☆ 4.6 Review

Unravelling vagal hypersensitivity in chronic cough: A distinct disease

JOURNAL OF PHYSIOLOGY-LONDON (2023)

Related references

Note: Only part of the references are listed.

Article Pharmacology & Pharmacy

Preclinical and Clinical Pharmacokinetics and Bioavailability in Healthy Volunteers of a Novel Formulation of the Selective P2X3 Receptor Antagonist Eliapixant

Klaus Francke et al.

Summary: This study evaluated several novel eliapixant formulations through in vitro and animal experiments, and identified a potential formulation to improve bioavailability. In a phase I clinical trial, the new formulation demonstrated higher bioavailability compared to immediate-release eliapixant and can be administered with or without food.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS (2023)

Add to Collection

Article Respiratory System

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 2b Trial of P2X3 Receptor Antagonist Sivopixant for Refractory or Unexplained Chronic Cough

Lorcan McGarvey et al.

Summary: The goal of this study was to determine the optimal dose of sivopixant for refractory or unexplained chronic cough. The results showed that the 300 mg dose had the greatest improvements in cough frequency and patient-reported outcomes, with mild to moderate reversible taste disturbance.

LUNG (2023)

Add to Collection

Article Critical Care Medicine

Chronic Cough-Related Differences in Brain Morphometry in Adults A Population-Based Study

Johnmary T. Arinze et al.

Summary: Individuals with chronic cough have a smaller volume of the anterior cingulate cortex, which is a brain region involved in cough suppression. This study suggests that the morphometric changes in the brain structure of chronic cough patients may result in maladaptive responses to cough stimuli.

CHEST (2023)

Add to Collection

Review Pharmacology & Pharmacy

Emerging drugs in the treatment of chronic cough

Danica Brister et al.

Summary: Chronic cough is a challenging condition to manage, even after ruling out underlying respiratory, nasal, or upper gastrointestinal diseases. This review discusses existing treatments and the current research landscape for the development of new therapies for refractory or unexplained chronic cough.

EXPERT OPINION ON EMERGING DRUGS (2023)

Add to Collection

Review Oncology

From bench to bedside: The role of cough hypersensitivity in chronic cough

Matthew G. Drake et al.

Summary: Chronic cough is a burdensome condition that significantly affects quality of life and lacks effective therapies. Recent studies have focused on targeting ion channels and receptors involved in cough activation and processing, providing new insights and treatment options for chronic cough.

CLINICAL AND TRANSLATIONAL MEDICINE (2023)

Add to Collection

Article Respiratory System

The P2X3 receptor antagonist filapixant in patients with refractory chronic cough: a randomized controlled trial

Christian Friedrich et al.

Summary: This study investigated the efficacy, safety, and tolerability of the P2X3 receptor antagonist filapixant in patients with refractory chronic cough. The results showed that filapixant significantly reduced cough frequency and severity, improved cough health-related quality of life, and was well tolerated with only minor taste-related adverse events.

RESPIRATORY RESEARCH (2023)

Add to Collection

Article Respiratory System

Antitussive efficacy of the current treatment protocol for refractory chronic cough: our real-world experience in a retrospective cohort study

Mengru Zhang et al.

Summary: This study summarized the outcomes of the current treatments for refractory chronic cough (RCC) and found that trying different neuromodulators is a pragmatic strategy that helps around two-thirds of patients with RCC. Relapse is common on withdrawal or reduction of dosage, indicating an urgent need for novel medication for RCC.

THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE (2023)

Add to Collection

Article Critical Care Medicine

Structural and Functional Correlates of Higher Cortical Brain Regions in Chronic Refractory Cough

Eun Namgung et al.

Summary: The study found that patients with chronic refractory cough exhibited structural and functional alterations in the left frontal brain regions, which were associated with cough duration, severity, and psychological/social impact.

CHEST (2022)

Add to Collection

Article Medicine, General & Internal

Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials

Lorcan P McGarvey et al.

LANCET (2022)

Add to Collection

Editorial Material Critical Care Medicine

Chronic cough and cough hypersensitivity: from mechanistic insights to novel antitussives

Stuart B. Mazzone et al.

LANCET RESPIRATORY MEDICINE (2022)

Add to Collection

Article Medicine, General & Internal

Cough hypersensitivity and chronic cough

Kian Fan Chung et al.

