☆ 4.7 Review

Imaging plant metabolism in situ

JOURNAL OF EXPERIMENTAL BOTANY (2023)

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Tracking Spatial Distribution Alterations of Multiple Endogenous Molecules during Lentil Germination by MALDI Mass Spectrometry Imaging

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Leaves of Cannabis sativa and their trichomes studied by DESI and MALDI mass spectrometry imaging for their contents of cannabinoids and flavonoids

Marcus Daniel Brandbjerg Bohn Lorensen et al.

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Mass spectrometry imaging techniques: a versatile toolbox for plant metabolomics

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Metabolic profiling, in-situ spatial distribution, and biosynthetic pathway of functional metabolites in Dendrobium nobile stem revealed by combining UPLC-QTOF-MS with MALDI-TOF-MSI

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MALDI Imaging Assisted Discovery of a Di-O-glycosyltransferase from Platycodon grandiflorum Root

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Using mass spectrometry imaging to map fluxes quantitatively in the tumor ecosystem

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Chemical imaging reveals diverse functions of tricarboxylic acid metabolites in root growth and development

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NATURE COMMUNICATIONS (2023)

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FRONTIERS IN PLANT SCIENCE (2023)

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Article Plant Sciences

Unveiling the spatial distribution and molecular mechanisms of terpenoid biosynthesis in Salvia miltiorrhiza and S. grandifolia using multi-omics and DESI-MSI

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HORTICULTURE RESEARCH (2023)

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MALDI MSI and Raman Spectroscopy Application in the Analysis of the Structural Components and Flavonoids in Brassica napus Stem

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How to sample a seizure plant: the role of the visualization spatial distribution analysis of Lophophora williamsii as an example

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FORENSIC SCIENCES RESEARCH (2023)

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Spatially resolved metabolomics combined with bioactivity analyses to evaluate the pharmacological properties of two Radix Puerariae species

Na Guo et al.

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JOURNAL OF ETHNOPHARMACOLOGY (2023)

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Mass spectrometry imaging and single-cell transcriptional profiling reveal the tissue-specific regulation of bioactive ingredient biosynthesis in Taxus leaves

Xiaori Zhan et al.

Summary: In this study, the tissue-specific distribution and transcriptional regulation of active metabolites in Taxus leaves were explored using single-cell sequencing and mass spectrometry imaging. The results revealed a high degree of cell heterogeneity in Taxus leaves and identified several novel and cell-specific transcription factors involved in secondary metabolite biosynthesis.

PLANT COMMUNICATIONS (2023)

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Article Engineering, Environmental

Elucidating Drought-Tolerance Mechanisms in Plant Roots through 1H NMR Metabolomics in Parallel with MALDI-MS, and NanoSIMS Imaging Techniques

Linnea K. Honeker et al.

Summary: This study examined the effects of drought on root metabolic profiles and carbon allocation pathways of three tropical rainforest species. The results showed that drought had species-specific impacts on metabolic profiles and spatial distribution in different plants. The presence of microbial also influenced root metabolic pathways.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

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Article Chemistry, Analytical

Biosynthesis-based spatial metabolome of Salvia miltiorrhiza Bunge by combining metabolomics approaches with mass spectrometry-imaging

Qi Tong et al.

Summary: The study successfully revealed the spatial distributions of different metabolites in the roots and aerial parts of Salvia miltiorrhiza through untargeted metabolomics research and mass spectrometry imaging, providing important insights for understanding the biosynthesis of bioactive metabolites in plants.

TALANTA (2022)

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Review Chemistry, Multidisciplinary

Advances in MALDI Mass Spectrometry Imaging Single Cell and Tissues

Xiaoping Zhu et al.

Summary: Compared with conventional optical microscopy techniques, mass spectrometry imaging (MSI) is a powerful label-free analytical technique that can detect, quantify, and map multiple biomolecules in cells and tissues. Matrix-assisted laser desorption/ionization (MALDI) is the most commonly used MSI scanning method.

FRONTIERS IN CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

Mass Spectrometry Imaging Disclosed Spatial Distribution of Defense-Related Metabolites in Triticum spp.

Laura Righetti et al.

Summary: By investigating the tissue distribution of defense metabolites in two Triticum species, this study reveals the spatial distribution of wheat defense metabolites, providing important clues for understanding their functional role.

METABOLITES (2022)

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Complex Changes in Membrane Lipids Associated with the Modification of Autophagy in Arabidopsis

Yosia Mugume et al.

Summary: This study investigated the impact of autophagy on plant lipid content and composition using Arabidopsis mutants. The results showed that autophagy affects plant lipid concentrations and properties such as chain length and unsaturation.

