Polydiacetylene based colorimetric nano-sensor for on-spot detection of aflatoxin in food matrices and animal feed

Article Food Science & Technology

Maternal dietary exposure to mycotoxin aflatoxin B1 promotes intestinal immune alterations and microbiota modifications increasing infection susceptibility in mouse offspring

Patricia Bastos-Amador et al.

Summary: Maternal exposure to AFB1 may affect the intestinal barrier function of offspring and reduce their ability to cope with intestinal pathogens.

FOOD AND CHEMICAL TOXICOLOGY (2023)

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Article Environmental Sciences

MXene-based aptasensor for the detection of aflatoxin in food and agricultural products

Arpana Parihar et al.

Summary: Detection of food toxins requires sensitive and selective techniques to prevent economic loss. Nanostructured material-enabled biosensors have been developed to improve the detection of food toxins, particularly aflatoxin. Biosensor-based detection of aflatoxin is quick, affordable, and requires less skilled personnel compared to conventional techniques. MXenes and aptamers are promising elements for biosensing, offering biocompatibility, mechanical strength, selectivity, and ease of synthesis. This review explores the latest aptamer-based MXene-enabled biosensing technologies for detecting mycotoxins in food and environmental samples, discussing synthesis processes, computational approaches, and future potential. The advantages of aptasensors over conventional methods are highlighted, along with their limitations. The review emphasizes the benefits of next-generation MXene-enabled biosensing technologies in terms of simplicity, sensitivity, and selectivity, as well as their economic/commercial potential. Challenges and a roadmap for developing advanced biosensing technologies are also discussed.

ENVIRONMENTAL POLLUTION (2023)

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Article Chemistry, Applied

Dual quantum dot nanobeads-based fluorescence-linked immunosorbent assay for simultaneous detection of aflatoxin B1 and zearalenone in feedstuffs

Runxian Li et al.

Summary: A novel QBs-FLISA method was developed for simultaneous detection of AFB1 and ZEN in feedstuffs, with significantly improved detection sensitivity. Results showed good agreement between QBs-FLISA and LC-MS/MS analysis. Low detection limits and high recovery rates were achieved.

FOOD CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

Investigation of Twelve Significant Mycotoxin Contamination in Nut-Based Products by the LC-MS/MS Method

Buket Er Demirhan et al.

Summary: This study investigated the presence of mycotoxins and total aerobic mesophilic bacteria in peanut butter, hazelnut butter, and chocolate samples obtained from local markets in Ankara, Turkey. The results showed that some of the tested samples had mycotoxin levels exceeding the maximum limit set by the Turkish Food Codex. The most frequently detected mycotoxins were OTA and AFB1.

METABOLITES (2022)

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Article Food Science & Technology

Preparation of an Immunoaffinity Column Based on Bispecific Monoclonal Antibody for Aflatoxin B1 and Ochratoxin A Detection Combined with ic-ELISA

Disha Lu et al.

Summary: A novel and efficient immunoaffinity column based on bispecific monoclonal antibody recognizing AFB(1) and OTA was developed and successfully applied in the simultaneous extraction and detection of AFB(1) and OTA from food samples.

FOODS (2022)

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Article Chemistry, Applied

LC-MS/MS based appraisal of multi-mycotoxin co-occurrence in poultry feeds from different regions of Punjab, Pakistan

Asifa Sarwat et al.

Summary: Mycotoxins pose a threat to animal and human health and contribute significantly to economic losses in the poultry sector. A study conducted in Punjab, Pakistan found a co-occurrence of multiple mycotoxins and contamination in poultry feed samples, with many samples exceeding the European Commission's limits.

FOOD ADDITIVES & CONTAMINANTS PART B-SURVEILLANCE (2022)

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Article Chemistry, Analytical

Development of a biotinylated nanobody for sensitive detection of aflatoxin B1 in cereal via ELISA

Tingting Yan et al.

Summary: Aflatoxin B-1 (AFB(1)) contamination poses a significant threat to food safety and human health, requiring continuous monitoring. In this study, a biotin-streptavidin-amplified enzyme-linked immunosorbent assay (BA-ELISA) was developed for sensitive and rapid detection of AFB(1) in cereal. The BA-ELISA demonstrated improved sensitivity, reduced assay time, and significant antibody savings compared to conventional ELISA.

TALANTA (2022)

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Article Food Science & Technology

Emerging strategies in fluorescent aptasensor toward food hazard aflatoxins detection

Mengke Zhang et al.

