Journal
JOURNAL OF NATURAL PRODUCTS
Volume 86, Issue 10, Pages 2270-2282Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.3c00214
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This study investigated the chemical components of avocado seeds and discovered several new alkaloids. The bioactivities of these compounds on SIRT1 were evaluated, and one compound showed the most potent activation effect, suggesting its potential as an anti-aging agent.
Persea americana Mill. (Lauraceae), commonly known as avocado, is a well-known food because of its nutrition and health benefits. The seeds of avocado are major byproducts, and thus their phytochemicals and bioactivities have been of interest for study. The chemical components of avocado seeds were investigated by using UPLC-qTOF-MS/MS-based molecular networking, resulting in the isolation of seven new oxindole alkaloids (1-7) and two new benzoxazinone alkaloids (8 and 9). The chemical structures of the isolated compounds were identified by the analysis of NMR data in combination with computational approaches, including NMR and ECD calculations. Bioactivities of the isolated compounds toward silent information regulation 2 homologue-1 (SIRT1) in HEK293 cells were assessed. The results showed that compound 1 had the most potent effect on SIRT1 activation with an elevated NAD+/NADH ratio with potential for further investigation as an anti-aging agent.
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