Related references
Note: Only part of the references are listed.
Article
Multidisciplinary Sciences
Avigail Baruch Leshem et al.
Summary: Inspired by the role of intracellular liquid-liquid phase separation (LLPS) in the formation of membraneless organelles, researchers have developed dynamic compartments formed by LLPS of intrinsically disordered proteins (IDPs) or short peptides. However, the molecular mechanisms underlying the formation of biomolecular condensates have not been fully understood. In this study, the authors demonstrate that the LLPS propensity, dynamics, and encapsulation efficiency of designed peptide condensates can be tuned by subtle changes to the peptide composition. This sequence-structure-function correlation could pave the way for the future development of compartments for various applications.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Evan Spruijt
Summary: Liquid-liquid phase separation (LLPS) is essential for the formation of intracellular membraneless compartments and may have played a role in the origins of protocells. While LLPS in simple systems is well understood, there are still many unknowns about LLPS in complex molecular systems. In this article, the author discusses the formation, function, and fate of LLPS condensates in both cell biology and protocell research.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Chemistry, Physical
Simone Pezzotti et al.
Summary: Water actively participates in liquid-liquid phase separation (LLPS) by driving and being involved in the process. LLPS is governed by changes in hydration entropy and enthalpy. To tune LLPS for biological and medical applications, a general model is required to quantify thermodynamic driving forces. In this study, we develop such a model based on measured THz features of hydration populations, revealing the thermodynamic changes and providing a rational means to manipulate LLPS.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Multidisciplinary Sciences
David Zwicker et al.
Summary: Phase separation is an important concept for spatial organization in biological cells, but little is known about the phases formed in systems with many interacting components. Researchers have developed a numerical method based on physical relaxation dynamics to study coexisting phases in such systems. By optimizing interactions between components, similar to how proteins' interactions might have evolved, they found that these evolved interactions robustly lead to a defined number of phases and provide versatile control of phase behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Multidisciplinary Sciences
Guinevere A. Giffin
Summary: The article discusses the correlation between the physicochemical properties of non-standard electrolyte solutions and their ability to enhance energy storage performance of lithium-based batteries, presenting the current research progress and future perspectives.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Xuhui Tong et al.
Summary: Liquid-liquid phase separation (LLPS) is a novel principle that explains the precise regulation of spatial and temporal organization in living cells. It plays a crucial role in various cellular processes and its dysregulation has been linked to cancer development. This review comprehensively summarizes the mechanisms of biomolecular condensate formation and function, and discusses recent advances in understanding the role of aberrant LLPS in cancer pathology. Furthermore, the therapeutic potential of targeting LLPS in cancer research and development of drug candidates is also discussed.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Chemistry, Physical
Ying Chen et al.
Summary: The diffusion behavior of Mg2+ in electrolytes is not as readily accessible as that from Li+ or Na+ when utilizing PFG NMR due to low sensitivity, poor resolution, and rapid relaxation encountered in 25Mg NMR. The high activation enthalpy for exchange (65-70 kJ/mol) can be explained by the structural change of bound DME as evidenced by its reduced C-H bond length, which reveals a relative restriction to Mg2+ diffusion caused by long-range interactions with solvent molecules.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Manzar Abbas et al.
Summary: Liquid-liquid phase separation is crucial in creating cellular compartments and protocells, and the design of short peptide synthons for phase separation is significant. These synthons can concentrate biomolecules and catalyze anabolic reactions, showing potential for new coacervate-based protocells.
Article
Multidisciplinary Sciences
Emiko Zumbro et al.
Summary: Multivalent polymers play a crucial role in biocondensate formation and dynamics, impacting neurodegenerative diseases such as ALS and Alzheimer's. Simulations reveal non-specific binding interactions can lead to significant changes in droplet formation at lower energy levels, and solvent conditions and polymer length also influence phase separation. Further understanding of these interactions could provide insights into disease treatment and experimental systems.
Article
Chemistry, Physical
Ethan P. Kamphaus et al.
Summary: Lithium-sulfur batteries offer significant improvements over traditional lithium-ion batteries but still face challenges such as the polysulfide shuttle effect. Introducing hydrofluorinated ethers into the electrolyte has shown potential in enhancing battery performance and modifying the structure of dissolved polysulfide species.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Review
Cell Biology
Jiahua Lu et al.
Summary: Liquid-liquid phase separation (LLPS) of proteins and nucleic acids is a new paradigm in the study of cellular activities, driving the formation of membrane-less condensates in living cells. The biophysical and biochemical principles underlying LLPS determine the molecular properties and composition of liquid condensates, while their function in cellular activities, especially in a pathological context, remains unclear. Current research is focused on uncovering the roles of LLPS in cancer, including signaling pathways, transcription regulation, and genome stability maintenance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Bin Wang et al.
Summary: LLPS plays a vital role in the formation of membraneless organelles, physiological functions, and disease development. Advances in research methods provide opportunities for deeper understanding of LLPS. It is crucial to stay informed about recent developments in the field to translate current knowledge into therapeutic discoveries.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Electrochemistry
Xia Cao et al.
Summary: Conventional LiPF6/carbonate-based electrolytes have been widely used in graphite-based lithium ion batteries for their stability, but are less stable in Li metal and silicon anodes. Localized high-concentration electrolytes have unique advantages, forming stable SEI layers to improve stability.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Chemistry, Physical
Ying Chen et al.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2020)
Review
Chemistry, Physical
Charles E. Sing et al.
Review
Biochemistry & Molecular Biology
Simon Alberti et al.
Article
Multidisciplinary Sciences
Archishman Ghosh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Review
Chemistry, Physical
Jun-Ho Choi et al.
ANNUAL REVIEW OF PHYSICAL CHEMISTRY, VOL 69
(2018)
Article
Multidisciplinary Sciences
Pepijn G. Moerman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Review
Chemistry, Multidisciplinary
Pieremanuele Canepa et al.
Article
Chemistry, Physical
Michael Salama et al.
JOURNAL OF PHYSICAL CHEMISTRY C
(2016)
Review
Chemistry, Multidisciplinary
Qinglang Ma et al.
Article
Electrochemistry
Ivgeni Shterenberg et al.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2015)
Article
Physics, Multidisciplinary
Clifford P. Brangwynne et al.
Article
Nanoscience & Nanotechnology
Se-Young Ha et al.
ACS APPLIED MATERIALS & INTERFACES
(2014)
Review
Cell Biology
Anthony A. Hyman et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30
(2014)
Article
Chemistry, Multidisciplinary
J Bowers et al.
Review
Chemistry, Multidisciplinary
C Dedonder-Lardeux et al.
