Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 220, Issue 11, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20231501
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Several species generate their preimmune repertoire in gut-associated lymphoid tissues (GALT) and diversify it through gene conversion and/or somatic hypermutation, enabling immune responses against systemic antigens. Similar processes occur in T-independent B cell responses in humans.
Several species generate their preimmune repertoire in gut-associated lymphoid tissues (GALT), compensating a reduced germline V gene repertoire by post-rearrangement diversification mechanisms (gene conversion and/or somatic hypermutation) in these environments that act as primary lymphoid organs. We summarize here these processes for three different species (chickens, sheep, and rabbits) and further discuss the analogous process that T-independent B cell responses in humans represent: we indeed recently showed that response against bacterial polysaccharides mobilize marginal zone B cells that prediversified against gut antigens. While the initial diversification strategy differs in these two cases, i.e., repertoire formation driven by gut-derived mitotic signals vs. response against gut antigens, the common feature of these two processes is the mobilization of a B cell compartment prediversified in GALT for immune responses against distinct systemic antigens.
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