4.7 Article

Synthesis, Preclinical Evaluation, and First-in-Human PET Study of [68Ga]-Labeled Biphenyl-Containing PSMA Tracers

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Imageological/Structural Study regarding the Improved Pharmacokinetics by 68Ga-Labeled PEGylated PSMA Multimer in Prostate Cancer

Huihui Zhang et al.

Summary: This study reported a series of Ga-68/Lu-177-labeled multimer PSMA tracer conjugating with PEG chain, which provides a new option for diagnosing and treating prostate cancer. The results showed that PEG(4) and PSMA dimer optimizations enhanced the probes' tumor-targeting ability in PC-3 PIP tumor-bearing mice models.

PHARMACEUTICALS (2023)

Article Oncology

Recent Advances in the Management of Metastatic Prostate Cancer

Soo Yeon Kim et al.

Summary: The management of metastatic prostate cancer has undergone a revolution with the introduction of new agents and the repurposing of existing ones. These novel therapies have shown improved outcomes and have received approval. The ongoing investigation of multiple new agents is expected to further improve survival outcomes for patients in the coming years.

JCO ONCOLOGY PRACTICE (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

68Ga-labeled ODAP-Urea-based PSMA agents in prostate cancer: first-in-human imaging of an optimized agent

Xiaojiang Duan et al.

Summary: PSMA is a promising target for prostate cancer imaging and therapy. The ODAP-Urea-based ligand [Ga-68] Ga-P137 has potential for imaging in both mice and humans, showing lower bladder accumulation compared to the Glu-Urea-based agent [Ga-68] Ga-PSMA-617.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2022)

Article Pharmacology & Pharmacy

Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands

Fanny Lundmark et al.

Summary: This study presents the design, synthesis, and evaluation of 11 PSMA-binding radioligands with modified linker structures, aiming to understand the relationship between molecular structure and targeting properties. The results suggest that 2-naphthyl-L-alanine is crucial for good targeting properties, while tranexamic acid can be replaced by other substituents.

PHARMACEUTICS (2022)

Article Chemistry, Medicinal

New PSMA-Targeting Ligands: Transformation from Diagnosis (Ga-68) to Radionuclide Therapy (Lu-177)

Zhihao Zha et al.

Summary: This study successfully transformed a PSMA-targeting imaging agent into promising radionuclide therapeutic agents using Lu-177 isotope. Both newly developed agents showed excellent PSMA binding affinity and exhibited good tumor uptake and blood clearance in a mouse model. One of the agents also demonstrated an extended blood half-life and longer tumor residence time.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Head-to-Head Comparison of 68Ga-NOTA (68Ga-NGUL) and 68Ga-PSMA-11 in Patients with Metastatic Prostate Cancer: A Prospective Study

Minseok Suh et al.

Summary: Ga-68-NGUL demonstrated lower uptake in normal organs, rapid urinary clearance, similar performance in detecting PSMA-avid primary and metastatic lesions compared to Ga-68-PSMA-11, but a relatively lower tumor-to-background ratio.

JOURNAL OF NUCLEAR MEDICINE (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Preclinical comparison of four [18F, natGa]rhPSMA-7 isomers: influence of the stereoconfiguration on pharmacokinetics

Alexander Wurzer et al.

EJNMMI RESEARCH (2020)

Review Radiology, Nuclear Medicine & Medical Imaging

Evans Blue Dye: A Revisit of Its Applications in Biomedicine

Linpeng Yao et al.

CONTRAST MEDIA & MOLECULAR IMAGING (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

Diagnostic performance of 68Ga-PSMA-11 (HBED-CC) PET/CT in patients with recurrent prostate cancer: evaluation in 1007 patients

Ali Afshar-Oromieh et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2017)

Review Biochemical Research Methods

Albumin-Binding Evans Blue Derivatives for Diagnostic Imaging and Production of Long-Acting Therapeutics

Orit Jacobson et al.

BIOCONJUGATE CHEMISTRY (2016)

Article Radiology, Nuclear Medicine & Medical Imaging

The Rise of PSMA Ligands for Diagnosis and Therapy of Prostate Cancer

Ali Afshar-Oromieh et al.

JOURNAL OF NUCLEAR MEDICINE (2016)

Article Radiology, Nuclear Medicine & Medical Imaging

PSMA-Targeted Radionuclide Therapy of Metastatic Castration-Resistant Prostate Cancer with 177Lu-Labeled PSMA-617

Clemens Kratochwil et al.

JOURNAL OF NUCLEAR MEDICINE (2016)

Article Radiology, Nuclear Medicine & Medical Imaging

Preclinical Evaluation of a Tailor-Made DOTA-Conjugated PSMA Inhibitor with Optimized Linker Moiety for Imaging and Endoradiotherapy of Prostate Cancer

Martina Benesova et al.

JOURNAL OF NUCLEAR MEDICINE (2015)

Review Medicine, Research & Experimental

PSMA Ligands for Radionuclide Imaging and Therapy of Prostate Cancer: Clinical Status

Susanne Lutje et al.

THERANOSTICS (2015)

Article Radiology, Nuclear Medicine & Medical Imaging

Synthesis and preclinical evaluation of DOTAGA-conjugated PSMA ligands for functional imaging and endoradiotherapy of prostate cancer

Martina Weineisen et al.

EJNMMI RESEARCH (2014)

Article Biochemical Research Methods

68Ga-Complex Lipophilicity and the Targeting Property of a Urea-Based PSMA Inhibitor for PET Imaging

Matthias Eder et al.

BIOCONJUGATE CHEMISTRY (2012)

Article Radiology, Nuclear Medicine & Medical Imaging

A dimerized urea-based inhibitor of the prostate-specific membrane antigen for Ga-68-PET imaging of prostate cancer

Martin Schaefer et al.

EJNMMI RESEARCH (2012)

Article Radiology, Nuclear Medicine & Medical Imaging

Dynamic Contrast-enhanced CT for Prostate Cancer: Relationship between Image Noise, Voxel Size, and Repeatability

Johannes G. Korporaal et al.

RADIOLOGY (2010)

Article Radiology, Nuclear Medicine & Medical Imaging

18F-labeled mini-PEG spacered RGD dimer (18F-FPRGD2):: synthesis and microPET imaging of αvβ3 integrin expression

Zhanhong Wu et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2007)

Article Radiology, Nuclear Medicine & Medical Imaging

Production of multimeric prostate-specific membrane antigen small-molecule radiotracers using a solid-phase 99mTc preloading strategy

Preeti Misra et al.

JOURNAL OF NUCLEAR MEDICINE (2007)

Article Multidisciplinary Sciences

Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase

MI Davis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Probing for a hydrophobic a binding register in prostate-specific membrane antigen with phenylalkylphosphonamidates

J Maung et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2004)