4.7 Article

Maternal exposure to dibutyl phthalate regulates MSH6 crotonylation to impair homologous recombination in fetal oocytes

Related references

Note: Only part of the references are listed.
Article Engineering, Environmental

Dibutyl phthalate induced oxidative stress and genotoxicity on adult zebrafish (Danio rerio) brain

Nan Jiang et al.

Summary: The study found that low concentrations of DBP can cause oxidative damage and genotoxicity in the zebrafish brain, demonstrating clear toxic effects. Assessment of DBP's toxic effects on zebrafish brain can be effectively evaluated by measuring biomarkers such as SOD and CAT activities.

JOURNAL OF HAZARDOUS MATERIALS (2022)

Article Environmental Sciences

Fetal exposure of Aristolochic Acid I undermines ovarian reserve by disturbing primordial folliculogenesis

Liu Qiqi et al.

Summary: This study reveals the detrimental effects of AAI on neonatal mouse ovarian development and adult female fertility. Offspring of pregnant mice exposed to AAI displayed abnormal ovarian development, increased DNA damage in oocytes, and reduced fertility in adulthood.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Review Biochemistry & Molecular Biology

Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration?

Erin L. Sternburg et al.

Summary: RNA-binding proteins play critical roles in RNA expression and metabolism, and their proper regulation is essential for cellular health. Regulation of RBPs often occurs through post-translational modifications (PTMs), allowing cells to respond efficiently to various stimuli. Recent studies have shown that PTMs are important regulators of RBPs associated with neurodegenerative disorders like ALS and FTD, influencing their biophysical properties, molecular interactions, subcellular localization, and function. The roles of PTMs in these neurodegenerative disorders can be pathological, protective, or ambiguous.

TRENDS IN BIOCHEMICAL SCIENCES (2022)

Review Chemistry, Analytical

Phthalate esters in marine ecosystems: Analytical methods, occurrence and distribution

Miriam Hidalgo-Serrano et al.

Summary: Phthalate esters, widely used in the plastics industry as additives, are high production volume chemicals that can easily leach into the environment. They have been found to have negative effects on marine biota, making them an emerging concern. This article reviews the important analytical methods for determining phthalate esters in seawater, marine sediments, and biota, as well as their occurrence and distribution in the marine environment.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2022)

Article Environmental Sciences

Single-cell transcriptomic profiling to evaluate the effects of Di(2-ethylhexyl)phthalate exposure on early meiosis of female mouse germ cells

Yu Tian et al.

Summary: DEHP exposure affects the meiotic process in mouse embryonic ovaries, leading to DNA damage and altered signal transduction. These findings provide a theoretical basis for the prevention and treatment of female reproductive health problems caused by DEHP.

CHEMOSPHERE (2022)

Article Biochemistry & Molecular Biology

Dynamic switching of crotonylation to ubiquitination of H2A at lysine 119 attenuates transcription-replication conflicts caused by replication stress

Shuailin Hao et al.

Summary: Protein reversible post-translational modification (PTM) plays a crucial role in cellular processes. Lysine crotonylation (Kcr), a newly identified PTM, is found to be involved in replication stress response. The modification of histone H2A at lysine 119 (H2AK119) by crotonylation and ubiquitination specifically regulates transcription-replication conflicts (TRCs), protecting genome stability under replication stress.

NUCLEIC ACIDS RESEARCH (2022)

Article Genetics & Heredity

Failure to recombine is a common feature of human oogenesis

Terry Hassold et al.

Summary: Failure of homologous chromosomes to recombine is a significant cause of human meiotic nondisjunction, particularly in maternal origin trisomies. Studies have found high levels of recombination failure in fetal ovarian samples, with a preponderance of MLH1-less homologs involving chromosomes 21 or 22. The presence of exchangeless chromosomes in cells is associated with a reduction in the total number of crossovers, indicating individuals with lower rates of meiotic recombination may be at increased risk of producing aneuploid offspring.

AMERICAN JOURNAL OF HUMAN GENETICS (2021)

Article Biochemistry & Molecular Biology

De novo deletions and duplications at recombination hotspots in mouse germlines

Agnieszka Lukaszewicz et al.

