Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 88, Issue 21, Pages 15318-15325Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.3c01825
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Four novel compounds were isolated from Conamomum rubidum, including the first examples of monoterpene-monoterpene-chalcone conjugates in nature and an unprecedented monoterpene-substituted chalcone. These compounds exhibited anti-inflammatory and cytotoxic activities.
Four novel compounds, conarubins A-D (1-4), were isolated from the whole plants of Conamomum rubidum collected in Vietnam. Their structures were elucidated by extensive spectroscopic analyses and by quantum chemical calculations of NMR and ECD. Compounds 1 and 2 were the first examples of monoterpene-monoterpene-chalcone conjugates in nature, whereas compound 4 was an unprecedented monoterpene-substituted chalcone containing a 3,4,5-trioxygenated cyclohexa-2,5-diene-1-one ring. The anti-inflammatory and cytotoxic activities of all isolates were investigated.
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