Journal
JOURNAL OF NEUROCHEMISTRY
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1111/jnc.15985
Keywords
Alzheimer's disease; coronavirus; coronavirus disease 2019; neuropathology
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COVID-19 has the potential to affect the brain and may contribute to the onset or worsening of Alzheimer's disease. The shared pathological features and risk factors between COVID-19 and AD, along with their global impact, could have significant public health consequences.
Coronavirus disease 2019 (COVID-19) has rapidly escalated into a global pandemic that primarily affects older and immunocompromised individuals due to underlying clinical conditions and suppressed immune responses. Furthermore, COVID-19 patients exhibit a spectrum of neurological symptoms, indicating that COVID-19 can affect the brain in a variety of manners. Many studies, past and recent, suggest a connection between viral infections and an increased risk of neurodegeneration, raising concerns about the neurological effects of COVID-19 and the possibility that it may contribute to Alzheimer's disease (AD) onset or worsen already existing AD pathology through inflammatory processes given that both COVID-19 and AD share pathological features and risk factors. This leads us to question whether COVID-19 is a risk factor for AD and how these two conditions might influence each other. Considering the extensive reach of the COVID-19 pandemic and the devastating impact of the ongoing AD pandemic, their combined effects could have significant public health consequences worldwide.
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