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JOURNAL OF ORGANIC CHEMISTRY
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.3c01431
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In this study, a palladium-catalyzed efficient and versatile method for C(sp(2))-H ortho-cyanomethylation of arylamides with a broad substrate scope and moderate to excellent yields was developed. An inexpensive and commercially available chloroacetonitrile was used as the cyanomethylating source. The synthetic feasibility of this technique was also demonstrated by gram-scale synthesis and functional group transformation of the products.
In this study, we devised a palladium-catalyzed efficient and versatile method for C(sp(2))-H ortho-cyanomethylation of arylamides with a broad substrate scope and moderate to excellent yields. An inexpensive and commercially available chloroacetonitrile was employed as a cyanomethylating source. This method is also compatible with the air atmosphere. Further, the synthetic feasibility of this technique is established by gram-scale synthesis and functional group transformation of the products.
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