Summary: Numerous DNA double-strand breaks arise during meiosis to initiate homologous recombination. A distinct type of mutational event involves deletions formed by joining ends from closely spaced DSBs within single or adjacent hotspots. In the absence of the ATM kinase, these deletions are more frequent and may lead to insertional mutagenesis.
Article Environmental Sciences

Effect of polystyrene on di-butyl phthalate (DBP) bioavailability and DBP-induced phytotoxicity in lettuce

Minling Gao et al.

Summary: This study investigated the toxic effects of small and large polystyrene microplastics on lettuce under di-butyl phthalate stress. The results showed that microplastics, especially in combination with DBP, could decrease lettuce biomass, induce oxidative stress, and exacerbate subcellular damage. Additionally, PS adhered to root surfaces and caused physical blockage of root pores, leading to cell membrane and wall damage. Molecular docking revealed interactions between DBP and monobutyl phthalate with superoxide dismutase residues. Moreover, there was no statistical difference in phytotoxicity between nano- and microplastics on lettuce, with PS aggravating DBP-induced phytotoxicity.

ENVIRONMENTAL POLLUTION (2021)

Article Biology

ATM and ATR Activation Through Crosstalk Between DNA Damage Response Pathways

Elizabeth A. Fedak et al.

Summary: Cells losing the ability to self-regulate in response to damage is a hallmark of cancer, with regulatory pathways determining repair, cell cycle arrest, or apoptosis. The complexity arises from reconciling different signals, such as crosstalk between repair pathways and pro-apoptotic signaling kinases, influenced by damage by-products. The mathematical model of ATM/ATR crosstalk provides evidence for holistic approaches to pro-apoptotic signaling rather than attributing it to a single dominant kinase.

BULLETIN OF MATHEMATICAL BIOLOGY (2021)

Review Pharmacology & Pharmacy

Reproductive toxic potential of phthalate compounds - State of art review

Sapna Sedha et al.

Summary: Phthalates, pervasive compounds widely used in various products, have been linked to developmental and reproductive toxicity, highlighting the importance of developing non-toxic alternatives to reduce risks of exposure. More epidemiological studies are needed to further understand the impact of phthalates on human health.

PHARMACOLOGICAL RESEARCH (2021)

Article Environmental Sciences

Multi- and Transgenerational Outcomes of an Exposure to a Mixture of Endocrine-Disrupting Chemicals (EDCs) on Puberty and Maternal Behavior in the Female Rat

David Lopez-Rodriguez et al.

Summary: The study found that female rats exposed to EDC mixtures may experience disruptions in sexual maturation and maternal care in multiple generations, possibly through epigenetic reprogramming of the hypothalamus.

ENVIRONMENTAL HEALTH PERSPECTIVES (2021)

Article Environmental Sciences

Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells

Wen Liu et al.

Summary: The study shows that phthalates disrupt the circadian rhythm in both adult fruit flies and human cells, affecting the expression of genes related to circadian rhythm regulation and potentially promoting cell proliferation and migration ability.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Review Cell Biology

Protein lysine crotonylation: past, present, perspective

Gaoyue Jiang et al.

Summary: Lysine crotonylation, discovered in both histone and non-histone proteins, is involved in various diseases and biological processes. Unique in its carbon-carbon pi-bond structure, lysine crotonylation may utilize distinct regulatory mechanisms and has interactions with other types of modifications. Tools and methods for predicting and detecting lysine crotonylation have also been discussed.

CELL DEATH & DISEASE (2021)

Article Biotechnology & Applied Microbiology

Pregnancy exposure of titanium dioxide nanoparticles causes intestinal dysbiosis and neurobehavioral impairments that are not significant postnatally but emerge in adulthood of offspring

Junhao Su et al.

Summary: The study revealed that exposure to TiO(2)NPs during pregnancy can cause delayed appearance of neurobehavioral impairments in offspring when they reach adulthood, even though these effects did not occur in the early stages of life after delivery.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Article Cell Biology

In utero Exposure to Excessive Estrogen Impairs Homologous Recombination and Oogenesis via Estrogen Receptor 2 in Mice

Xinyi Mu et al.

