Tnni3k influences cardiomyocyte S-phase activity and proliferation

Article Developmental Biology

Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds

Samantha K. Swift et al.

Summary: Somatic polyploidization is an adaptation observed in many cell types, including cardiomyocytes, where cells increase their DNA content to support growth. However, the progression to a polyploid state often leads to the loss of proliferative capacity. Recent research shows that genetics play a significant role in cardiomyocyte ploidy, but the developmental course to reach the final ploidy state has only been studied in select backgrounds.

DEVELOPMENT (2023)

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Article Cardiac & Cardiovascular Systems

Cardiac Troponin I-Interacting Kinase Affects Cardiomyocyte S-Phase Activity but Not Cardiomyocyte Proliferation

Sean P. Reuter et al.

Summary: Genetic analysis found that Tnni3k expression increases cardiomyocyte S-phase activity after injury. This study may help guide the development of therapeutic interventions for cardiac regeneration.

CIRCULATION (2023)

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Review Cardiac & Cardiovascular Systems

Measuring cardiomyocyte cell-cycle activity and proliferation in the age of heart regeneration

John Auchampach et al.

Summary: The field of mammalian myocardial regeneration has seen significant growth in the past two decades. However, there are limitations and challenges in characterizing cardiomyocyte proliferation. Claims of cardiomyocyte proliferation often lack sufficient evidence or proper controls, and the provided data may only indicate cell-cycle activation or DNA synthesis, without proving the generation of new cardiomyocytes. Rigorous experimental strategies and standards should be used to support claims of proliferation-based remuscularization.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2022)

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Article Multidisciplinary Sciences

Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle

Xiuxiu Liu et al.

Summary: Cardiac regeneration involves the generation of new cardiomyocytes from cycling cardiomyocytes, with a subset of cycling cardiomyocytes identified as undergoing cell division. Regional patterns of cycling cardiomyocytes are induced by myocardial infarction and cardiac pressure overload. The Hippo pathway effector YAP is required for cardiomyocyte cell cycle activity.

NATURE COMMUNICATIONS (2021)

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Correction Cell Biology