METABOLITES (2022)

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FT-ICR Mass Spectrometry Imaging at Extreme Mass Resolving Power Using a Dynamically Harmonized ICR Cell with 1ω or 2ω Detection

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ANALYTICAL CHEMISTRY (2022)

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Article Pharmacology & Pharmacy

Visualizing the spatial distribution and alteration of metabolites in continuously cropped Salvia miltiorrhiza Bge using MALDI-MSI

Chenglong Sun et al.

Summary: This study investigated the spatial location and variation of endogenous metabolites in continuously cropped Salvia miltiorrhiza Bge (SMB) roots using matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). The results showed that continuous cropping led to lower expression levels of tanshinones, salvianolic acids, polyamines, and oligosaccharides in SMB roots. However, there was little difference in the expressions of caffeic acid and salvianolic acid A. Ferulic acid was more widely distributed in continuously cropped SMB.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2022)

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Review Microbiology

The Rhizosphere Microbiome of Ginseng

Paul H. Goodwin

Summary: The rhizosphere of ginseng contains a wide range of microorganisms that can have beneficial or harmful effects on the plant. Cultivation practices that mimic natural conditions of ginseng may disrupt soil microbiome, leading to negative changes in soil physiochemistry and promotion of plant diseases. However, beneficial microbes isolated from the ginseng rhizosphere show potential to improve ginseng production. High-throughput sequencing has greatly expanded our knowledge of the diversity and abundance of rhizosphere organisms and their impacts on cultivation.

MICROORGANISMS (2022)

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Article Agriculture, Multidisciplinary

Visualizing the Distribution of Phthalate Esters and Plant Metabolites in Carrot by Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

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Article Plant Sciences

A mass spectrometry imaging approach on spatiotemporal distribution of multiple alkaloids in Gelsemium elegans

Zi-Han Wu et al.

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FRONTIERS IN PLANT SCIENCE (2022)

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Fully Automated Unconstrained Analysis of High-Resolution Mass Spectrometry Data with Machine Learning

Daniil A. Boiko et al.

Summary: Mass spectrometry is a convenient, sensitive, and reliable method for analyzing complex mixtures, with applications in materials science, life sciences, and chemistry. However, accurately assigning signals in complex mixtures remains a challenge. This study presents a novel approach using gradient-boosted decision trees and neural networks to generate molecular formulas from mass spectrometry data, providing a detailed analysis.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Effective Mechanisms for Improving Seed Oil Production in Pennycress (Thlaspi arvense L.) Highlighted by Integration of Comparative Metabolomics and Transcriptomics

Christopher Johnston et al.

Summary: Pennycress is a promising biofuel crop with high content of long-chain unsaturated fatty acids, and it achieves efficient oil production through non-conventional pathways. Metabolic engineering can improve pennycress oilseed content and make it a economically viable source of aviation fuel.

FRONTIERS IN PLANT SCIENCE (2022)

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Article Plant Sciences

Desorption Electrospray Ionization Mass Spectrometry Imaging Illustrates the Quality Characters of Isatidis Radix

Li-Xing Nie et al.

Summary: This study applied the combination of DESI and Q-TOF/MS to reveal the comprehensive spatial distribution of metabolites in Isatidis Radix and illustrate its quality characters. Using ion images and pattern recognition method, samples with different quality characters were distinguished, and 11 potential quality markers were identified. DESI-MSI, together with chemometric analysis, can improve the understanding of herbal medicine biology and help in quality control.

FRONTIERS IN PLANT SCIENCE (2022)

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Review Oncology

Comparing DESI-MSI and MALDI-MSI Mediated Spatial Metabolomics and Their Applications in Cancer Studies

Michelle Junyi He et al.

Summary: Metabolic heterogeneity of cancer has significant impact on its treatment outcomes and prognosis. Spatial metabolomics using mass spectrometry imaging technology has shown promise in studying altered metabolites in cancer patients, allowing for successful classification of cancer tissue subtypes and identification of distribution trends of key metabolites.

FRONTIERS IN ONCOLOGY (2022)

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Article Chemistry, Medicinal

Visualizing the spatial distribution of functional metabolites in Forsythia suspensa at different harvest stages by MALDI mass spectrometry imaging

Fengtang Jing et al.

Summary: The study for the first time used MALDI-MSI to reveal the spatial distribution and growth patterns of metabolites in different parts of Forsythia suspensa, indicating the importance of mesocarp and endosperm tissues in storing important functional metabolites.

FITOTERAPIA (2022)

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Article Agricultural Engineering

In-situ detection and imaging of Areca catechu fruit alkaloids by MALDI-MSI

Jiao Wu et al.

Summary: Arecoline, a prevalent alkaloid in areca fruits, is considered the fourth most consumed addictive drug globally. This study utilized multiple techniques to analyze the alkaloids in areca fruits and provided information on their distribution in different tissues, contributing to the optimal utilization of areca fruits.

INDUSTRIAL CROPS AND PRODUCTS (2022)

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Article Biochemistry & Molecular Biology

Study on the Distribution of Low Molecular Weight Metabolites in Mango Fruit by Air Flow-Assisted Ionization Mass Spectrometry Imaging

Deqing Zhao et al.

