Microwave-assisted rapid catalytic degradation of isoniazid drug using polythiophene/ZnFe2O4 organic-inorganic hybrids

This present work reports for the first time, microwave-assisted catalytic degradation of isoniazid drug using organic-inorganic hybrids of polythiophene (PTh) decorated ZnFe2O4 nanoparticles. The hybrids were characterized using fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscopy along with energy dispersive spectra (SEM-EDS). The nanohybrids were used as catalysts for the degradation of isoniazid (ISN) drug under microwave irradiation. Almost 94% degradation of isoniazid was attained within 24 min using 100 mg of the catalyst. The degraded drug fragments were analyzed using LCMS and a tentative mechanism of degradation was proposed.

Automated summary

This study reports for the first time the microwave-assisted catalytic degradation of isoniazid drug using organic-inorganic hybrids of PTh decorated ZnFe2O4 nanoparticles. The nanohybrids demonstrated high efficiency in degrading the drug within a short period of time, and a tentative mechanism of degradation was proposed.