The prognosis of neonatal respiratory status within three years after birth in chronic abruption-oligohydramnios sequence

Review Pediatrics

Inhaled nitric oxide in preterm neonates with preterm prelabour rupture of membranes, a systematic review

Rachel Mullaly et al.

Summary: This systematic literature review examines the effect of inhaled nitric oxide (iNO) on preterm neonates with preterm prelabour rupture of membranes (PPROM) and early hypoxaemic respiratory failure (HRF). The findings suggest that iNO can improve oxygenation when standard care fails, but it may also increase mortality and morbidity, possibly due to the high prevalence of pulmonary hypertension in this cohort.

ACTA PAEDIATRICA (2023)

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Article Obstetrics & Gynecology

Chronic abruption-oligohydramnios sequence (CAOS) revisited: possible implication of premature rupture of membranes

Yoshitsugu Chigusa et al.

Summary: The pathogenic mechanism of chronic abruption-oligohydramnios sequence (CAOS) remains unknown, with no objective standards for diagnosis on imaging or using pathological evidence. This study aimed to clarify the true pathology of CAOS through integration of clinical, magnetic resonance imaging (MRI) and histopathological findings. A retrospective review of clinical data, MRI findings and placental pathology of 18 patients with CAOS between 2010 and 2020 showed preterm birth in 94% of cases, with median gestational age at delivery of 25 weeks. Three neonates (17%) died within two years, and 10 neonates (56%) developed chronic lung disease. MRI revealed intrauterine hematoma and hemorrhagic amniotic fluid, while histopathological findings showed shedding and necrosis of the amniotic epithelium as a characteristic feature in 94% of cases. Diagnosis of diffuse chorionic hemosiderosis (DCH) was confirmed in all cases. The true pathology of CAOS is believed to be premature rupture of membranes rather than chronic abruption, caused by repeated intrauterine hemorrhage and subchorionic hematoma leading to necrosis and weakening of the amnion.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

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Article Obstetrics & Gynecology

The significance of clinical symptoms of subchorionic hematomas, bleeding first, to stratify the high-risk subgroup of very early preterm delivery

Megumi Aki et al.

Summary: This study found that in patients with SCH and persistent vaginal bleeding in early pregnancy, cases where bleeding occurred before hematoma formation were associated with a longer duration of SCH and higher risk of preterm delivery, as well as various complications.

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY (2022)

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Article Developmental Biology

Histological distribution pattern of hemosiderin deposition on the chorionic plate and fetal membrane of diffuse chorioamniotic hemosiderosis related to chronic abruption oligohydramnios sequence

Ayami Ishida et al.

Summary: CAOS cases showed higher levels of hemosiderin deposition in both the chorionic plate (CP) and fetal membrane (FM) compared to control cases. The histological score (HScore) of CP was significantly higher than that of FM, suggesting that CP might be a more suitable site for evaluating diffuse chorioamniotic hemosidemsis (DCH) in CAOS.

PLACENTA (2021)

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Article Obstetrics & Gynecology