Summary: Mass spectrometry imaging is a rapidly developing molecular imaging technique. Air flow-assisted ionization mass spectrometry imaging (AFAI-MSI) has gained attention in the biomedical field for its features such as high sensitivity and wide coverage of metabolite detection without the need for sample pretreatment. This study established a mass spectrometry imaging method for analyzing low molecular metabolites in mango fruits using the AFAI-MSI method. The distribution of various compounds in mango tissue was analyzed, providing a convenient and direct approach for the analysis of endogenous metabolites in mango fruits.

MOLECULES (2022)

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Review Chemistry, Analytical

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) for in situ analysis of endogenous small molecules in biological samples

Huihui Liu et al.

Summary: This paper provides an overview of the importance of endogenous small molecules in biological processes and their relevance to various diseases. It highlights the use of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) as a powerful tool for analyzing small molecules in situ. The paper discusses the workflow, applications, challenges, and future directions of MALDI-MSI for small molecule analysis.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2022)

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Article Plant Sciences

Grapevine leaf MALDI-MS imaging reveals the localisation of a putatively identified sucrose metabolite associated to Plasmopara viticola development

Marisa Maia et al.

Summary: This study successfully localized the molecules involved in the initial moments of grapevine-Plasmopara viticola interaction using MSI and found their accumulation on the veins. This provides important clues for further understanding the infection mechanism of P. viticola.

FRONTIERS IN PLANT SCIENCE (2022)

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Review Biochemistry & Molecular Biology

Image to insight: exploring natural products through mass spectrometry imaging

Yonghui Dong et al.

Summary: This article provides an overview of the application of mass spectrometry imaging (MSI) in natural product (NP) research, with a focus on recent advances in plants and microorganisms. The potential of combining MSI with other imaging modalities and stable isotope labeling is discussed. The article also highlights the strengths and weaknesses of MSI and suggests future improvements for routine NP studies. Lastly, new research areas, future perspectives, and the overall direction of the field are discussed.

NATURAL PRODUCT REPORTS (2022)

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Article Plant Sciences

Biofortified tomatoes provide a new route to vitamin D sufficiency

Jie Li et al.

Summary: Vitamin D insufficiency is a significant public health issue, and this study has successfully engineered tomato lines that accumulate provitamin D-3, providing a new dietary source and the potential for supplement production.

NATURE PLANTS (2022)

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Review Chemistry, Physical

Quantitative Mass Spectrometry Imaging of Biological Systems

Daisy Unsihuay et al.

Summary: Mass spectrometry imaging (MSI) is a powerful label-free technique that can provide detailed maps of hundreds of molecules in complex samples with high sensitivity and subcellular spatial resolution. Accurate quantification in MSI requires a detailed understanding of matrix effects, extraction efficiency, and mass-dependent ion losses. Approaches developed for quantitative MSI of metabolites, lipids, and proteins in biological tissues are discussed for current and future applications.

ANNUAL REVIEW OF PHYSICAL CHEMISTRY, VOL 72 (2021)

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Article Biochemistry & Molecular Biology

Mass spectrometry imaging of phosphatidylcholine metabolism in lungs administered with therapeutic surfactants and isotopic tracers

Shane R. Ellis et al.

Summary: In this study, mass spectrometry imaging with high mass resolution and stable isotope labeling was used to analyze spatial distribution of phosphatidylcholine (PC) metabolism in mouse lungs, revealing dysregulated surfactant metabolism and turnover of therapeutic pulmonary surfactants. The dual labeling strategy demonstrated lack of inhibition of endogenous PC synthesis by exogenous surfactant and showed the location of acyl chain remodeling processes leading to formation of polyunsaturated PC lipids. This ability to visualize discrete metabolic events has potential applications in both clinical and experimental studies.

JOURNAL OF LIPID RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Localization of Major Ephedra Alkaloids in Whole Aerial Parts of Ephedrae Herba Using Direct Analysis in Real Time-Time of Flight-Mass Spectrometry

Nayoung Yun et al.

Summary: Mass spectrometry-based molecular imaging, particularly using DART-TOF-MS, has provided a novel approach for macro-scale imaging of whole plants, revealing spatial distribution of major ephedra alkaloids in Ephedrae Herba. The study found higher alkaloid concentrations in the inner section of stems compared to the outer surface, with side branches showing significantly higher alkaloid content than the main stem, indicating a gradient decrease of alkaloids towards branch tips.

MOLECULES (2021)

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Article Plant Sciences

Where do the electrons go? How numerous redox processes drive phytochemical diversity Redox processes in phytochemistry

Patrick J. Horn

Summary: Plants produce diverse metabolites through complex redox reactions and components, crucial for adapting to dynamic environments. The key role of oxidoreductases in plant physiological processes deserves further exploration. Adverse environmental conditions in the future may escalate oxidative damage, necessitating the development of new protection strategies.

