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Islet cells in human type 1 diabetes: from recent advances to novel therapies - a symposium-based roadmap for future research

Journal

JOURNAL OF ENDOCRINOLOGY
Volume 259, Issue 1, Pages -

Publisher

BIOSCIENTIFICA LTD
DOI: 10.1530/JOE-23-0082

Keywords

islet; pancreas; insulin secretion; autoimmune; diabetes

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This article provides an overview of the main themes discussed at the JDRF-DiabetesUK-INNODIA-nPOD symposium in Stockholm, Sweden, highlighting promising conclusions and key unmet needs in achieving better approaches to prevent or reverse T1D.
There is a growing understanding that the early phases of type 1 diabetes (T1D) are characterised by a deleterious dialogue between the pancreatic beta cells and the immune system. This, combined with the urgent need to better translate this growing knowledge into novel therapies, provided the background for the JDRF-DiabetesUK-INNODIA-nPOD symposium entitled 'Islet cells in human T1D: from recent advances to novel therapies', which took place in Stockholm, Sweden, in September 2022. We provide in this article an overview of the main themes addressed in the symposium, pointing to both promising conclusions and key unmet needs that remain to be addressed in order to achieve better approaches to prevent or reverse T1D.

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