Related references
Note: Only part of the references are listed.Imatinib facilitates gemcitabine sensitivity by targeting epigenetically activated PDGFC signaling in pancreatic cancer
Yin-Hao Shi et al.
MOLECULAR THERAPY (2023)
N6-methyladenosine demethylase FTO enhances chemo-resistance in colorectal cancer through SIVA1-mediated apoptosis
Ziyou Lin et al.
MOLECULAR THERAPY (2023)
Cancer statistics, 2023
Rebecca L. Siegel et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2023)
The role of m6A demethylase FTO in chemotherapy resistance mediating acute myeloid leukemia relapse
Zhi-Wei Zhang et al.
CELL DEATH DISCOVERY (2023)
Online adaptive MR-guided stereotactic radiotherapy for unresectable malignancies in the upper abdomen using a 1.5T MR-linac
Lois A. Daamen et al.
ACTA ONCOLOGICA (2022)
Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL-Specific Degrader DT2216
Dinesh Thummuri et al.
MOLECULAR CANCER THERAPEUTICS (2022)
Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer
Jianyou Gu et al.
MOLECULAR CANCER (2022)
RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m6A-YTHDF2-dependent manner
Zhen Tan et al.
ONCOGENE (2022)
FTO promotes colorectal cancer progression and chemotherapy resistance via demethylating G6PD/PARP1
Jiyan Wang et al.
CLINICAL AND TRANSLATIONAL MEDICINE (2022)
MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro
Meiling Chen et al.
CELLS (2022)
HIF-1α-regulated stanniocalcin-1 mediates gemcitabine resistance in pancreatic ductal adenocarcinoma via PI3K/AKT signaling pathway
Fangyu Zhao et al.
MOLECULAR CARCINOGENESIS (2022)
Senescent neutrophils-derived exosomal piRNA-17560 promotes chemoresistance and EMT of breast cancer via FTO-mediated m6A demethylation
Baochi Ou et al.
CELL DEATH & DISEASE (2022)
Berberine Overcomes Gemcitabine-Associated Chemoresistance through Regulation of Rap1/PI3K-Akt Signaling in Pancreatic Ductal Adenocarcinoma
Keisuke Okuno et al.
PHARMACEUTICALS (2022)
A PLCB1-PI3K-AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression
Shuhang Liang et al.
CANCER RESEARCH (2021)
LncRNA HIF1A-AS1 Promotes Gemcitabine Resistance of Pancreatic Cancer by Enhancing Glycolysis through Modulating the AKT/YB1/HIF1α Pathway
Fengyu Xu et al.
CANCER RESEARCH (2021)
Regulatory role and mechanism of m6A RNA modification in human metabolic diseases
Yuliang Zhang et al.
MOLECULAR THERAPY-ONCOLYTICS (2021)
Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Benoit Thibault et al.
EMBO MOLECULAR MEDICINE (2021)
A comprehensive review of m6A/m6Am RNA methyltransferase structures
Stephanie Oerum et al.
NUCLEIC ACIDS RESEARCH (2021)
Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin
Yan Wang et al.
BIOENGINEERED (2021)
The role of m6A modification in the biological functions and diseases
Xiulin Jiang et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)
The epitranscriptome beyond m6A
David Wiener et al.
NATURE REVIEWS GENETICS (2021)
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling
Bo Tang et al.
MOLECULAR CANCER (2020)
Abnormality of m6A mRNA Methylation Is Involved in Alzheimer's Disease
Min Han et al.
FRONTIERS IN NEUROSCIENCE (2020)
Ubiquitin-specific protease 7 is a druggable target that is essential for pancreatic cancer growth and chemoresistance
Hao Chen et al.
INVESTIGATIONAL NEW DRUGS (2020)
m6A-binding proteins: the emerging crucial performers in epigenetics
Yanchun Zhao et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)
RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner
Xingya Guo et al.
MOLECULAR CANCER (2020)
The potential role of RNA N6-methyladenosine in Cancer progression
Tianyi Wang et al.
MOLECULAR CANCER (2020)
PI(3,4)P2 Signaling in Cancer and Metabolism
Luca Gozzelino et al.
FRONTIERS IN ONCOLOGY (2020)
Identification of m6A-related genes and m6A RNA methylation regulators in pancreatic cancer and their association with survival
Yan Geng et al.
ANNALS OF TRANSLATIONAL MEDICINE (2020)
FTO-Dependent N6-Methyladenosine Regulates Cardiac Function During Remodeling and Repair
Prabhu Mathiyalagan et al.
