Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 228, Issue 6, Pages 800-809Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiad253
Keywords
humanized mice; intraperitoneal infection; pulmonary infection; skin infection; Staphylococcus aureus
Categories
Ask authors/readers for more resources
Staphylococcus aureus is a significant human pathogen that can cause a wide range of diseases. Conventional mouse studies lack predictive ability due to the differences in immune systems between mice and humans. Humanized mice provide a promising model for studying human-specific virulence factors and the interaction mechanisms of S. aureus with humans.
Staphylococcus aureus (S. aureus) is an important pathogen for humans and can cause a wide range of diseases, from mild skin infections, severe osteomyelitis to fatal pneumonia, sepsis, and septicemia. The mouse models have greatly facilitated the development of S. aureus studies. However, due to the substantial differences in immune system between mice and humans, the conventional mouse studies are not predictive of success in humans, in which case humanized mice may overcome this limitation to some extent. Humanized mice can be used to study the human-specific virulence factors produced by S. aureus and the mechanisms by which S. aureus interacts with humans. This review outlined the latest advances in humanized mouse models used in S. aureus studies. Staphylococcus aureus is a dangerous human pathogen and humanized mice can overcome various limitations of traditional mice to better translate in vivo findings to humans, and are thus a promising mouse model.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available