Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 88, Issue 15, Pages 10586-10598Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.3c00604
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Spiro[indoline-3,3′-pyrrolidine] and spiro[indoline-3,3′-piperidine] derivatives were synthesized in a substitution-controlled manner using cationic gold(I) catalyst and Hantzsch ester (HEH). The optimal reaction conditions were determined by screening, and the functional group tolerances of these pathways were examined using synthetic substrates. Density functional theory calculations elucidated the endo and exo selectivities of these cyclizations, and a plausible mechanism for these transformations was proposed.
Spiro[indoline-3,3 & PRIME;-pyrrolidine]and spiro[indoline-3,3 & PRIME;-piperidine] derivativeswere synthesized in a substitution-controlledmanner under the catalysis of cationic gold(I) species in the presenceof Hantzsch ester (HEH). The optimal reaction condition was determinedby screening, and the functional group tolerances of these two pathwayswere examined by readily synthetic substrates. The endo and exo selectivities of these cyclizations wereelucidated by density functional theory calculations, and a plausiblemechanism for these transformations was proposed.
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