Exosomal long noncoding RNA MLETA1 promotes tumor progression and metastasis by regulating the miR-186-5p/EGFR and miR-497-5p/IGF1R axes in non-small cell lung cancer

Article Biochemistry & Molecular Biology

A novel long noncoding RNA SP100-AS1 induces radioresistance of colorectal cancer via sponging miR-622 and stabilizing ATG3

You Zhou et al.

Summary: The SP100-AS1/miR-622/ATG3 axis plays a crucial role in radioresistance and autophagic activity in colorectal cancer, indicating its potential as a therapeutic target to improve the response to radiation therapy.

CELL DEATH AND DIFFERENTIATION (2023)

Add to Collection

Article Oncology

Kremen2 drives the progression of non-small cell lung cancer by preventing SOCS3-mediated degradation of EGFR

Yuxiao Sun et al.

Summary: This study found that Kremen2 is highly expressed in non-small cell lung cancer (NSCLC) and is associated with poor prognosis. Inhibition of Kremen2 reduces cell proliferation and migration ability. Further mechanistic studies revealed that Kremen2 interacts with SOCS3 to stabilize epidermal growth factor receptor (EGFR), promoting activation of the PI3K-AKT and JAK2-STAT3 signaling pathways.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2023)

Add to Collection

Article Oncology

The β-catenin-LINC00183-miR-371b-5p-Smad2/LEF1 axis promotes adult T-cell lymphoblastic lymphoma progression and chemoresistance

Wei-Juan Huang et al.

Summary: This study investigates the role of lncRNA LINC00183 in the progression and chemoresistance of adult T-cell lymphoblastic lymphoma (T-LBL). The results show that LINC00183 is upregulated in T-LBL and is associated with poor prognosis and chemoresistance. The study also reveals a feedback loop involving LINC00183, miR-371b-5p, Smad2, and LEF1, which promotes T-LBL progression and chemoresistance. These findings suggest that LINC00183 could be a potential therapeutic target for T-LBL.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2023)

Add to Collection

Article Oncology

LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization

Nasha Zhang et al.

Summary: In this study, a new long non-coding RNA (lncRNA), LINC00240, was discovered to be transcribed from the 6p22.1 gastric cancer risk locus and function as an oncogene. LINC00240 was found to be highly expressed in gastric cancer specimens and associated with poor patient survival. Additionally, LINC00240 was shown to promote malignant proliferation, migration, and metastasis of gastric cancer cells. Importantly, LINC00240 stabilized the oncoprotein DDX21 by enhancing its interaction with its novel deubiquitinating enzyme USP10, thereby promoting gastric cancer progression.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2023)

Add to Collection

Article Oncology

Cancer statistics, 2023

Rebecca L. Siegel et al.

Summary: The American Cancer Society predicts that there will be 1,958,310 new cancer cases and 609,820 cancer deaths in the United States in 2023. While incidence trends for most cancers are favorable, prostate cancer saw a significant increase of 3% annually from 2014 to 2019. However, the overall cancer death rate continues to decline due to advances in treatment, with a 33% reduction since 1991.

CA-A CANCER JOURNAL FOR CLINICIANS (2023)

Add to Collection

Article Multidisciplinary Sciences

Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression

Meiyan Qi et al.

Summary: The formation of pre-metastatic niche is a critical step in breast cancer metastasis. Lin28B plays a crucial role in promoting lung metastasis of breast cancer by establishing an immune-suppressive pre-metastatic niche.

NATURE COMMUNICATIONS (2022)

Add to Collection

Review Pharmacology & Pharmacy

Adverse Drug Reactions and Toxicity of the Food and Drug Administration-Approved Antisense Oligonucleotide Drugs

Feryal Alhamadani et al.

Summary: This paper provides a comprehensive analysis of the unique and common adverse drug reactions (ADRs) and toxicity of FDA-approved ASO drugs. The information can help manage the risk of severe hepatotoxicity, kidney toxicity, and hypersensitivity reactions in the usage of currently approved ASO drugs and the discovery and development of new and safer ASO drugs.

DRUG METABOLISM AND DISPOSITION (2022)

Add to Collection

Review Oncology

LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond

Wanxu Huang et al.

Summary: DNA methylation is a crucial epigenetic mechanism that regulates gene expression, and aberrant patterns of DNA methylation are associated with human diseases such as cancer. This review provides an overview of the current understanding of long non-coding RNA (lncRNA)-mediated DNA methylation, with a focus on its roles in cancer. The potential clinical applications of this mechanism in RNA-targeting drug development are also discussed.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis

Song-Tao Xue et al.

Summary: ESCC was found to have dysregulated expression of lncRNAs, with LINC00680 being highly expressed and associated with poor prognosis. LINC00680 acts as a ceRNA by sponging miR-423-5p to regulate PAK6 expression in ESCC cells, suggesting its potential as a diagnostic, prognostic, and therapeutic target for ESCC.

