Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 88, Issue 19, Pages 14184-14188Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.3c01285
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Myxocoumarin A from Stigmatella aurantiaca MYX-030 exhibits strong antifungal activity against agriculturally relevant pathogens. The total synthesis revealed its stereochemical configuration and demonstrated potent antibacterial activities against certain bacteria.
The myxobacterial natural product myxocoumarin A from Stigmatella aurantiaca MYX-030 has remarkable antifungal activity against agriculturally relevant pathogens. To broaden the initial evaluation of its biological potential, we herein completed the first total synthesis of myxocoumarin A. This synthetic access facilitated stereochemical investigations on the natural product structure, revealing its (R)-configuration. Biological activity profiling showed a lack of activity against Candida spp. and Gram-negative bacteria but revealed strong antibiotic activities against Bacillus subtilis and Staphylococcus aureus, including MRSA.
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