Engineered exosomes for cancer theranostics: Next-generation tumor targeting

Exosomes are multivesicular bodies of which the plasma membrane fuse to release the caring moiety into the surrounding body fluids. They are well knwon for their function in mediating intercellular connectivity by transferring various biomolecules, such as proteins, RNAs, and lipids, from one cell to another. These naturally equipped nanovesicles could be therapeutically targeted or engineered as drug delivery systems. The use of exosomes in cancer detection and prognosis has attracted a great deal of interest from academics. In addition to chemical, biological, and genetic engineering approaches, other current exosomal alteration methodologies hold promise for the advancement of therapeutic medicines for cancer. In this review, we highlight the theranostic potential of exosomes for therapeutic delivery in various cancers.

Automated summary

Exosomes are multivesicular bodies that release their cargo into surrounding body fluids by fusing with the plasma membrane. They transfer various biomolecules between cells, making them potential therapeutic drug delivery systems. The use of exosomes for cancer detection and prognosis has gained considerable interest. In addition to existing engineering approaches, novel methodologies for exosomal alteration show promise in advancing therapeutic medicines for cancer. This review highlights the theranostic potential of exosomes in various types of cancer.