Journal
JOURNAL OF NATURAL PRODUCTS
Volume 86, Issue 10, Pages 2326-2332Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.3c00521
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3'-O-ss-Glucosyl-4',5'-didehydro-5'-deoxyadenosine 13 is a natural product of Streptomyces calvus and Streptomyces virens, and can also be generated in vitro by the enzyme NucGT. Experimental results using oxygen-18 and deuterium isotopes confirm that 13 is not a biosynthetic precursor to nucleocidin 1.
3'-O-ss-Glucosyl-4',5'-didehydro-5'-deoxyadenosine 13 is identified as a natural product of Streptomyces calvus and Streptomyces virens. It is also generated in vitro by direct ss-glucosylation of 4',5'didehydro-5'-deoxyadenosine 12 with the enzyme NucGT. The intact incorporation of oxygen-18 and deuterium isotopes from (+/-)[1-O-18,1-H-2(2)]-glycerol 14 into C-5' of nucleocidin 1 and its related metabolites precludes 3'-O-ss-glucosyl- 4',5'-didehydro-5'-deoxyadenosine 13 as a biosynthetic precursor to nucleocidin 1.
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