Insight into the photolytic degradation products of Rosuvastatin: Full chiral and structural elucidation and conversion kinetics by a combined chromatographic, spectroscopic and theoretical approach

Article Chemistry, Medicinal

Triptycene derivatives as chiral probes for studying the molecular enantiorecognition on sub-2-mu m particle cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase

Alessia Rosetti et al.

Summary: The study analyzed two chiral triptycene derivatives on a Chiralpak IB-U column packed with sub-2-micron diameter particles, achieving sub-minute enantioseparations under normal-phase conditions. The evaluation of the compounds' structural elements and chromatographic behavior revealed that hydrogen bond formation is essential for enantiomer separation.

CHIRALITY (2021)

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Article Biochemistry & Molecular Biology

Comparison of Coated and Immobilized Chiral Stationary Phases Based on Amylose tris-[(S)-α-Methylbenzylcarbamate] for the HPLC Enantiomer Separation of α-Lipoic Acid and Its Reduced Form

Alessia Rosetti et al.

Summary: This research conducted enantioselective separation of ALA and DHALA by HPLC using two amylose-derived chiral stationary phases, without the need for pre- or on-column derivatization. The study is expected to provide insights into the enantioselective action differences between the enantiomers of DHALA in vivo, filling the current research gap in this area.

MOLECULES (2021)

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Article Chemistry, Applied