Cu(OTf)2-Phosphoric Acid-Catalyzed Tandem Oxa-Nazarov Cyclization and Dibromination of Conjugated 1,2-Diketones

A facile tandem oxa-Nazarov cyclization and dibromination has been developed. The combination of Cu(OTf)(2) and diphenyl phosphate (DPP-H) was found to synergistically promote the coupling of conjugated 1,2-diketones and N-bromosuccinimide to form 2,4-dibromo-3(2H)-furanones in good yields.

Automated summary

A facile tandem oxa-Nazarov cyclization and dibromination has been developed, in which the combination of Cu(OTf)2 and diphenyl phosphate (DPP-H) synergistically promotes the coupling of conjugated 1,2-diketones and N-bromosuccinimide, leading to the formation of 2,4-dibromo-3(2H)-furanones in good yields.