Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 88, Issue 19, Pages 14078-14087Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.3c01598
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A facile and sustainable copper-catalyzed thiolation method has been developed to efficiently construct benzylic thioethers under mild reaction conditions. This approach avoids the use of commonly employed thiolation reagents, making it an attractive method for benzylic thioether synthesis due to the commercial availability of base and reagents, broad substrate scope, and convenient reaction procedure.
A facile copper-catalyzed sustainable thiolation of ketones with sulfonohydrazides has been designed for the efficient construction of benzylic thioethers in excellent yield under mild reaction conditions. The current approach avoids the widely used thiolation reagent, thiols. The commercial availability of the base and reagents, broad substrate scope, and convenient reaction procedure make it an attractive method for benzylic thioether synthesis.
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