Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 422, Issue C, Pages 203-210Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2015.12.012
Keywords
Type 2 diabetes; Testis; Apoptosis; Oxidative stress; Nuclear factor erythroid 2-related factor 2
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Funding
- National Science Foundation of China [81300724, 81270293, 81302860]
- Scientific Frontier and Interdisciplinary Project of Jilin University
- National Institutes of Health [1R01 DK091338-01A1]
- Key Project of Science and Technology Research of the Ministry of Education [311015]
- Bethune Program B of the Jilin University [2012202]
- Doctoral Program for New Teachers of the Ministry of Education, China [20120061120087]
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To determine whether repetitive exposure to low-dose radiation (LDR) attenuates type 2 diabetes (T2DM)-induced testicular apoptotic cell death in a T2DM rat model, we examined the effects of LDR exposure on diabetic and age-matched control rats. We found that testicular apoptosis and oxidative stress levels were significantly higher in T2DM rats than in control rats. In addition, glucose metabolism related Akt and GSK-3 beta function was downregulated and Akt negative regulators PTP1B and TRB3 were upregulated in the T2DM group. Superoxide dismutase (SOD) activity and catalase content were also found to be decreased in T2DM rats. These effects were partially prevented or reversed by repetitive LDR exposure. Nrf2 and its downstream genes NQ01, SOD, and catalase were significantly upregulated by repetitive exposure to LDR, suggesting that the reduction of T2DM-induced testicular apoptosis due to repetitive LDR exposure likely involves enhancement of testicular Akt-mediated glucose metabolism and anti-oxidative defense mechanisms. (C) 2015 Published by Elsevier Ireland Ltd.
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