Summary: This article provides a comprehensive review of the applications and development trends of fluorescent aptasensors for aflatoxin detection from 2018 to 2022. Fluorescent aptasensors, as a promising sensing strategy, have great potential in ensuring food safety. However, current research mainly focuses on the construction and application of simple aptasensors, and more in-depth studies on mechanism, as well as the development of miniaturized devices for point-of-care testing, should be emphasized.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Stability of DMPC Liposomes Externally Conjugated with Branched Polyglycerol

Alexander A. Beketov et al.

Summary: The structure of vesicles formed by DMPC liposomes externally conjugated with branched polyglycerol-dendrons and linear PEG in water solution was simulated using the DPD method. It was found that modification of the liposome's outer surface with hydrophilic dendrons has little effect on the vesicle's size and shape, as well as the lipid membrane's morphology, until certain critical thresholds are exceeded.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Materials Science, Multidisciplinary

Polydiacetylene-based sensors for food applications

Max Weston et al.

Summary: Polydiacetylene (PDA) sensors are developed as food management tools due to their convenient colorimetric signal, low cost, versatility, and ability to be incorporated into food packaging materials and devices. This review discusses PDA sensor fabrication methods, their application as food quality and contaminant sensors, and their integration into materials and devices. Different PDA sensor formats for food applications, including solution-based tests and substrate-based sensors like hydrogels and films, are evaluated. The challenges and opportunities for future research in PDA food sensors are also discussed.

MATERIALS ADVANCES (2022)

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Review Nanoscience & Nanotechnology

Recent Progress in Aptamer Discoveries and Modifications for Therapeutic Applications

Shuaijian Ni et al.

Summary: Aptamers, with oligonucleotide sequences, have capabilities to bind to specific target molecules and are attracting great attention in diverse clinical translations. They offer advantages such as prolonged storage life and feasibility of chemical modifications for enhancing stability.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Biophysics

Quantitative detection of aflatoxin B1 using quantum dots-based immunoassay in a recyclable gravity-driven microfluidic chip

Xinran Xiang et al.

Summary: A novel microfluidic chip was developed for rapid and sensitive detection of AFB1, showing a wide analytical range and low detection limit, as well as good specificity and reusability. The chip design provides a reliable scheme for on-site detection of AFB1 and analysis of other small molecules.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Food Science & Technology

Development of a colorimetric aptasensor for aflatoxin B1 detection based on silver nanoparticle aggregation induced by positively charged perylene diimide

Jamras Lerdsri et al.

Summary: A sensitive colorimetric aptasensor has been developed for rapid quantification of aflatoxin B1 (AfB1) based on the aggregation and localized surface plasmon resonance (LSPR) of silver nanoparticles (AgNPs). The sensor shows excellent linear response to AfB1 within the range of 0.2-6.0 ng/mL, with a detection limit of 0.09 ng/mL and high selectivity. The innovative method has been successfully applied for AfB1 determination in real samples such as peanut, corn, and chicken feed, with recoveries over 80% and RSD lower than 10%.

FOOD CONTROL (2021)

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Article Food Science & Technology

Analysis of EU Rapid Alert System (RASFF) Notifications for Aflatoxins in Exported US Food and Feed Products for 2010-2019

Ahmad Alshannaq et al.

Summary: The United States is a major exporter of various nuts, but in recent years, border rejections and notifications for U.S. tree nuts and peanuts exported to EU countries have increased due to AF contamination. The main issue lies in AF contamination in foods, especially almonds, peanuts, and pistachios.

TOXINS (2021)

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Article Chemistry, Analytical

Digital analysis of polydiacetylene quality tags for contactless monitoring of milk

Max Weston et al.

Summary: The study introduces a new composite material sensor that can provide indirect indication of food quality on food packaging without direct contact with the food. By developing a digital colorimetric analysis software and a new metric called the Digital Colorimetric Response, researchers were able to describe the polydiacetylene response with excellent linearity.

ANALYTICA CHIMICA ACTA (2021)

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Article Chemistry, Applied

Aflatoxins in foodstuffs: Occurrence and risk assessment in Turkey

Bulent Kabak

Summary: This study aimed to determine dietary exposure to aflatoxin B-1 (AFB(1)) and the sum of aflatoxins (AFT) for the Turkish population. The results showed potential health concerns for Turkish adults due to considerably low Margin of Exposure (MOE) estimates for mean and 95th percentile exposures to AFB(1).