PHYTOCHEMISTRY REVIEWS (2021)

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Article Biotechnology & Applied Microbiology

Production of tocotrienols in seeds of cotton (Gossypium hirsutum L.) enhances oxidative stability and offers nutraceutical potential

Shanmukh S. Salimath et al.

Summary: Upland cotton is an economically important crop globally cultivated for various purposes. Transgenic cotton lines expressing a barley gene showed increased accumulation of vitamin E without negative impacts on plant performance; in fact, it enhanced antioxidant activity and oxidative stability of cottonseed oil, potentially providing new opportunities for improved cottonseed co-products.

PLANT BIOTECHNOLOGY JOURNAL (2021)

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Article Plant Sciences

Unveiling the spatial distribution of aflatoxin B1 and plant defense metabolites in maize using AP-SMALDI mass spectrometry imaging

Laura Righetti et al.

Summary: This study used advanced imaging technology to investigate the response of maize plants to aflatoxin B1, revealing that AFB1 had the most significant impact on anthocyanin biosynthesis and chlorophyll metabolism in roots, while also triggering a series of biochemical responses in above-ground organs.

PLANT JOURNAL (2021)

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Article Plant Sciences

Visualizing vinca alkaloids in the petal of Catharanthus roseus using functionalized titanium oxide nanowire substrate for surface-assisted laser desorption/ionization imaging mass spectrometry

Ewelina P. Dutkiewicz et al.

Summary: Imaging mass spectrometry (IMS) is a powerful technique for analyzing various molecular species with high spatial resolution and low detection limits. Functionalized TiO2 nanowire substrate-based surface-assisted laser desorption/ionization (SALDI) is an effective complementary technique to MALDI-MS for detecting low-molecular-weight species in plant tissues.

PLANT JOURNAL (2021)

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Review Biochemical Research Methods

Applications of stable isotopes in MALDI imaging: current approaches and an eye on the future

Angus C. Grey et al.

Summary: Matrix-assisted laser desorption/ionisation-imaging mass spectrometry (MALDI-IMS) is a valuable imaging modality in the study of biological, biomedical and pathological processes. The use of stable isotopically labelled (SIL) compounds in MALDI-IMS helps to overcome technical barriers and enhance accuracy and versatility. Studies delivering SIL compounds to live tissues provide insights into cell, tissue and inter-tissue metabolism while maintaining spatial resolution.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Applied

MALDI-TOF/TOF tandem mass spectrometry imaging reveals non-uniform distribution of disaccharide isomers in plant tissues

Lingpeng Zhan et al.

Summary: Mass spectrometry imaging (MSI) is a powerful technique for studying biomolecular locations in tissues, but often struggles to differentiate isomeric compounds. Coupling tandem mass spectrometry with MSI can help differentiate isomers effectively. This study utilized MALDI-TOF/TOF tandem mass spectrometry imaging to successfully differentiate isomeric disaccharides in plant tissues, highlighting the importance of considering isobaric compounds in research.

FOOD CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Analyzing Mass Spectrometry Imaging Data of 13C-Labeled Phospholipids in Camelina sativa and Thlaspi arvense (Pennycress) Embryos

Trevor B. Romsdahl et al.

Summary: The combination of C-13-isotopic labeling and mass spectrometry imaging offers a method to analyze metabolic flux, but presents technical challenges. Results from studying embryos of oilseed crops show greater C-13-isotopic labeling in cotyledons, with isotopic enrichment in PC molecular species suggesting different flux patterns related to fatty acid pathways.

METABOLITES (2021)

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Editorial Material Plant Sciences

Editorial: Amino Acids in Plants: Regulation and Functions in Development and Stress Defense

Maurizio Trovato et al.

FRONTIERS IN PLANT SCIENCE (2021)

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Article Chemistry, Applied

Visualizing the distribution of strawberry plant metabolites at different maturity stages by MALDI-TOF imaging mass spectrometry

Jin Wang et al.

Summary: This study visualized differences in the distribution of citric acid, soluble sugars, and anthocyanins in strawberries at different maturity stages using MALDI-TOF IMS. Results showed anthocyanins mainly located in the periphery of fruit, and the sugar content increased significantly in red strawberries. Absolute quantitation from HPLC analyses supported the quantitative results from MALDI-TOF IMS.

FOOD CHEMISTRY (2021)

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Article Biochemical Research Methods

Analysis of Erythroxylum coca Leaves by Imaging Mass Spectrometry (MALDI-FT-ICR IMS)

Nayara Araujo dos Santos et al.

