4.2 Article

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for appendiceal neuroendocrine tumours (aNET)

Journal

JOURNAL OF NEUROENDOCRINOLOGY
Volume -, Issue -, Pages -

Publisher

WILEY
DOI: 10.1111/jne.13332

Keywords

appendiceal NET; follow-up; histopathological features; right hemicolectomy; vascular and lymphatic spread

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The aim of this guidance paper is to provide up-to-date practical guidance for the diagnosis and management of well differentiated appendiceal neuroendocrine tumors (NET). The paper addresses controversial issues and areas of uncertainty, offering recommendations based on the best available evidence and the authors' experiences.
The aim of the present guidance paper is to update the previous ENETS guidelines on well differentiated appendiceal neuroendocrine tumours (NET), providing practical guidance for the diagnosis and management of appendiceal NET (aNET); poorly differentiated neoplasms are dealt with in a separate guidance paper. This paper is structured on a question-answer format in order to also address controversial issues and areas where uncertainty regarding the management and follow-up of aNET exists. All recommendations are offered on the basis of the best available evidence, along with the authors' experiences in managing these neoplasms. Each recommendation for treatment will provide a level of evidence and grade of recommendation as per the GRADE system (adapted in Infectious Disease Society of United States Public Health Service grading system).

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