Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 426, Issue C, Pages 33-42Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2016.02.010
Keywords
Bisphenol A; Rat; Uterus; Uterine glands; ESR1; Wnt
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Funding
- Universidad Nacional del Litoral (CAI + D program CAI + D) [50120110100018 LI]
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) [112 201101 00494]
- Agencia Nacional de Promotion Cientifica y Tecnologica (ANPCyT) [PICT 2011-1491, PICT 2014-2348]
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Here we assessed the effects of perinatal exposure to bisphenol A (BPA) on the uterine response to 17 beta-estradiol (E2) in aged rats. Pregnant rats were orally exposed to 0.5 or 50 mu g BPA/kg/day from gestational day 9 until weaning. On postnatal day (PND) 360, the rats were ovariectomized and treated with E2 for three months. The uterine tissue of BPA50 and BPA0.5 rats showed increased density of glands with squamous metaplasia (GSM) and glands with daughter glands respectively. Wnt7a expression was lower in GSM of BPA50 rats than in controls. The expression of estrogen receptor 1 (ESRI) and its 5'- untranslated exons ESR1-O and ESR1-OT was lower in BPA50 rats. Both doses of BPA modified the expression of coactivator proteins and epigenetic regulatory enzymes. Thus, perinatal BPA-exposed rats showed different glandular abnormalities associated with deregulated expression of E2-target genes. Different mechanisms would be involved depending on the BPA dose administered. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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