Deciphering anti-benign prostatic hyperplasia potential of liangwanoside II based on metabolite profile characterization combined with targeted network pharmacology

Article Plant Sciences

Flavonoids derived from Anemarrhenae Rhizoma ameliorate inflammation of benign prostatic hyperplasia via modulating COX/LOX pathways

Xiaotong Cao et al.

Summary: The study showed that Anemarrhenae Rhizoma flavonoids can inhibit BPH-related inflammation by regulating AA metabolism and interfering with COX and LOX pathways.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Agriculture, Multidisciplinary

Chemical Characterization and Potential Mechanism of the Anti-Asthmatic Activity of a Subfraction from Schisandra chinensis Fruit Extract

Bin Li et al.

Summary: The study found that PET2, a subfraction of the extract from Schisandra chinensis fruit, exhibited significant anti-inflammatory effects and potential anti-asthma properties. Six compounds from PET2 were identified to have good anti-inflammatory properties, possibly through the involvement of specific signaling pathways.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

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Article Plant Sciences

Therapeutic role of Glycyrrhiza Uralensis fisher on benign prostatic hyperplasia through 5 alpha reductase regulation and apoptosis

Ja Yeon Park et al.

Summary: This study found that a water extract of Glycyrrhiza uralensis Fischer has potential therapeutic effects on BPH by inhibiting AR-5AR2 signaling and activating apoptosis signaling to reduce BPH development. Unlike finasteride, GUWE does not impact sperm count, suggesting lower toxicity and a safer alternative option for BPH treatment.

PHYTOMEDICINE (2022)

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Article Plant Sciences

0 Total glycosides from stems of Cistanche tubulosa alleviate depression-like behaviors: bidirectional interaction of the phytochemicals and gut microbiota

Li Fan et al.

Summary: The study found that total glycosides (TG) from Cistanche tubulosa are primarily responsible for its antidepressant activity, potentially through the bidirectional interaction of phytochemicals and gut microbiota, highlighting the advantage of Cistanche tubulosa in depression treatment.

PHYTOMEDICINE (2021)

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Article Plant Sciences

Effects of Saussurea costus on apoptosis imbalance and inflammation in benign prostatic hyperplasia

Do-Hyun Choi et al.

Summary: Saussurea costus may prevent and treat benign prostatic hyperplasia by modulating inflammation and apoptosis imbalance. The study demonstrated its efficacy in treating BPH, which could be a new therapeutic option.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Integrative & Complementary Medicine

Chemical profiles of the active fraction from Prinsepia utilis Royle leaves and its anti-benign prostatic hyperplasia evaluation in animal models

Ying Peng et al.

Summary: The study identified the chemical ingredients of Fr. B from Prinsepia utilis Royle leaves using UPLC-QTOF-MS, and quantified them by HPLC. Results showed that Fr. B significantly reduced VEGF and MDA levels, while increasing SOD, GSH-Px, and CAT levels in the prostate tissue of BPH rats. Additionally, Fr. B reduced DHT, DHT/E2 ratio, and TNF-alpha levels, while increasing T levels in the blood serum. Flavonoids were identified as key constituents of Fr. B, supporting its potential as a candidate for BPH treatment.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2021)

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Article Agriculture, Multidisciplinary