Summary: Using MALDI IMS, this study analyzed the distribution of alkaloids on the surface of coca leaves, with 2,5-dihydroxybenzoic acid (DHB) identified as the most efficient matrix at 2 mg/mL. Washing the leaves with organic solvents did not improve ionization performance. The inner part of the leaf tissue was studied using a 50 μm thick tissue section, revealing the presence of alkaloids and flavonoid molecules.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2021)

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Article Plant Sciences

Unveiling spatial metabolome of Paeonia suffruticosa and Paeonia lactiflora roots using MALDI MS imaging

Bin Li et al.

Summary: This study performed high mass resolution MALDI MSI and MALDI tandem MSI on the root sections of Paeonia suffruticosa and Paeonia lactiflora to characterize the spatial distributions of various metabolites. The technique successfully distinguished the tissue distribution of isomers and provided comprehensive spatial information on metabolites, which could enhance our understanding of biosynthetic pathways and ensure the safety and efficacy of medicinal use.

NEW PHYTOLOGIST (2021)

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Article Plant Sciences

Mass spectrometry-based quantification and spatial localization of small organic acid exudates in plant roots under phosphorus deficiency and aluminum toxicity

David Gomez-Zepeda et al.

Summary: Low-molecular-weight organic acid (OA) extrusion by plant roots plays a critical role in plant nutrition, tolerance to cations toxicity, and plant-microbe interactions. This study developed two complementary methodologies for OA determination, which were used to evaluate the effect of inorganic ortho-phosphate (Pi) deficiency and aluminum toxicity on OA excretion by Arabidopsis roots. The quantification of six OAs in root exudates and the spatial location of citric and malic acid in roots and exudates were successfully achieved using targeted ultra-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UPLC-HRMS/MS) and targeted matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI).

PLANT JOURNAL (2021)

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Review Plant Sciences

Mechanisms and functions of membrane lipid remodeling in plants

Linhui Yu et al.

Summary: Lipid remodeling, defined as post-synthetic modifications of membrane lipids, plays a crucial role in regulating cellular membrane properties and functions. Processes affected by lipid remodeling include lipid metabolism, membrane repair, cellular homeostasis, fatty acid trafficking, cellular signaling, and stress tolerance. Recent research focuses on understanding the mechanisms of membrane lipid remodeling, particularly the enzymes involved in modifying major membrane lipids such as phosphatidylcholine and monogalactosyldiacylglycerol.

PLANT JOURNAL (2021)

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Article Plant Sciences

Visualizing the distributions and spatiotemporal changes of metabolites in Panax notoginseng by MALDI mass spectrometry imaging

Chenglong Sun et al.

Summary: A highly sensitive MALDI-MS imaging method was developed to visualize the spatial distributions and spatiotemporal changes of metabolites in different botanical parts of Panax notoginseng. Metabolites that changed during the steaming of Panax notoginseng were successfully screened and imaged, enhancing our understanding of its metabolic networks.

JOURNAL OF GINSENG RESEARCH (2021)

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Article Biotechnology & Applied Microbiology

Maldi-mass Spectrometry Imaging for Phytoalexins Detection in RD6 Thai Rice

S. Komkleow et al.

Summary: The study successfully detected diterpenoid phytoalexins in Thai rice using MALDI-MSI, revealing five types of phytoalexins in RD6 rice and demonstrating its resistance to blast disease. This technology offers new opportunities for agricultural applications in the future.

APPLIED BIOCHEMISTRY AND MICROBIOLOGY (2021)

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Review Agronomy

Toward sustainable production of value-added bioenergy and industrial oils in oilseed and biomass feedstocks

Kiyoul Park et al.

Summary: Plant fatty acids play important roles in food, feed, fuel, and industrial materials, with unusual or specialized fatty acids found in diverse seed oils. These fatty acids have potential as biofuels and industrial feedstocks due to their diverse structures and properties.

GLOBAL CHANGE BIOLOGY BIOENERGY (2021)

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Article Biochemistry & Molecular Biology

Plant Metabolic Network 15: A resource of genome-wide metabolism databases for 126 plants and algae

Charles Hawkins et al.

Summary: The research team created metabolic pathway databases of 126 plant and algal genomes, improving quality through a semi-automated validation process. They compared metabolic content across organisms, identifying distinct metabolic groups, and demonstrated the utility of the resource in plant biology research.

JOURNAL OF INTEGRATIVE PLANT BIOLOGY (2021)

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Article Chemistry, Analytical

Mass spectrometry imaging for direct visualization of components in plants tissues

Wenya Hu et al.

Summary: Mass spectrometry imaging is an important analytical technique in plant science that can determine molecular compositions and spatial distributions simultaneously, aiding in understanding the functions and regulatory pathways of components in plants. Despite facing challenges and technical barriers, significant progress has been made in areas such as tissue preparation improvement, matrix innovation, and ionization mode development.

JOURNAL OF SEPARATION SCIENCE (2021)

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Article Biochemical Research Methods

Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

Saleh Alseekh et al.