MOLECULAR CANCER (2022)

Add to Collection

Article Biochemistry & Molecular Biology

GIPC2 interacts with Fzd7 to promote prostate cancer metastasis by activating WNT signaling

Liang Wang et al.

Summary: High expression of GIPC2 is significantly associated with distant metastasis and poor prognosis in prostate cancer. GIPC2, as an exosomal molecule, promotes metastatic capabilities of prostate cancer cells. By binding to the WNT co-receptor, GIPC2 activates WNT signaling pathway, thereby stimulating prostate cancer metastasis.

ONCOGENE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer

Xue Wang et al.

Summary: DLGAP1-AS2 promotes tumorigenesis and metastasis in colorectal cancer by interacting with ELOA and degrading ELOA. It also decreases LHPP expression by inhibiting ELOA-mediated transcriptional activation, thus blocking LHPP-dependent suppression of the AKT signaling pathway. DLGAP1-AS2 is bound and stabilized by CPSF2 and CSTF3.

MOLECULAR CANCER (2022)

Add to Collection

Article Biochemistry & Molecular Biology

CircVAPA promotes small cell lung cancer progression by modulating the miR-377-3p and miR-494-3p/IGF1R/AKT axis

Jinghan Hua et al.

Summary: circVAPA promotes the progression of small cell lung cancer through the miR-377-3p and miR-494-3p/IGF1R/AKT axis.

MOLECULAR CANCER (2022)

Add to Collection

Article Biochemistry & Molecular Biology

IGF1R acts as a cancer-promoting factor in the tumor microenvironment facilitating lung metastasis implantation and progression

Elvira Alfaro-Arnedo et al.

Summary: IGF1R plays a crucial role in lung cancer by promoting tumor growth, metastasis, and progression. It may also serve as a potential biomarker for drug response and clinical evolution in NSCLC patients.

ONCOGENE (2022)

Add to Collection

Article Oncology

EGFR amplification is a putative resistance mechanism for NSCLC-LM patients with TKI therapy and is associated with poor outcome

Hainan Yang et al.

Summary: This study suggests that EGFR gene amplification may be a potential resistance mechanism to EGFR-TKI treatment failure in NSCLC-LM patients and is associated with inferior clinical outcomes.

FRONTIERS IN ONCOLOGY (2022)

Add to Collection

Article Oncology

MNX1-AS1 Promotes Phase Separation of IGF2BP1 to Drive c-Myc-Mediated Cell-Cycle Progression and Proliferation in Lung Cancer

Qingqing Zhu et al.

Summary: This study reveals that the lncRNA MNX1-AS1 upregulates c-Myc and E2F1 signaling by driving phase separation of IGF2BP1, leading to enhanced cell-cycle progression and proliferation in NSCLC.

CANCER RESEARCH (2022)

Add to Collection

Article Oncology

Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis

Shengkui Qiu et al.

Summary: This study found that miR-519a-3p expression levels in exosomes were higher in gastric cancer liver metastasis (GC-LM) patients, and high expression indicated a worse prognosis. GC-derived exosomes mainly accumulated in the liver and were internalized by intrahepatic macrophages. Further research revealed that miR-519a-3p activated the MAPK/ERK pathway by targeting DUSP2, inducing M2-like polarization of macrophages and promoting angiogenesis and intrahepatic premetastatic niche formation. These findings suggest that miR-519a-3p plays a critical role in the interaction between primary GC cells and intrahepatic macrophages.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Add to Collection

Article Oncology

LncRNA FAM83H-AS1 promotes the malignant progression of pancreatic ductal adenocarcinoma by stabilizing FAM83H mRNA to protect β-catenin from degradation

Min Zhou et al.

Summary: FAM83H-AS1 is highly expressed in PDAC patients and is associated with shorter survival. It promotes the proliferation, invasion, and metastasis of PDAC cells by protecting FAM83H mRNA from degradation. FAM83H protein has similar functions as FAM83H-AS1 in PDAC cells and can bind to beta-catenin, activating the Wnt/beta-catenin signaling pathway.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Add to Collection

Article Biochemistry & Molecular Biology

LINC00941promotes CRC metastasis through preventing SMAD4 protein degradation and activating the TGF-β/SMAD2/3 signaling pathway

Nan Wu et al.

Summary: LINC00941 plays a crucial role in metastatic colorectal cancer by activating the TGF-beta/SMAD2/3 pathway to promote metastasis and invasion.

CELL DEATH AND DIFFERENTIATION (2021)

Add to Collection

Review Pharmacology & Pharmacy

Antisense Drugs Make Sense for Neurological Diseases

C. Frank Bennett et al.

Summary: ASOs represent a promising therapeutic platform for treating neurodegenerative diseases by targeting RNA. Approval of nusinersen in 2016 demonstrated that effective treatments for neurodegenerative diseases can be identified. Several antisense drugs are in late-stage research for various neurological diseases, showing potential for long-term effects and symptom improvement.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021 (2021)

Add to Collection

Review Cell Biology

LNCcation: lncRNA localization and function

Mary Catherine Bridges et al.

