4.7 Article

Amorphous metal-organic frameworks for drug delivery

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 73, Pages 13878-13881

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc05237h

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Funding

  1. Becas Chile
  2. Cambridge Trust
  3. Trinity Hall (University of Cambridge)
  4. Royal Society (UK)
  5. European Research Council

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We report the encapsulation of the hydrophilic model molecule calcein in the Zr-based MOF UiO-66, followed by amorphization of the framework by ball-milling. We show controlled release of calcein over more than 30 days, compared with the 2 day release period from crystalline UiO-66.

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