Journal
MOLECULAR AND CELLULAR BIOLOGY
Volume 36, Issue 7, Pages 1050-1063Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.00652-15
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Funding
- HHS \ National Institutes of Health (NIH) [GM097360, CA059267]
- American Cancer Society (ACS) [RSG-13-115-01-CCG]
- American Lung Association
- Alex Lemonade Stand Foundation
- Leukemia and Lymphoma Society
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Chromosomal copy number changes are frequently associated with harmful consequences and are thought of as an underlying mechanism for the development of diseases. However, changes in copy number are observed during development and occur during normal biological processes. In this review, we highlight the causes and consequences of copy number changes in normal physiologic processes as well as cover their associations with cancer and acquired drug resistance. We discuss the permanent and transient nature of copy number gains and relate these observations to a new mechanism driving transient site-specific copy gains (TSSGs). Finally, we discuss implications of TSSGs in generating intratumoral heterogeneity and tumor evolution and how TSSGs can influence the therapeutic response in cancer.
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