Visible-Light Photoredox-Catalyzed Three-Component Reaction of Carbazoles with Alkenes and S-(Difluoromethyl)sulfonium Salt: A Practical Approach to Access Difluoroalkyl-Functionalized Carbazoles

A mild and elegant multicomponent protocol for constructionofCF(2)H-containing carbazoles was accomplished by visible-lightphotoredox catalysis with formation of two new C-C bonds ina single step to deliver a wide variety of structurally diverse difluoroalkylatedcarbazoles in moderate to good yields, featuring mild reaction conditions,synthetic simplicity, broad substrates, and good functional grouptolerance.

Automated summary

A mild and elegant multicomponent protocol for constructing CF(2)H-containing carbazoles was developed using visible-light photoredox catalysis. This single-step reaction delivers a wide variety of structurally diverse difluoroalkylated carbazoles in moderate to good yields. The reaction features mild conditions, synthetic simplicity, broad substrate scope, and good functional group tolerance.