CIRCULATION (2019)
PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression
Mi Kyung Park et al.
NATURE COMMUNICATIONS (2019)
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia
Yue Huang et al.
CANCER CELL (2019)
USP7: Structure, substrate specificity, and inhibition
Alexandra Pozhidaeva et al.
DNA REPAIR (2019)
Class II PI3K Functions in Cell Biology and Disease
Federico Gulluni et al.
TRENDS IN CELL BIOLOGY (2019)
Chemoresistance in Pancreatic Cancer
Siyuan Zeng et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasion
Tianfang Xia et al.
PATHOLOGY RESEARCH AND PRACTICE (2019)
Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation
Yan Xing et al.
BREAST CANCER RESEARCH (2019)
MK-2206, an allosteric inhibitor of AKT, stimulates LDLR expression and LDL uptake: A potential hypocholesterolemic agent
Katrine Bjune et al.
ATHEROSCLEROSIS (2018)
Mechanism of N6-methyladenosine modification and its emerging role in cancer
Sicong Zhang
PHARMACOLOGY & THERAPEUTICS (2018)
Emerging insights into HAUSP (USP7) in physiology, cancer and other diseases
Seemana Bhattacharya et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2018)
Patterns, Timing, and Predictors of Recurrence Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma
Vincent P. Groot et al.
ANNALS OF SURGERY (2018)
DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer
S. Hernandez-Perez et al.
ONCOGENE (2017)
Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer
Huake Sun et al.
TUMOR BIOLOGY (2017)
The PI3K Pathway in Human Disease
David A. Fruman et al.
CELL (2017)
NEDD4 is involved in acquisition of epithelial-mesenchymal transition in cisplatin-resistant nasopharyngeal carcinoma cells
Shaoyan Feng et al.
CELL CYCLE (2017)
USP7 deubiquitinase controls HIV-1 production by stabilizing Tat protein
Amjad Ali et al.
BIOCHEMICAL JOURNAL (2017)
Current standards and new innovative approaches for treatment of pancreatic cancer
Thierry Conroy et al.
EUROPEAN JOURNAL OF CANCER (2016)
miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR-p-PI3K/AKT-c-JUN
Mengyang Zhao et al.
NATURE COMMUNICATIONS (2016)
Gemcitabine resistance in pancreatic ductal adenocarcinoma
Yoav Binenbaum et al.
DRUG RESISTANCE UPDATES (2015)
Decreased N-6-Methyladenosine in Peripheral Blood RNA From Diabetic Patients Is Associated With FTO Expression Rather Than ALKBH5
Fan Shen et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)
The potential utility of geminin as a predictive biomarker in breast cancer
Sreekumar Sundara Rajan et al.
BREAST CANCER RESEARCH AND TREATMENT (2014)
Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells
Yan-Cong Li et al.
CANCER LETTERS (2014)
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry
Martin E. Hess et al.
NATURE NEUROSCIENCE (2013)
Transcriptome-wide mapping of N6-methyladenosine by m6A-seq based on immunocapturing and massively parallel sequencing
Dan Dominissini et al.
NATURE PROTOCOLS (2013)
MicroRNA-gene signaling pathways in pancreatic cancer
Dimitrios Iliopoulos et al.
Biomedical Journal (2013)
Stromal biology and therapy in pancreatic cancer
Albrecht Neesse et al.
GUT (2011)
Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis
Alyssa L. Kennedy et al.
MOLECULAR CELL (2011)
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Guifang Jia et al.
NATURE CHEMICAL BIOLOGY (2011)
Overexpression of Fto leads to increased food intake and results in obesity
Chris Church et al.
NATURE GENETICS (2010)
Prolonged versus standard gemcitabine infusion: Translation of molecular pharmacology to new treatment strategy
Stephan A. Veltkamp et al.
ONCOLOGIST (2008)
AKT/PKB signaling: Navigating downstream
Brendan D. Manning et al.
CELL (2007)
The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways
D Masuya et al.
JOURNAL OF PATHOLOGY (2006)
Tyrosine kinase inhibitors and gemcitabine: New treatment options in pancreatic cancer?
Axel Kleespies et al.
DRUG RESISTANCE UPDATES (2006)
PI3K mediates protection against TRAIL-induced apoptosis in primary human melanocytes
L Larribere et al.
CELL DEATH AND DIFFERENTIATION (2004)
Determinants of resistance to 2′,2′-difluorodeoxycytidine (gemcitabine)
AM Bergman et al.
DRUG RESISTANCE UPDATES (2002)
Share Paper