Summary: Chronic cough is a prevalent and challenging condition with various underlying causes. It is associated with cough hypersensitivity, characterized by excessive coughing in response to stimuli, resulting in significant impact on patients' quality of life. Advances in understanding the mechanisms of cough hypersensitivity have led to the development of new therapies for chronic cough in adults. Personalized treatment approaches and phenotyping cough patients may hold promise for future management.

NATURE REVIEWS DISEASE PRIMERS (2022)

Add to Collection

Review Pharmacology & Pharmacy

Treatment of chronic cough: P2X3 receptor antagonists and beyond

Dominic L. Sykes et al.

Summary: Chronic cough has been a significant burden for patients, with no approved pharmacological therapies available. However, recent research on the pathophysiological mechanisms of chronic cough has provided new hope, including the potential use of P2X3 receptor antagonists and other emerging peripheral acting pharmacological agents.

PHARMACOLOGY & THERAPEUTICS (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Investigating the diagnostic utility of high-resolution oesophageal manometry in patients with refractory respiratory symptoms

Dominic L. Sykes et al.

Summary: This study investigated patterns of esophageal motility in patients with refractory respiratory symptoms using high-resolution esophageal manometry (HROM). The findings revealed that two-thirds of the patients had esophageal dysmotility, suggesting a potential contribution of motility disorders to the development and progression of respiratory diseases.

RESPIRATORY MEDICINE (2022)

Add to Collection

Article Critical Care Medicine

Aprepitant for Cough in Lung Cancer A Randomized Placebo-controlled Trial and Mechanistic Insights

Jaclyn A. Smith et al.

Summary: The study aimed to evaluate aprepitant in the treatment of cough in patients with lung cancer and investigate its mechanism on the vagal nerve tissue. The results showed that aprepitant significantly reduced cough frequency in lung cancer patients and improved patient-reported outcomes. Experimental findings indicated that aprepitant achieved its antitussive effect by inhibiting substance P-induced depolarization of the vagus nerve.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Add to Collection

Article Respiratory System

Modified Reflux Scintigraphy Detects Pulmonary Microaspiration in Severe Gastro-Esophageal and Laryngopharyngeal Reflux Disease

Jin-soo Park et al.

Summary: The study revealed frequent early scintigraphic reflux in the pharynx and proximal esophagus in severe reflux patients. A high rate of reflux-related pulmonary aspiration was also observed.

LUNG (2021)

Add to Collection

Article Respiratory System

Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough

Valerie J. Ludbrook et al.

Summary: An adaptive study was conducted to determine the effectiveness of using the selective TRPV4 channel blocker GSK2798745 in reducing cough in refractory chronic cough patients. Interim analysis showed that there was a 32% increase in cough counts for GSK2798745 compared to placebo on Day 7, leading to the study being stopped due to lack of efficacy. Overall, there was no evidence of an anti-tussive effect of GSK2798745 in the study.

ERJ OPEN RESEARCH (2021)

Add to Collection

Article Respiratory System

Is laryngeal hypersensitivity the basis of unexplained or refractory chronic cough?

Krishna M. Sundar et al.

Summary: The study found that cough hypersensitivity and laryngeal dysfunction are common in patients with refractory chronic cough and unexplained chronic cough. Cough hypersensitivity can lead to symptoms such as allotussia and hypertussia in patients; meanwhile, laryngeal functional abnormalities also have a high prevalence in these patients.

ERJ OPEN RESEARCH (2021)

Add to Collection

Article Respiratory System

The Japanese respiratory society guidelines for the management of cough and sputum (digest edition)

Hiroshi Mukae et al.

Summary: The article provides a general overview of cough and sputum complaints in outpatient visits, discussing the management of acute and chronic cough. It outlines different causes of cough and sputum, emphasizing the importance of thorough investigation for chronic cough.

RESPIRATORY INVESTIGATION (2021)

Add to Collection

Article Critical Care Medicine

The Neurokinin-1 Receptor Antagonist Orvepitant Is a Novel Antitussive Therapy for Chronic Refractory Cough Results From a Phase 2 Pilot Study (VOLCANO-1)

Jaclyn Smith et al.

CHEST (2020)

Add to Collection

Article Pharmacology & Pharmacy

Association Between Proton Pump Inhibitors and Asthma: A Population-Based Cohort Study

Yao-Tung Wang et al.

FRONTIERS IN PHARMACOLOGY (2020)

Add to Collection

Review Medicine, General & Internal

Management of chronic refractory cough in adults

Dina Visca et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2020)

Add to Collection

Article Pharmacology & Pharmacy

Prediction of therapeutic efficacy of gabapentin by Hull Airway Reflux Questionnaire in chronic refractory cough

Mengru Zhang et al.

THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2020)

Add to Collection

Article Respiratory System

The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: a randomised placebo-controlled study

Alyn H. Morice et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Add to Collection

Article Pharmacology & Pharmacy

Heterogeneity of cough neurobiology: Clinical implications

Stuart B. Mazzone et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2019)

Add to Collection

Article Pharmacology & Pharmacy

Are neural pathways processing airway inputs sensitized in patients with cough hypersensitivity?

Michael J. Farrell et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2019)

Add to Collection

Review Chemistry, Medicinal

Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications

Gabriella Marucci et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2019)

Add to Collection

Article Allergy

Cough-Related Laryngeal Sensations and Triggers in Adults With Chronic Cough: Symptom Profile and Impact

Ha-Kyeong Won et al.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2019)

Add to Collection

Article Critical Care Medicine

Classification of Cough as a Symptom in Adults and Management Algorithms CHEST Guideline and Expert Panel Report

Richard S. Irwin et al.

CHEST (2018)

Add to Collection

Article Critical Care Medicine

Prevalence of Arnold Nerve Reflex in Adults and Children With Chronic Cough

Peter V. Dicpinigaitis et al.

CHEST (2018)

Add to Collection

Editorial Material Respiratory System

Clinical Practice Guidelines for Diagnosis and Management of Cough-Chinese Thoracic Society (CTS) Asthma Consortium

Kefang Lai et al.

JOURNAL OF THORACIC DISEASE (2018)

Add to Collection

Article Respiratory System

Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity?

Helen Elizabeth Fowles et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

Add to Collection

Article Pharmacology & Pharmacy

TRPA1 receptors in chronic cough

Alyn H. Morice

PULMONARY PHARMACOLOGY & THERAPEUTICS (2017)

Add to Collection

Article Critical Care Medicine

XEN-D0501, a Novel Transient Receptor Potential Vanilloid 1 Antagonist, Does Not Reduce Cough in Patients with Refractory Cough

Maria G. Belvisi et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

Add to Collection

Article Critical Care Medicine

Treatment of Unexplained Chronic Cough CHEST Guideline and Expert Panel Report

Peter Gibson et al.

CHEST (2016)

Add to Collection

Article Respiratory System

Neural correlates of cough hypersensitivity in humans: evidence for central sensitisation and dysfunctional inhibitory control

Ayaka Ando et al.

THORAX (2016)

Add to Collection

Letter Respiratory System

The global epidemiology of chronic cough in adults: a systematic review and meta-analysis

Woo-Jung Song et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

Add to Collection

Article Respiratory System

The Impact of Chronic Cough: A Cross-Sectional European Survey

Sarah A. F. Chamberlain et al.

LUNG (2015)

Add to Collection

Article Respiratory System

A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response

Alyn H. Morice et al.

EUROPEAN RESPIRATORY JOURNAL (2014)

Add to Collection

Article Respiratory System

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

Alyn H. Morice et al.

EUROPEAN RESPIRATORY JOURNAL (2014)

Add to Collection

Article Allergy

Capsaicin Cough Sensitivity is Related to the Older Female Predominant Feature in Chronic Cough Patients

Woo-Jung Song et al.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2014)

Add to Collection

Article Critical Care Medicine

Brain Activity Associated with Placebo Suppression of the Urge-to-Cough in Humans

Jennifer Leech et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

Add to Collection

Article Medicine, General & Internal

Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial

Nicole M. Ryan et al.

LANCET (2012)

Add to Collection

Article Neurosciences

Investigation of the Neural Control of Cough and Cough Suppression in Humans Using Functional Brain Imaging

Stuart B. Mazzone et al.

JOURNAL OF NEUROSCIENCE (2011)

Add to Collection

Article Respiratory System

Cough Hypersensitivity Syndrome: A Distinct Clinical Entity

A. H. Morice et al.

LUNG (2011)

Add to Collection

Article Respiratory System

Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study

Shoaib Faruqi et al.

RESPIROLOGY (2011)

Add to Collection

Article Pharmacology & Pharmacy

Mapping supramedullary pathways involved in cough using functional brain imaging: Comparison with pain

Stuart B. Mazzone et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2009)

Add to Collection

Article Critical Care Medicine

Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging

Stuart B. Mazzone et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)

Add to Collection

Article Critical Care Medicine

Opiate therapy in chronic cough

Alyn H. Morice et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)

Add to Collection

© Peeref 2019-2024. All rights reserved.