4.5 Review

Length of intensive care unit stay and the apparent efficacy of antimicrobial-based versus non- antimicrobial-based ventilator pneumonia prevention interventions within the Cochrane review database

Related references

Note: Only part of the references are listed.
Article Infectious Diseases

Staphylococcus aureus hitchhiking from colonization to bacteremia via Candida within ICU infection prevention studies: a proof of concept modelling

James C. Hurley

Summary: The study investigates the interaction between Candida and Staphylococcus colonization in the pathogenesis of bacteremia. The results show that the co-colonization of Candida and Staphylococcus improves the model fit, and the model coefficients related to exposure to antibacterial and antifungal agents are contrary to Candida colonization. However, the coefficients related to exposure to antibacterial and antifungal agents are weaker in their association with Staphylococcus colonization.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2023)

Article Medicine, Research & Experimental

Establishing the safety of selective digestive decontamination within the ICU population: a bridge too far?

James C. Hurley

Summary: In this study, the researchers investigated the effectiveness of infection prevention interventions within the ICU setting. They found that selective digestive decontamination (SDD) was highly effective in preventing ICU infections. However, the results differed significantly when comparing randomized controlled trials with cluster randomized trials, suggesting a possible spillover effect of SDD.

TRIALS (2023)

Editorial Material Critical Care Medicine

Selective digestive decontamination-Con

James C. Hurley

INTENSIVE CARE MEDICINE (2023)

Review Medicine, General & Internal

Association Between Selective Decontamination of the Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation A Systematic Review and Meta-analysis

Naomi E. Hammond et al.

Summary: Comparing SDD with standard care in mechanically ventilated adults in the ICU, it was found that SDD is associated with reduced hospital mortality and decreased risk of ventilator-associated pneumonia and ICU-acquired bacteremia.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

Article Critical Care Medicine

Selective digestive decontamination, a seemingly effective regimen with individual benefit or a flawed concept with population harm?

James C. Hurley

Summary: Selective digestive decontamination (SDD) regimens, including topical antibiotic prophylaxis (TAP) and protocolized parenteral antibiotic prophylaxis (PPAP), are highly effective in preventing ICU-acquired infections within randomized concurrent control trials. The concept of SDD suggests potential population benefit, but natural experiments using non-concurrent controls indicate overall population harm associated with higher event rates in the ICU context with SDD use.

CRITICAL CARE (2021)

Article Immunology

How the Cluster-randomized Trial Works

James C. Hurley

CLINICAL INFECTIOUS DISEASES (2020)

Review Public, Environmental & Occupational Health

Risk of organism acquisition from prior room occupants: a systematic review and meta-analysis

B. G. Mitchell et al.

JOURNAL OF HOSPITAL INFECTION (2015)

Review Critical Care Medicine

Selective decontamination of the digestive tract: the mechanism of action is control of gut overgrowth

Luciano Silvestri et al.

INTENSIVE CARE MEDICINE (2012)

Article Immunology

Herd Immunity'': A Rough Guide

Paul Fine et al.

CLINICAL INFECTIOUS DISEASES (2011)

Review Public, Environmental & Occupational Health

The Role Played by Contaminated Surfaces in the Transmission of Nosocomial Pathogens

Jonathan A. Otter et al.

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY (2011)

Article Infectious Diseases

New approaches to the assessment of vaccine herd protection in clinical trials

John Clemens et al.

LANCET INFECTIOUS DISEASES (2011)

Article Critical Care Medicine

Ecological Effects of Selective Decontamination on Resistant Gram-negative Bacterial Colonization

Evelien A. N. Oostdijk et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)

Article Medicine, General & Internal

Decontamination of the Digestive Tract and Oropharynx in ICU Patients

A. M. G. A. de Smet et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Immunology

Molecular epidemiology of candidemia:: Evidence of clusters of smoldering nosocomial infections

Lena Ros Asmundsdottir et al.

CLINICAL INFECTIOUS DISEASES (2008)