Syncytin-1, syncytin-2 and suppressyn in human health and disease

In this review, we summarized the results of experimental and clinical studies about three human endogenous retroviruses and their products-syncytin-1, syncytin-2, and suppressyn in human physiology and pathophysiology. We summed up the described connection with various pathological processes and diseases, mainly with pregnancy-induced hypertensive diseases such as preeclampsia, oncogenesis, gestational trophoblastic disease, and multiple sclerosis. Supposed mechanisms of action and the potential of clinical applications are also described.

Automated summary

In this review, we summarized the results of studies on three human endogenous retroviruses and their products, syncytin-1, syncytin-2, and suppressyn, in human physiology and pathophysiology. We discussed their connection with various pathological processes and diseases, mainly focusing on pregnancy-induced hypertensive diseases such as preeclampsia, oncogenesis, gestational trophoblastic disease, and multiple sclerosis. The potential mechanisms of action and clinical applications are also described.