Related references
Note: Only part of the references are listed.Anti-trypanosomatid drug discovery: progress and challenges
Manu De Rycker et al.
NATURE REVIEWS MICROBIOLOGY (2023)
Anti-trypanosomatid drug discovery: progress and challenges
Manu De Rycker et al.
NATURE REVIEWS MICROBIOLOGY (2023)
The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targets
Fernando Altamura et al.
DRUG DEVELOPMENT RESEARCH (2022)
New global targets for NTDs in the WHO roadmap 2021-2030
Adriano Casulli
PLOS NEGLECTED TROPICAL DISEASES (2021)
Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics
Dana M. Klug et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
C6-O-alkylated 7-deazainosine nucleoside analogues: Discovery of potent and selective anti-sleeping sickness agents
Fabian Hulpia et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice
Andreas K. Lindner et al.
LANCET INFECTIOUS DISEASES (2020)
Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors
Baljinder Singh et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi
Julien Pedron et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History
Harry P. De Koning
TROPICAL MEDICINE AND INFECTIOUS DISEASE (2020)
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform
Carolina B. Moraes et al.
SLAS DISCOVERY (2019)
Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-innidazole Derivatives as Antiprotozoal Agents
Francesco Saccoliti et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development
Kelly A. Bachoychin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness
Fabian Hulpia et al.
NATURE COMMUNICATIONS (2019)
Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity
Antoni R. Blaazer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation
Jennifer L. Woodring et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
Mark C. Field et al.
NATURE REVIEWS MICROBIOLOGY (2017)
The single cyclic nucleotide-specific phosphodiesterase of the intestinal parasite Giardia lamblia represents a potential drug target
Stefan Kunz et al.
PLOS NEGLECTED TROPICAL DISEASES (2017)
Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target
Thavy Long et al.
PLOS NEGLECTED TROPICAL DISEASES (2017)
Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei
Susan Wyllie et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2016)
Identification of Potent Phosphodiesterase Inhibitors that Demonstrate Cyclic Nucleotide-Dependent Functions in Apicomplexan Parasites
Brittany L. Howard et al.
ACS CHEMICAL BIOLOGY (2015)
Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library
Andrew Woodland et al.
CHEMMEDCHEM (2015)
Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose
Darren J. Creek et al.
PLOS PATHOGENS (2015)
Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis
Advait S. Nagle et al.
CHEMICAL REVIEWS (2014)
Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure
Chimed Jansen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Pharmacological Validation of Trypanosoma brucei Phosphodiesterases as Novel Drug Targets
Harry P. de Koning et al.
JOURNAL OF INFECTIOUS DISEASES (2012)
Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei
Isabel M. Vincent et al.
PLOS NEGLECTED TROPICAL DISEASES (2012)
Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters
Gabriela Schumann Burkard et al.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2011)
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
Jonathan B. Baell et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes
Isabel M. Vincent et al.
PLOS PATHOGENS (2010)
The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents
Michael P. DeNinno et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes
Shane R. Wilkinson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors
Huanchen Wang et al.
MOLECULAR MICROBIOLOGY (2007)
The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2:: flagellar enzymes that are essential for parasite virulence
Michael Oberholzer et al.
FASEB JOURNAL (2007)
The chemical development of the commercial route to sildenafil: A case history
DJ Dale et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2000)
Share Paper
