Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 436, Issue C, Pages 114-129Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2016.07.017
Keywords
Adipocyte; Chemerin; Adipokine; Adipose remodelling; Inflammation; NFkB
Categories
Funding
- National Sciences and Engineering Research Council of Canada (NSERC) Canada Graduate Scholarship
- Izaak Walton Killam Predoctoral Scholarship
- Canadian Research Chair (Tier II) program
- Canadian Institute of Health Research [53161]
- NSERC
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Obesity is associated with white adipose tissue (WAT) remodelling characterized by changes in cellular composition, size, and adipokine secretion. Levels of the adipokine chemerin are positively associated with obesity; however, the biological function of chemerin in WAT is poorly understood. We identified factors involved in WAT remodelling, including matrix metalloproteinase (Mmp)3 and chemokines (Ccl2, 3, 5, 7), as novel targets of chemerin signalling in mature adipocytes. Inhibition of chemerin signalling increased MMP activity and the recruitment of macrophages towards adipocyte-conditioned media. These effects were mediated through increases in NFkB signalling, suggesting that chemerin exerts an anti-inflammatory influence. We also demonstrate that multiple chemerin isoforms are present in adipocyte-conditioned media and that adipocyte-secreted chemerin, but not synthetic chemerin, recapitulates the activity of endogenous chemerin. Considered altogether, this suggests that endogenously secreted chemerin plays an autocrine/paracrine role in WAT, identifying chemerin as a therapeutic target to modulate adipose remodelling. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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