Related references
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Letter
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Summary: Recombination is the main driver of RNA virus evolution, and during the pandemic, SARS-CoV-2 produced several recombinants. The most recent recombinant, XBB or Gryphon, is a combination of BJ.1 and BM.1.1.1 lineages. Genetic analysis revealed that XBB and its descendant XBB.1 have slightly higher genetic variability and expansion capabilities compared to their parental lineages. However, they do not currently pose a specific danger or have high expansion capabilities. Ongoing genome-based monitoring is necessary to identify if further mutations in XBB could increase its danger or generate new subvariants with different expansion capabilities.
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Review
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Summary: The debate over the origin of SARS-CoV-2 continues, with no solid evidence to support the theory that it is man-made and lab-leak theories remaining speculative. The consensus is that the pandemic likely originated from a natural source and further research is needed to determine the true origin of the virus.
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Summary: During the COVID-19 pandemic, the B.1.617.2/Delta variant has been found to be highly fusogenic and more pathogenic in infected hamsters compared to prototypic SARS-CoV-2. The P681R mutation in the spike protein of this variant enhances viral fusogenicity and pathogenicity.
Article
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Summary: This study reports that the P681R mutation in the Delta spike plays a crucial role in the replacement of the Alpha variant by the Delta variant during the COVID-19 pandemic. The Delta variant outcompetes the Alpha variant in human lung cells and airway tissues. The P681R mutation enhances the cleavage of the spike protein, leading to increased replication of the Delta variant.
Review
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NATURE REVIEWS MICROBIOLOGY
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