Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 457, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jhazmat.2023.131741
Keywords
Oxidative damage; Weizmannia coagulans; Intestinal flora; Serum metabolites; Caenorhabditis elegans
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This study investigated the mechanisms of Bacillus coagulans (Weizmannia coagulans) XY2 against Cu-induced oxidative stress using a dual model. Cu disrupted the microbial community structure, while XY2 intervention reversed this trend and alleviated Cu-induced metabolic disturbances. In addition, XY2 mitigated the oxidative damage caused by Cu exposure through regulating DAF-16/FoxO and SKN-1/Nrf2 pathways and intestinal flora. This research provides a theoretical basis for formulating future strategies of probiotics against heavy metal contamination.
Copper (Cu) pollution has become a serious environmental problem especially in recent decades. In this study, the mechanisms of Bacillus coagulans (Weizmannia coagulans) XY2 against Cu-induced oxidative stress were explored through a dual model. In mice, Cu disturbed microbial community structure, revealing an increased level of Enterorhabdus abundance and decreased levels of Intestinimonas, Faecalibaculu, Ruminococcaceae and Coriobacteriaceae_UCG-002 abundance. Meanwhile, B. coagulans (W. coagulans) XY2 intervention reversed this trend along with alleviated Cu-induced metabolic disturbances by increasing levels of hypotaurine and Lglutamate and declining levels of phosphatidylcholine and phosphatidylethanolamine. In Caenorhabditis elegans, nuclear translocation of DAF-16 and SKN-1 was inhibited by Cu, which in turn suppressed antioxidant-related enzymes activities. XY2 mitigated biotoxicity associated with oxidative damage caused by Cu exposure via regulating DAF-16/FoxO and SKN-1/Nrf2 pathways and intestinal flora to eliminate excess ROS. Our study provides a theoretical basis formulating future strategy of probiotics against heavy metal contamination.
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