Occurrence, placental transfer, and health risks of emerging endocrine-disrupting chemicals in pregnant women

Previous studies demonstrated that many environmental chemicals can cross the human placental barrier. However, the risk regarding gestational exposure of emerging endocrine-disrupting chemicals (EDCs) is unclear. In this study, the occurrence of 24 EDCs, such as bisphenol A analogs, parabens, triclocarban, and triclosan, was investigated in serum and urine samples from Chinese pregnant women. Some metabolites were determined in matched serum-urine pairs (n = 75) to perform a comprehensive assessment of exposure. The placental transfer efficiency (PTE) of the detected chemicals was determined in matched maternal-cord serum pairs (n = 110). The mean PTEs of the chemicals showed a large variation from 43.1% to 171.0%. The potential effects of physicochemical properties, molecular structures, and biological factors on PTE were investigated using multiple linear regression models and molecular docking. We found that the PTE of methyl paraben, ethyl paraben, and propyl paraben was associated with their increasing alkyl chain lengths. Furthermore, a comprehensive exposure assessment of EDCs showed that 62.7% of pregnant women had a health index > 1, which indicted potential health risks during pregnancy. However, toxicity and the underlying mechanisms of these EDCs remain to be further studied.

Automated summary

This study investigated the occurrence of 24 emerging endocrine-disrupting chemicals (EDCs) in serum and urine samples from Chinese pregnant women. The placental transfer efficiency (PTE) of the detected chemicals was determined and factors influencing PTE were analyzed. The study revealed that certain parabens had higher PTE with increasing alkyl chain lengths, and a comprehensive assessment showed potential health risks for the majority of pregnant women.