Summary: Compound identification and reliable quantification in metabolomics are complicated by the chemical complexity and dynamic range of the metabolome, while quantification in complex mixtures can be further complicated by ion suppression and the presence of isomers.

NATURE METHODS (2021)

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Article Pharmacology & Pharmacy

Microscopic Mass Spectrometry Imaging Reveals the Distribution of Phytochemicals in the Dried Root of Isatis tinctoria

Li-Xing Nie et al.

Summary: This study utilized microscopic mass spectrometry imaging to reveal the distribution of phytochemicals in the dried root of Isatis tinctoria, visualizing the locations of some metabolites for the first time. Based on mass spectrometry imaging, samples collected from different habitats were differentiated unambiguously.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Adhesive film applications help to prepare strawberry fruit sections for desorption electrospray ionization-mass spectrometry imaging

Hirofumi Enomoto

Summary: DESI-MSI is a powerful tool for analyzing the distribution of metabolites in biological tissues, and cryosectioning using transparent adhesive films can improve the analysis of metabolites in strawberry fruits and other plant tissues. The study demonstrated that adhesive film-prepared cryosections maintained original structures, allowing for the visualization of amino acids, sugars, organic acids, and flavonoids in the tissues.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2021)

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Article Plant Sciences

Phosphorus deprivation affects composition and spatial distribution of membrane lipids in legume nodules

Dhiraj Dokwal et al.

Summary: Phosphorus (P) is an essential macronutrient for symbiotic nitrogen fixation (SNF) in legumes, and its deficiency can impair SNF activity and affect the accumulation of phosphate in roots and nodules. Under P deficiency conditions, membrane lipids in nodules exhibit changes, with alterations in the distribution of phospholipids (PL) species. Specific phosphatidylcholine (PC) species in nodules may play different roles in response to P stress, leading to heterogeneous distribution within nodules.

PLANT PHYSIOLOGY (2021)

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Article Plant Sciences

The GORKY glycoalkaloid transporter is indispensable for preventing tomato bitterness

Yana Kazachkova et al.

Summary: By studying nine bitter-tasting accessions, including the 'high tomatine' Peruvian landraces, researchers found a deletion in the GORKY gene, which mediates the subcellular localization of alpha-tomatine during fruit ripening; GORKY exports alpha-tomatine and its derivatives from the vacuole to the cytosol, facilitating the conversion of the entire alpha-tomatine pool to non-bitter forms; these findings suggest that GORKY activity is a notable innovation in the process of tomato fruit domestication and breeding.

NATURE PLANTS (2021)

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Article Cell Biology

Coupling APEX labeling to imaging mass spectrometry of single organelles reveals heterogeneity in lysosomal protein turnover

Derek P. Narendra et al.

JOURNAL OF CELL BIOLOGY (2020)

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Review Spectroscopy

Unsupervised machine learning for exploratory data analysis in imaging mass spectrometry

Nico Verbeeck et al.

MASS SPECTROMETRY REVIEWS (2020)

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Article Agriculture, Multidisciplinary

Imaging Study by Mass Spectrometry of the Spatial Variation of Cellulose and Hemicellulose Structures in Corn Stalks

B. Arnaud et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Chemistry, Physical

Nanoparticle-immersed paper imprinting mass spectrometry imaging reveals uptake and translocation mechanism of pesticides in plants

Xinzhou Wu et al.

NANO RESEARCH (2020)

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Article Biochemical Research Methods

MALDI-HRMS imaging and HPLC-HRESI-MSn characterisation of kaurane diterpenes in the fruits of Xylopia aethiopica (Dunal) A. Rich (Annonaceae)

James Oppong Kyekyeku et al.

PHYTOCHEMICAL ANALYSIS (2020)

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Article Food Science & Technology

Spermidine and other functional phytochemicals in soybean seeds: Spatial distribution as visualized by mass spectrometry imaging

Tatsuya Sagara et al.

FOOD SCIENCE & NUTRITION (2020)

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Review Plant Sciences

Exploring Uncharted Territories of Plant Specialized Metabolism in the Postgenomic Era

Joseph R. Jacobowitz et al.

ANNUAL REVIEW OF PLANT BIOLOGY, VOL 71, 2020 (2020)

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Article Agriculture, Multidisciplinary

Imaging of Multiple Plant Hormones in Roots of Rice (Oryza sativa) Using Nanoparticle-Assisted Laser Desorption/Ionization Mass Spectrometry

Katsuhiro Shiono et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

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Article Plant Sciences

Involvement of BGLU30 in Glucosinnlate Catabolism in the Arabidopsis Leaf under Dark Conditions

Tomomi Morikawa-Ichinose et al.

PLANT AND CELL PHYSIOLOGY (2020)

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Article Plant Sciences

Metabolomic profiling of wild-type and mutant soybean root nodules using laser-ablation electrospray ionization mass spectrometry reveals altered metabolism

Beverly J. Agtuca et al.

