropin-releasing hormone, acetylcholine, substance P, and mast cells

å. v. Keita et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2010)

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Review Physiology

Gut Microbiota in Health and Disease

Inna Sekirov et al.

PHYSIOLOGICAL REVIEWS (2010)

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Article Gastroenterology & Hepatology

Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome

N. M. Thoua et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2009)

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Article Gastroenterology & Hepatology

Cortagine, a CRF1 agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathways

Muriel Larauche et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2009)

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Article Biochemistry & Molecular Biology

Role of CRF Receptor Signaling in Stress Vulnerability, Anxiety, and Depression

Richard L. Hauger et al.

GLUCOCORTICOIDS AND MOOD CLINICAL MANIFESTATIONS, RISK FACTORS, AND MOLECULAR MECHANISMS (2009)

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Article Neurosciences

Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses

Siobhain M. O'Mahony et al.

BIOLOGICAL PSYCHIATRY (2009)

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Article Gastroenterology & Hepatology

Childhood Trauma Is Associated With Hypothalamic-Pituitary-Adrenal Axis Responsiveness in Irritable Bowel Syndrome

Elizabeth J. Videlock et al.

GASTROENTEROLOGY (2009)

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Article Medicine, Research & Experimental

Acute stress increases colonic paracellular permeability in mice through a mast cell-independent mechanism: Involvement of pancreatic trypsin

Julien Demaude et al.

LIFE SCIENCES (2009)

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Review Gastroenterology & Hepatology

Brain imaging approaches to the study of functional GI disorders: A Rome Working Team Report

E. A. Mayer et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2009)

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Article Multidisciplinary Sciences

The two-component system QseEF and the membrane protein QseG link adrenergic and stress sensing to bacterial pathogenesis

Nicola C. Reading et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Immunology

Maternal stress during late gestation has moderate but long-lasting effects on the immune system of the piglets

David Couret et al.

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2009)

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The QseC Adrenergic Signaling Cascade in Enterohemorrhagic E. coli (EHEC)

David T. Hughes et al.

PLOS PATHOGENS (2009)

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Article Gastroenterology & Hepatology

Chronic peripheral administration of corticotropin-releasing factor causes colonic barrier dysfunction similar to psychological stress

Aaron A. Teitelbaum et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)

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Article Gastroenterology & Hepatology

Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats

Muriel Larauche et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)

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Article Psychology, Biological

Investigating the role of perceived stress on bacterial flora activity and salivary cortisol secretion: A possible mechanism underlying susceptibility to illness

Simon R. Knowles et al.

BIOLOGICAL PSYCHOLOGY (2008)

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Article Gastroenterology & Hepatology

Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation

Carmen Alonso et al.

GASTROENTEROLOGY (2008)

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Article Gastroenterology & Hepatology

Corticotropin-releasing hormone receptor 1 antagonist blocks colonic hypersensitivity induced by a combination of inflammation and repetitive colorectal distension

K. Saito-Nakaya et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2008)

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Article Gastroenterology & Hepatology

Influence of experimentally induced anxiety on rectal sensorimotor function in healthy humans

B. Geeraerts et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2008)

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Article Endocrinology & Metabolism

Understanding the potency of stressful early life experiences on brain and body function

Bruce S. McEwen

METABOLISM-CLINICAL AND EXPERIMENTAL (2008)

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Stress neuropeptides evoke epithelial responses via mast cell activation in the rat colon

Javier Santos et al.

PSYCHONEUROENDOCRINOLOGY (2008)

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Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro

C. Wallon et al.

GUT (2008)

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Article Gastroenterology & Hepatology

Peripheral corticotropin releasing factor (CRF) and a novel CRF1 receptor agonist, stressin1-A activate CRF1 receptor expressing cholinergic and nitrergic myenteric neurons selectively in the colon of conscious rats

P. -Q. Yuan et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2007)

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Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation

Melanie G. Gareau et al.

GUT (2007)

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Differential effects of epinephrine, norepinephrine, and indole on Escherichia coli O157:H7 chemotaxis, colonization, and gene expression

Tarun Bansal et al.

INFECTION AND IMMUNITY (2007)

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Article Gastroenterology & Hepatology

Corticotropin-releasing factor receptor 1-deficient mice show decreased anxiety and colonic sensitivity

N. Trimble et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2007)

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Dexamethasone prevents visceral hyperalgesia but not colonic permeability increase induced by luminal protease-activated receptor-2 agonist in rats

Richard Roka et al.

