Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 16, Issue 15, Pages 1230-1243Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557516666160505115743
Keywords
Cancer; COX-2; Cyclooxygenase; Inflammation; Oncology; PGE2
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Funding
- Open Project Program of State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences [Y412201442]
- National Natural Science Fund [31300643]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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Cancer is a major cause of death worldwide despite significant advances in surgery and biology. Several recent studies have suggested that there is a close connection between tumorigenesis and inflammation. Cyclooxygenase-2 (COX-2), a link between inflammation and cancer, was proposed as a prime target for cancer therapy. However, the main available COX-2 inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), have several side effects that limit their application in cancer treatment. Additional research is needed to identify drugs that can regulate COX-2 or prostaglandin E2 (PGE2) with greater efficacy. Understanding the mechanism of COX-2/PGE2-mediated cancer and inflammation would be very useful for successful drug development. Progress of research and development into the role of COX related signaling both in inflammation and tumorigenesis in recent years has been summarized and introduced in this paper. Novel drugs designed to inhibit COX-2-related cancers are discussed to provide references for further development of novel drugs.
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