JOURNAL OF FOOD COMPOSITION AND ANALYSIS (2021)

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Article Chemistry, Analytical

Aggregation triggered aflatoxin B1 determination in foodstuff employing 5-aminotetramethylrhodamine decorated gold-silver core-shell nanoparticles in surface enhanced Raman scattering

Tianhui Jiao et al.

Summary: This study uses a NH2-Rh-Au@Ag CSNPs sensor and Hg(II) media, utilizing SERS strategy to detect AFB1 in wheat, and the selective interaction of Hg(II) media with AFB1 inhibits the aggregation of the sensor, allowing for the quantification of AFB1 through the nanogap effect induced by aggregation.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Review Chemistry, Analytical

Recent advances in aptasensors for mycotoxin detection: On the surface and in the colloid

Nan Zhang et al.

Summary: Aptasensors show great potential in mycotoxin detection, can be divided into two types, on the surface and in the colloid, and are expected to provide inspiration for researchers in the design and development process.

TALANTA (2021)

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Article Chemistry, Applied

An innovative prussian blue nanocubes decomposition-assisted signal amplification strategy suitable for competitive lateral flow immunoassay to sensitively detect aflatoxin B1

Tong Bu et al.

Summary: The study introduces a novel prussian blue nanocubes decomposition-assisted signal amplification strategy for competitive lateral flow immunoassay, which enhances sensitivity by weakening color intensity, achieving excellent detection performance.

FOOD CHEMISTRY (2021)

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Article Food Science & Technology

Metabolic fate and toxicity reduction of aflatoxin B1 after uptake by edible Tenebrio molitor larvae

Kim Lara Guetzkow et al.

Summary: The use of insects as food and feed is gaining more attention for ecological and ethical reasons. Despite the high tolerance of edible yellow mealworm larvae to AFB1, the metabolic fate of the toxin in the insect is uncertain. Analysis showed that 87% of the ingested AFB1 remained undetected in larval body or residue, and extracts from exposed larvae did not exhibit elevated toxic potential in human liver cells as a surrogate for genotoxicity.

FOOD AND CHEMICAL TOXICOLOGY (2021)

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Article Food Science & Technology

An overview of nanomaterial based biosensors for detection of Aflatoxin B1 toxicity in foods

Neelam Yadav et al.

Summary: AFB1 is a powerful mycotoxin contaminating various foods and feeds, causing a range of health hazards. Researchers suggest that nanomaterials-based biosensors are more stable, selective, and cost-effective for detecting AFB1 toxicity. However, further studies are needed to address issues related to the stability, toxicity, and metabolic fate of these biosensors.

FOOD AND CHEMICAL TOXICOLOGY (2021)

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Article Chemistry, Analytical

A dual-colored persistent luminescence nanosensor for simultaneous and autofluorescence-free determination of aflatoxin B1 and zearalenone

Yuan-Yuan Jiang et al.

Summary: This study presents a novel nanosensor for the simultaneous detection of AFB(1) and ZEN in food samples, utilizing dual-colored persistent luminescence nanoparticles and Fe3O4 magnetic nanoparticles. The nanosensor integrates features such as autofluorescence-free detection, high specificity, and rapid magnetic separation, enabling highly sensitive and selective detection of mycotoxins. The developed technology offers a universal optical platform for the simultaneous detection of multiple contaminants in complex samples.

TALANTA (2021)

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Article Chemistry, Multidisciplinary

Outstanding Enhancement of Curcumin Fluorescence in PDDA and Silica Nanoparticles Coated DMPC Liposomes Based Nanocapsules: Application for Selective Estimation of ATP

Alaa K. Othman et al.

Summary: The study synthesized DMPC nanocapsules using nanotechnological modification of probe molecules to selectively target ATP molecules, demonstrating good stability.

CHEMISTRYSELECT (2021)

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Review Food Science & Technology

Recent Advances in Conventional Methods and Electrochemical Aptasensors for Mycotoxin Detection

Jing Yi Ong et al.

Summary: This article discusses the issues of mycotoxins in food and feed, emphasizing the importance of early detection as a cost-effective method for ensuring food safety. The development of biosensors, including affinity columns and aptasensors, for the quantitative analysis of mycotoxins is highlighted. The review also covers the advancements in electrochemical transducers and aptasensors, with a brief introduction to commercially available mycotoxin detection kits.

FOODS (2021)

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Article Chemistry, Applied

Development and validation of a rapid and efficient method for simultaneous determination of mycotoxins in coix seed using one-step extraction and UHPLC-HRMS

Yu Wu et al.