GUT (2007)

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Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs

Adam J. Moeser et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)

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Article Gastroenterology & Hepatology

Neonatal maternal separation of rat pups results in abnormal cholinergic regulation of epithelial permeability

Melanie G. Gareau et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)

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Article Gastroenterology & Hepatology

Chronic psychological stress alters epithelial cell turn-over in rat ileum

Gaelle Boudry et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)

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Article Physiology

Psychological stress impairs Na+-dependent glucose absorption and increases GLUT2 expression in the rat jejunal brush-border membrane

Gaelle Boudry et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2007)

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Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress

M. Zareie et al.

GUT (2006)

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Stress-induced, breakdown of intestinal barrier function in the rat: Reversal by wood creosote

Tomoo Kuge et al.

LIFE SCIENCES (2006)

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Phenotypic changes in colonocytes following acute stress or activation of mast cells in mice: implications for delayed epithelial barrier dysfunction

J Demaude et al.

GUT (2006)

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Fetal programming of hypothalamo-pituitary-adrenal function: prenatal stress and glucocorticoids

A Kapoor et al.

JOURNAL OF PHYSIOLOGY-LONDON (2006)

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Chronic psychological stress in rats induces intestinal sensitization to luminal antigens

PC Yang et al.

AMERICAN JOURNAL OF PATHOLOGY (2006)

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Neonatal maternal separation causes colonic dysfunction in rat pups including impaired host resistance

MG Gareau et al.

PEDIATRIC RESEARCH (2006)

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Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia

S Bradesi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)

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Article Gastroenterology & Hepatology

Corticotropin-releasing factor 1 receptor-mediated mechanisms inhibit colonic hypersensitivity in rats

B Greenwood-van Meerveld et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2005)

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Stress and the brain:: From adaptation to disease

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NATURE REVIEWS NEUROSCIENCE (2005)

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An acute stressor enhances sensitivity to a chemical irritant and increases (51)CrEDTA permeability of the colon in adult rats

AM Milde et al.

INTEGRATIVE PHYSIOLOGICAL AND BEHAVIORAL SCIENCE (2005)

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Acute stress-induced hypersensitivity to colonic distension depends upon increase in paracellular permeability: role of myosin light chain kinase

A Ait-Belgnaoui et al.

PAIN (2005)

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Increased antigen and bacterial uptake in follicle associated epithelium induced by chronic psychological stress in rats

ÅK Velin et al.

GUT (2004)

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Neonatal maternal deprivation triggers long term alterations in colonic epithelial barrier and mucosal immunity in rats

F Barreau et al.

GUT (2004)

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Nerve growth factor mediates alterations of colonic sensitivity and mucosal barrier induced by neonatal stress in rats

F Barreau et al.

GASTROENTEROLOGY (2004)

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Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice

N Sudo et al.

JOURNAL OF PHYSIOLOGY-LONDON (2004)

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Effect of acute physical and psychological stress on gut autonomic innervation in irritable bowel syndrome

CDR Murray et al.

GASTROENTEROLOGY (2004)

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A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats

M Million et al.

BRAIN RESEARCH (2003)

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Stress-induced disruption of colonic epithelial barrier:: Role of interferon-γ and myosin light chain kinase in mice

L Ferrier et al.

GASTROENTEROLOGY (2003)

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Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress

JD Söderholm et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)

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Growth stimulation of intestinal commensal Escherichia coli by catecholamines:: A possible contributory factor in trauma-induced sepsis

PP Freestone et al.

SHOCK (2002)

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Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine

JD Söderholm et al.

GASTROENTEROLOGY (2002)

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α2-adrenoceptors in the enteric nervous system:: a study in α2A-adrenoceptor-deficient mice

J Scheibner et al.

BRITISH JOURNAL OF PHARMACOLOGY (2002)

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Role Of α2-adrenoceptors in the sympathetic inhibition of motility reflexes of guinea-pig ileum

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JOURNAL OF PHYSIOLOGY-LONDON (2001)

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Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat

J Santos et al.

GUT (2001)

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Article Gastroenterology & Hepatology

Stress and the gastrointestinal tract II. Stress and intestinal barrier function

JD Soderholm et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2001)

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Induction of vanilloid receptor channel activity by protein kinase C

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NATURE (2000)

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The neurobiology of stress and gastrointestinal disease

EA Mayer

GUT (2000)

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Regulation of α2A-adrenoceptor expression by chronic stress in neurons of the brain stem

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BRAIN RESEARCH (2000)

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