Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 183, Issue -, Pages 22-26Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2023.08.004
Keywords
Cardiomyocyte; Polyploidization; Proliferation; Heart regeneration
Categories
Ask authors/readers for more resources
We conducted a retrospective analysis of single cell ventricular suspensions to identify cardiomyocytes that have completed cell division. Our findings indicate that the ability of cardiomyocytes to re-enter the cell cycle and complete cell division after injury is independent and variable. Additionally, we provide evidence that Tnni3k influences both early and final stages of the cell cycle.
Cardiomyocyte proliferation is a difficult phenomenon to capture and prove. Here we employ a retrospective analysis of single cell ventricular suspensions to definitively identify cardiomyocytes that have completed cell division. Through this analysis we determined that the capacity of cardiomyocytes to re-enter the cell cycle and complete cell division after injury are separate and variable traits. Further, we provide evidence that Tnni3k definitively influences both early and final stages of the cell cycle.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available