4.7 Article

meso-Methylhydroxy BODIPY: a scaffold for photo-labile protecting groups

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 29, Pages 6369-6372

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc00550g

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Funding

  1. Israeli National Nanotechnology Initiative in the Focal Technology Area: Nanomedicines for Personalized Theranostics
  2. Raymond and Beverly Sackler Fund for Convergence Research (Tel Aviv University)
  3. EWM (UC Berkeley)
  4. A-STAR, Singapore Fellowship

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Here, we show that by installing a meso-methylhydroxy moiety, the boron dipyrromethene (BODIPY) scaffold can be converted into an efficient caging group, removable by green light. We describe caging and uncaging of important chemical functionalities and demonstrate green light mediated control over biological processes in cultured cell lines and neurons.

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