Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 436, Issue C, Pages 141-149Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2016.07.022
Keywords
Gsdf; XX sex-reversal; Androgen; Medaka; Inbred HNI-II strain; Oryzias sakaizumii
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Funding
- Ministry of Education, Science, Sports and Culture of Japan [21570065]
- Grants-in-Aid for Scientific Research [21570065] Funding Source: KAKEN
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In the inbred HNI-II strain of Oryzias sakaizumii, Dmy and Gsdf are expressed in XY gonads from Stages 35 and 36, respectively, similarly to the inbred Hd-rR strain of Oryzias latipes. However, Dmrt1 respectively becomes detectable at Stage 36 and 5 days post hatching (dph) in the two strains. In XX HNI-II embryos, 17 alpha-methyltestosterone (MT) induces Gsdf mRNA from Stage 36, accompanied by complete sex-reversal in all treated individuals (MT, 10 ng/mL), while Dmrt1 mRNA was first detectable at 5 dph. In XX d-rR, MT induced Gsdf mRNA expression and sex-reversal in only some of the treated individuals. Together, these results suggest the testis differentiation cascade in XY individuals differs between the HNI-II and Hd-rR strains. In addition, it is suggested that androgen-induced XX sex-reversal proceeds via an androgen-Gsdf-Dnirt1 cascade and that Gsdf plays an important role in sex-reversal in medaka. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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