Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 16, Issue 13, Pages 1084-1097Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557516666160607230238
Keywords
Cruzipain; Galectin-3; Gp85/trans-Sialidase; Mucins; T. cruzi invasion; Toll-like receptors
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Chagas' disease is still a worldwide threat, with estimated from 6 to 7 million infected people, mainly in Latin America. Despite all efforts, especially from international consortia (DNDi, NMTrypI), to develop an innovative therapeutic strategy against this disease, no candidate has achieved full requirements for clinical use yet. In this review, we point out the general molecular and cellular mechanisms involved in T. cruzi cell invasion and elucidate the roles of specific parasite and host targets in the progress of Chagas' disease. Among these molecular targets are Gp85/transsialidase, mucins, cruzipain and oligopeptidase B, found in parasite cell surface, and Galectin-3 and Toll-like receptors present in host cells. Thus, the deep understanding of their interplay and involvement on T. cruzi host cell adhesion, invasion and evasion from host immune may expand the chances for discovering new therapeutic agents against this neglected disease. Additionally, these targets may represent a remarkable strategy to block parasite invasion in the early stages of infection.
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