Summary: Coix seed, an important food and traditional Chinese medicine in China and other Asian countries, is being used for COVID-19 treatment in China, but is at risk of mycotoxin contamination. A newly developed method for detecting 24 mycotoxins in coix seeds highlighted the need for routine monitoring and control of these contaminants.

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT (2021)

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Article Biochemical Research Methods

An aptamer affinity column for purification and enrichment of aflatoxin B1 and aflatoxin B2 in agro-products

Hongmei Liu et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

Aptamer-Conjugated Polydiacetylene Colorimetric Paper Chip for the Detection of Bacillus thuringiensis Spores

Chaoge Zhou et al.

SENSORS (2020)

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Naked-Eye Detection of Ethylene Using Thiol-Functionalized Polydiacetylene-Based Flexible Sensors

Long H. Nguyen et al.

ACS SENSORS (2020)

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Article Chemistry, Applied

Ionic liquid functionalized zinc oxide nanorods for solid-phase microextraction of aflatoxins in food products

Meseret Amde et al.

JOURNAL OF FOOD COMPOSITION AND ANALYSIS (2020)

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Article Biochemical Research Methods

Analysis of multiple mycotoxins-contaminated wheat by a smart analysis platform

Changrui Xing et al.

ANALYTICAL BIOCHEMISTRY (2020)

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Article Food Science & Technology

Quantitative analysis and dietary risk assessment of aflatoxins in Chinese post-fermented dark tea

Pu Cui et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

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Article Materials Science, Multidisciplinary

Polydiacetylene for the Detection of α-Hemolysin in Milk toward the Diagnosis of Bovine Mastitis

Max Weston et al.

ACS APPLIED POLYMER MATERIALS (2020)

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Review Polymer Science

Tuning chromatic response, sensitivity, and specificity of polydiacetylene-based sensors

Max Weston et al.

POLYMER CHEMISTRY (2020)

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Risk assessment of aflatoxins in food

Dieter Schrenk et al.

EFSA JOURNAL (2020)

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Trophic transfer, bioaccumulation, and biomagnification of non-essential hazardous heavy metals and metalloids in food chains/webs-Concepts and implications for wildlife and human health

Hazrat Ali et al.

HUMAN AND ECOLOGICAL RISK ASSESSMENT (2019)

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Polydiacetylene (PDA) Liposome-Based Immunosensor for the Detection of Exosomes

Changheon Kim et al.

BIOMACROMOLECULES (2019)

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Purification and identification of an aflatoxin B1 degradation enzyme from Pantoea sp. T6

Yanli Xie et al.

TOXICON (2019)

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Mycotoxins in food and feed

Jelka Pleadin et al.

ADVANCES IN FOOD AND NUTRITION RESEARCH, VOL 89 (2019)

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Smartphone-Based VOC Sensor Using Colorimetric Polydiacetylenes

Dong-Hoon Park et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Review Food Science & Technology

Mycotoxins and beer. Impact of beer production process on mycotoxin contamination. A review

Xenia Pascari et al.

FOOD RESEARCH INTERNATIONAL (2018)

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Polydiacetylene Supramolecules: Synthesis, Characterization, and Emerging Applications

Jessica T. Wen et al.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2018)

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Qingqing Meng et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Polydiacetylene liposomes with phenylboronic acid tags: a fluorescence turn-on sensor for sialic acid detection and cell-surface glycan imaging

Dong-En Wang et al.

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A competitive immunoassay using hapten-modified polydiacetylene vesicles for homogeneous and sensitive detection of sodium benzoate

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An On-Site Simultaneous Semi-Quantification of Aflatoxin B1, Zearalenone, and T-2 Toxin in Maize- and Cereal-Based Feed via Multicolor Immunochromatographic Assay

Lin Xu et al.

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Manuela Petaccia et al.

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Sangwan Kim et al.

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Influence of EDC/NHS coupling chemistry on stability and cytotoxicity of ZnO nanoparticles modified with proteins

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Ultra-high-pressure liquid chromatography-solid-phase clean-up for determining aflatoxins in Egyptian food commodities

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Sensitivity limitation of the sensor fabricated with polydiacetylene

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Behaviour of polydiacetylene vesicles under different conditions of temperature, pH and chemical components of milk

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Assessment of the bioaccessibility of aflatoxins from various food matrices using an in vitro digestion model, and the efficacy of probiotic bacteria in reducing bioaccessibility

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)

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Polydiacetylene based colorimetric nano-sensor for on-spot detection of aflatoxin in food matrices and animal feed

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