Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 88, Issue 19, Pages 13466-13474Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.3c00832
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This study describes the HOAc-promoted construction of chroman-4-ones with a sulfur atom and an a-carbonyl quaternary carbon center directly from ortho-hydroxyacetophenones and DMSO. In these reactions, DMSO is activated by HOAc and provides three different units in the target molecules. The reaction displays good substrate scope and reaction yields with a series of substitutes.
HOAc-promoted construction of chroman-4-ones with a sulfur atom and an a-carbonyl quaternary carbon center directly from ortho-hydroxyacetophenones and DMSO is described. In these unique reactions, DMSO is activated by HOAc and provides three different units (CH2, CH2OH, and CH2SMe) in the target molecules. This reaction displays good substrate scope and reaction yields with a series of substitutes. The mechanism showed that the three units were formed in sequential order.
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