4.6 Article

New quinazolone derivatives: Synthesis, Spectroscopic, X-ray, DFT calculation and Biological activity studies

Journal

JOURNAL OF MOLECULAR STRUCTURE
Volume 1289, Issue -, Pages -

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ELSEVIER
DOI: 10.1016/j.molstruc.2023.135898

Keywords

Quinazolone; Crystal structure; Synthesis; DFT

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Quinazolone is a heterocyclic scaffold with diverse biological activities, including antidiabetic, antithrombotic, antiviral, antibacterial, and antitumor properties. A new series of quinazolone derivatives, characterized by 1H-NMR, 13C-NMR, HRMS, FT-IR, and X-ray, were designed and synthesized. The density functional theory (DFT) calculation of compound 3f at the B3LYP/6-311 level was also studied. The antitumor activity of all synthesized compounds was evaluated using the MTT assay.
Quinazolone is a type of heterocyclic scaffold with extensively biological activities. Many reports have shown that quinazolone derivatives played an important role as antidiabetic, antithrombotic, antiviral, antibacterial and antitumor reagents. Based on the broadly biological activities, a new series of quinazolone derivatives was designed and synthesized. These compounds were characterized by 1H-NMR, 13C-NMR and HRMS. Especially, compound 3f was cultured into single crystals, and the structure of compound 3f was also characterized by FT-IR and X-ray. In addition, the density functional theory (DFT) calculation of compound 3f was studied at the B3LYP/ 6-311 level. Finally, the antitumor activity of all the target compounds was evaluated by MTT assay.

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