Summary: This study shows that in utero estrogen exposure can affect early oogenesis and reproductive potential of female offspring. 17-beta-estradiol induces aberrations in meiotic fetal oocytes, mainly mediated by estrogen receptor 2 (ESR2) activation. Maternal exposure to ESR2-activating substances may compromise the fertility of the exposed female fetus.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Protein phosphatase 6 is a key factor regulating spermatogenesis

Wen-Long Lei et al.

CELL DEATH AND DIFFERENTIATION (2020)

Article Multidisciplinary Sciences

Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health

Jessica M. Stringer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Engineering, Environmental

A Novel Mechanism of Monoethylhexyl Phthalate in Lipid Accumulation via Inhibiting Fatty Acid Beta-Oxidation on Hepatic Cells

Tengfei Xu et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2020)

Article Materials Science, Multidisciplinary

Molecular Imprinted Poly-Cyclodextrin for Selective Removal of Dibutyl Phthalate

Jayanta Dolai et al.

ACS APPLIED POLYMER MATERIALS (2020)

Article Biochemistry & Molecular Biology

L3MBTL2 regulates chromatin remodeling during spermatogenesis

Chenling Meng et al.

CELL DEATH AND DIFFERENTIATION (2019)

Article Endocrinology & Metabolism

Neurochemical alterations following the exposure to di-n-butyl phthalate in rats

Rami B. Kassab et al.

METABOLIC BRAIN DISEASE (2019)

Article Engineering, Environmental

Foetal-neonatal exposure of Di (2-ethylhexyl) phthalate disrupts ovarian development in mice by inducing autophagy

Yan Zhang et al.

JOURNAL OF HAZARDOUS MATERIALS (2018)

Article Cell & Tissue Engineering

Dynamics of Telomere Rejuvenation during Chemical Induction to Pluripotent Stem Cells

Haifeng Fu et al.

STEM CELL REPORTS (2018)

Article Biochemistry & Molecular Biology

The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure

Vera D. Rinaldi et al.

MOLECULAR CELL (2017)

Article Multidisciplinary Sciences

BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing

Weixing Zhao et al.

NATURE (2017)

Review Endocrinology & Metabolism

Environmental influences on ovarian dysgenesis - developmental windows sensitive to chemical exposures

Hanna Katarina Lilith Johansson et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

Review Cell Biology

Non-homologous DNA end joining and alternative pathways to double-strand break repair

Howard H. Y. Chang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Article Multidisciplinary Sciences

A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination

H. B. D. Prasada Rao et al.

SCIENCE (2017)

Letter Cell Biology

Global profiling of crotonylation on non-histone proteins

Weizhi Xu et al.

CELL RESEARCH (2017)

Review Genetics & Heredity

Mismatch repair and homeologous recombination

Khek-Chian Tham et al.

DNA REPAIR (2016)

Review Environmental Sciences

The effects of phthalates in the cardiovascular and reproductive systems: A review

Melissa Mariana et al.

ENVIRONMENT INTERNATIONAL (2016)

Review Cell Biology

Repair Pathway Choices and Consequences at the Double-Strand Break

Raphael Ceccaldi et al.

TRENDS IN CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

Benjamin R. Sabari et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer

Rajat Banerjee et al.

NATURE COMMUNICATIONS (2014)

Article Cell Biology

DNA Damage Sensing by the ATM and ATR Kinases

Alexandre Marechal et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Editorial Material Cell Biology

Meiotic DSBs and the control of mammalian recombination

Kenneth Paigen et al.

CELL RESEARCH (2012)

Article Obstetrics & Gynecology

Environment and women's reproductive health

D. Caserta et al.

HUMAN REPRODUCTION UPDATE (2011)

Article Biochemistry & Molecular Biology

The quantitative proteome of a human cell line

Martin Beck et al.

MOLECULAR SYSTEMS BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair

Ankita Shahi et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Biochemistry & Molecular Biology

Structure of the human MutSα DNA lesion recognition complex

Joshua J. Warren et al.

MOLECULAR CELL (2007)

Review Cell Biology

The multifaceted mismatch-repair system

J Jiricny

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Review Chemistry, Multidisciplinary

Protein posttranslational modifications: The chemistry of proteome diversifications

CT Walsh et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)

Article Biochemistry & Molecular Biology

Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutSα mismatch-binding activity

M Christmann et al.

NUCLEIC ACIDS RESEARCH (2002)