Summary: This review summarizes the current knowledge of subcellular localization of long noncoding RNAs (lncRNAs), factors controlling their localization, emerging themes, and discusses the implications of lncRNA localization on their function and cellular behavior, as well as opportunities for future research.

JOURNAL OF CELL BIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Intercellular transfer of exosomal wild type EGFR triggers osimertinib resistance in non-small cell lung cancer

Shaocong Wu et al.

Summary: The study found that intercellular transfer of exosomal wild type EGFR protein could induce osimertinib resistance in EGFR-mutated sensitive cancer cells. Additionally, osimertinib promoted the release of exosomes by upregulating a Rab GTPase (RAB17), which may be one of the mechanisms underlying drug resistance.

MOLECULAR CANCER (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Antisense oligonucleotides: absorption, distribution, metabolism, and excretion

Mohammad Shadid et al.

Summary: Understanding the ADME properties of existing ASOs can lead to further improvements in this cutting-edge therapy, allowing researchers to safely develop ASO drugs and enhance their ability to innovate.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2021)

Add to Collection

Review Cell Biology

Gene regulation by long non-coding RNAs and its biological functions

Luisa Statello et al.

Summary: Recent studies have shed new light on the biogenesis and functions of long non-coding RNAs (lncRNAs), showcasing their diverse roles in gene regulation and signaling pathways, particularly in the contexts of neuronal disorders, immune responses, and cancer. The discovery of unique biogenesis pathways and subcellular localizations of lncRNAs has opened up potential therapeutic avenues for targeting lncRNAs in various biological and pathophysiological conditions.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Add to Collection

Review Biotechnology & Applied Microbiology

Pharmacokinetics and Proceedings in Clinical Application of Nucleic Acid Therapeutics

Markus Herkt et al.

Summary: Oligonucleotide therapeutics are a promising class of drugs targeting RNA molecules to revolutionize disease treatment. Through chemical modifications for stability and binding, these drugs show potential in treating neurodegenerative, cardiac, and cancer disorders. With ongoing research and development, these oligonucleotide-based agents are paving the way for next-generation therapeutics.

MOLECULAR THERAPY (2021)

Add to Collection

Article Oncology

CD151 drives cancer progression depending on integrin α3β1 through EGFR signaling in non-small cell lung cancer

Jianjie Zhu et al.

Summary: The study demonstrated that high expression of CD151 in NSCLC tissues and cell lines is associated with poor prognosis, and its overexpression promotes tumor proliferation, migration, and invasion. CD151 regulates downstream signaling pathways and affects the sensitivity of NSCLC cells to anti-cancer drugs by interacting with integrins and activating the EGFR/ErbB2 signaling pathway.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Add to Collection

Review Medicine, Research & Experimental

The role of exosomes in lung cancer metastasis and clinical applications: an updated review

Lei Yin et al.

Summary: Exosomes play a crucial role in lung cancer metastasis by promoting various processes such as cell proliferation, angiogenesis, and immune evasion. They are also being explored as potential therapeutic drug carriers and predictive biomarkers for diagnosing, prognosis, and anti-tumor drug resistance in lung cancer.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Tumor-associated exosomes promote lung cancer metastasis through multiple mechanisms

Chunyang Jiang et al.

Summary: Exosomes play a crucial role in the communication between tumor cells and their microenvironment, especially in the development of lung cancer metastasis. Studies have shown that tumor-derived exosomes promote lung cancer via processes such as inducing epithelial-mesenchymal transition. Understanding these mechanisms provides researchers with new ideas to explore clinical applications for the diagnosis and treatment of lung cancer metastasis.

MOLECULAR CANCER (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The ELF3-regulated lncRNA UBE2CP3 is over-stabilized by RNA-RNA interactions and drives gastric cancer metastasis via miR-138-5p/ITGA2 axis

Dandan Li et al.

Summary: The overexpression of lncRNA UBE2CP3 in gastric cancer promotes tumor progression through modulation of the miR-138-5p/ITGA2 axis. This suggests that UBE2CP3 may serve as a potential therapeutic target in gastric cancer.

ONCOGENE (2021)

Add to Collection

Article Multidisciplinary Sciences

Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer

Kerui Wu et al.

Summary: Bone metastasis is a major complication of breast cancer, with ER+ tumors having a higher incidence of bone metastasis than ER- tumors. This study identifies that miR-19a and IBSP from bone-tropic ER+ breast cancer cells cooperatively induce osteoclastogenesis and promote bone colonization.

NATURE COMMUNICATIONS (2021)

Add to Collection

Review Oncology

Long noncoding RNAs in cancer metastasis

S. John Liu et al.

Summary: Long noncoding RNAs play crucial roles in promoting metastasis by participating in discrete pro-metastatic steps and influencing the metastatic tumor microenvironment. They have the potential for diagnostic and therapeutic applications, but also face controversies and ongoing technical challenges. Further research is needed to explore their mechanisms and potential as targets for novel therapies in cancer metastasis.

NATURE REVIEWS CANCER (2021)

Add to Collection

Article Medicine, Research & Experimental