PLANT JOURNAL (2020)

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Article Plant Sciences

Visualizing Genotypic and Developmental Differences of Free Amino Acids in Maize Roots With Mass Spectrometry Imaging

Kelly C. O'Neill et al.

FRONTIERS IN PLANT SCIENCE (2020)

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Article Multidisciplinary Sciences

The genome of jojoba (Simmondsia chinensis): A taxonomically isolated species that directs wax ester accumulation in its seeds

Drew Sturtevant et al.

SCIENCE ADVANCES (2020)

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Review Biochemical Research Methods

Tracing metabolic flux through time and space with isotope labeling experiments

Doug K. Allen et al.

CURRENT OPINION IN BIOTECHNOLOGY (2020)

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Article Multidisciplinary Sciences

Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity

Yang Zhang et al.

ISCIENCE (2020)

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Article Plant Sciences

High mass resolution, spatial metabolite mapping enhances the current plant gene and pathway discovery toolbox

Yonghui Dong et al.

NEW PHYTOLOGIST (2020)

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Article Multidisciplinary Sciences

Mass spectrometry imaging as a potential technique for diagnostic of Huanglongbing disease using fast and simple sample preparation

Joao Guilherme de Moraes Pontes et al.

SCIENTIFIC REPORTS (2020)

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Article Chemistry, Applied

Localization Analysis of Multiple Vitamins in Dried Persimmon (Diospyros kaki) Using Matrix-assisted Laser Desorption/ionization Mass Spectrometry Imaging

Hitomi Shikano et al.

JOURNAL OF OLEO SCIENCE (2020)

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Article Biochemistry & Molecular Biology

Visualization of soluble carbohydrate distribution in apple fruit flesh utilizing MALDI-TOF MS imaging

Kentaro Horikawa et al.

PLANT SCIENCE (2019)

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Article Biochemistry & Molecular Biology

Mass spectrometry imaging of low molecular weight metabolites in strawberry fruit (Fragaria x ananassa Duch.) cv. Primoris with 109Ag nanoparticle enhanced target

Joanna Niziol et al.

PHYTOCHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

UPLC and ESI-MS analysis of metabolites of Rauvolfia tetraphylla L. and their spatial localization using desorption electrospray ionization (DESI) mass spectrometric imaging

P. Mohana Kumara et al.

PHYTOCHEMISTRY (2019)

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Article Chemistry, Analytical

Matrix-Assisted Laser Desorption Ionization Imaging and Laser Ablation Sampling for Analysis of Fungicide Distribution in Apples

Igor Pereira et al.

ANALYTICAL CHEMISTRY (2019)

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Article Agriculture, Multidisciplinary

Mass Spectrometry Imaging of the Spatial and Temporal Localization of Alkaloids in Nightshades

Hanna Bednarz et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

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Article Plant Sciences

Quinolizidine alkaloids are transported to seeds of bitter narrow-leafed lupin

Sophie Lisa Otterbach et al.

JOURNAL OF EXPERIMENTAL BOTANY (2019)

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Article Biochemical Research Methods

Transmission-mode MALDI-2 mass spectrometry imaging of cells and tissues at subcellular resolution

M. Niehaus et al.

NATURE METHODS (2019)

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Review Chemistry, Analytical

Recent advances in ambient mass spectrometry imaging

Jinjuan Xue et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

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Article Endocrinology & Metabolism

Tissue-specific differences in metabolites and transcripts contribute to the heterogeneity of ricinoleic acid accumulation in Ricinus communis L. (castor) seeds

Drew Sturtevant et al.

METABOLOMICS (2019)

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Review Plant Sciences

Exploring the Diversity of Plant Metabolism

Chuanying Fang et al.

TRENDS IN PLANT SCIENCE (2019)

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Review Chemistry, Analytical

Biological explorations with nanoscale secondary ion mass spectrometry

Frank Gyngard et al.

JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY (2019)

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Article Chemistry, Analytical

LDI and MALDI-FT-ICR imaging MS in Cannabis leaves: optimization and study of spatial distribution of cannabinoids

Nayara A. dos Santos et al.

ANALYTICAL METHODS (2019)

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Article Biochemical Research Methods

MSiReader v1.0: Evolving Open-Source Mass Spectrometry Imaging Software for Targeted and Untargeted Analyses

Mark T. Bokhart et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2018)

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Article Endocrinology & Metabolism

High-mass-resolution MALDI mass spectrometry imaging reveals detailed spatial distribution of metabolites and lipids in roots of barley seedlings in response to salinity stress

Lenin D. Sarabia et al.

METABOLOMICS (2018)

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Review Biochemical Research Methods

Recent advances in matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) for in situ analysis of endogenous molecules in plants

Liang Qin et al.

