Gold-Catalyzed Intramolecular Hydroarylation and Transfer Hydrogenation of N-Aryl Propargylamines to Construct Tetrahydroquinolines and 5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolines

A novelprotocol of gold-catalyzed N-aryl propargylaminesto construct tetrahydroquinolines and 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolines in moderate to good yields has beendeveloped through the tandem reactions of intramolecular hydroarylationand transfer hydrogenation. The strategy has the advantages of easyaccess to raw materials, simple reaction conditions, good substratecompatibility, high efficiency, and excellent regioselectivity.

Automated summary

A novel protocol for the synthesis of tetrahydroquinolines and 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolines through gold-catalyzed N-aryl propargylamines has been developed. This strategy offers advantages such as easy access to raw materials, simple reaction conditions, good substrate compatibility, high efficiency, and excellent regioselectivity.