Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 47-48, Issue -, Pages 15-23Publisher
ELSEVIER
DOI: 10.1016/j.mam.2015.09.004
Keywords
Hematopoietic stem cells; Embryonic stem cells; Induced pluripotent stem cells; Glioma stem cells; Leukemia stem cells; Breast cancer stem cells
Funding
- American Cancer Society [RP-12-090-01-COUN]
- Armstrong Family Foundation
- Department of Defense Breast Cancer Research Program [W81XWH-12-1-0464]
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Stem cells are characterized by the capacity for both self-renewal and generation of all other cell types (pluripotency) or differentiated cells within a particular lineage (multipotency). Stem cells are often localized to hypoxic niches within tissues and hypoxia inducible factors (HIFs) play key roles in the maintenance of pluripotent and multipotent stem cells, as well as cancer stem cells, which are also known as tumor-initiating cells. HIF inhibitors target cancer stem cells and improve the responses to angiogenesis inhibitors and cytotoxic chemotherapy in mouse models of breast cancer. (C) 2015 Elsevier Ltd. All rights reserved.
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