PHYTOCHEMICAL ANALYSIS (2018)

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Article Biotechnology & Applied Microbiology

Identification of bottlenecks in the accumulation of cyclic fatty acids in camelina seed oil

Xiao-Hong Yu et al.

PLANT BIOTECHNOLOGY JOURNAL (2018)

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Article Plant Sciences

Interrogation of spatial metabolome of Ginkgo biloba with high-resolution matrix-assisted laser desorption/ionization and laser desorption/ionization mass spectrometry imaging

Bin Li et al.

PLANT CELL AND ENVIRONMENT (2018)

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Article Plant Sciences

Spatial analysis of lipid metabolites and expressed genes reveals tissue-specific heterogeneity of lipid metabolism in high- and low-oil Brassica napus L. seeds

Shaoping Lu et al.

PLANT JOURNAL (2018)

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Article Plant Sciences

Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus

Allison M. Heskes et al.

PLANT JOURNAL (2018)

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Review Chemistry, Multidisciplinary

Polyamines: Bio-Molecules with Diverse Functions in Plant and Human Health and Disease

Avtar K. Handa et al.

FRONTIERS IN CHEMISTRY (2018)

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Article Plant Sciences

PlantFAdb: a resource for exploring hundreds of plant fatty acid structures synthesized by thousands of plants and their phylogenetic relationships

John Ohlrogge et al.

PLANT JOURNAL (2018)

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Article Chemistry, Multidisciplinary

High-Spatial Resolution Mass Spectrometry Imaging: Toward Single Cell Metabolomics in Plant Tissues

Rebecca L. Hansen et al.

CHEMICAL RECORD (2018)

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Review Chemistry, Analytical

Mass Spectrometry Imaging: A Review of Emerging Advancements and Future Insights

Amanda Rae Buchberger et al.

ANALYTICAL CHEMISTRY (2018)

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Article Multidisciplinary Sciences

Tailoring seed oil composition in the real world: optimising omega-3 long chain polyunsaturated fatty acid accumulation in transgenic Camelina sativa

Sarah Usher et al.

SCIENTIFIC REPORTS (2017)

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Article Biochemistry & Molecular Biology

Three-dimensional visualization of membrane phospholipid distributions in Arabidopsis thaliana seeds: A spatial perspective of molecular heterogeneity

Drew Sturtevant et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2017)

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Review Biochemical Research Methods

Recent advances in stable isotope-enabled mass spectrometry-based plant metabolomics

Dana M. Freund et al.

CURRENT OPINION IN BIOTECHNOLOGY (2017)

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Review Plant Sciences

Mass spectrometry imaging for plant biology: a review

Berin A. Boughton et al.

PHYTOCHEMISTRY REVIEWS (2016)

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Review Biochemical Research Methods

Matrix assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) for direct visualization of plant metabolites in situ

Drew Sturtevant et al.

CURRENT OPINION IN BIOTECHNOLOGY (2016)

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Review Multidisciplinary Sciences

The plant lipidome in human and environmental health

Patrick J. Horn et al.

SCIENCE (2016)

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Review Plant Sciences

Sample Preparation for Mass Spectrometry Imaging of Plant Tissues: A Review

Yonghui Bong et al.

FRONTIERS IN PLANT SCIENCE (2016)

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Article Plant Sciences

Organic Acids: The Pools of Fixed Carbon Involved in Redox Regulation and Energy Balance in Higher Plants

Abir U. Igamberdiev et al.

FRONTIERS IN PLANT SCIENCE (2016)

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Article Biochemical Research Methods

A derivatization and validation strategy for determining the spatial localization of endogenous amine metabolites in tissues using MALDI imaging mass spectrometry

M. Lisa Manier et al.

JOURNAL OF MASS SPECTROMETRY (2014)

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Review Biochemical Research Methods

Extraction for Metabolomics: Access to The Metabolome

Mian Yahya Mushtaq et al.

PHYTOCHEMICAL ANALYSIS (2014)

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Review Biochemistry & Molecular Biology

Lipidomics in situ: Insights into plant lipid metabolism from high resolution spatial maps of metabolites

Patrick J. Horn et al.

PROGRESS IN LIPID RESEARCH (2014)

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Article Plant Sciences

Imaging heterogeneity of membrane and storage lipids in transgenic Camelina sativa seeds with altered fatty acid profiles

Patrick J. Horn et al.

PLANT JOURNAL (2013)

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Article Biochemistry & Molecular Biology

Spatial Mapping of Lipids at Cellular Resolution in Embryos of Cotton

Patrick J. Horn et al.

PLANT CELL (2012)

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Review Plant Sciences

Use of mass spectrometry for imaging metabolites in plants

Young Jin Lee et al.

PLANT JOURNAL (2012)

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Review Plant Sciences

Vitamins in plants: occurrence, biosynthesis and antioxidant function

M. Amparo Asensi-Fabado et al.

TRENDS IN PLANT SCIENCE (2010)

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