4.7 Article

Real-time monitoring of the mitophagy process by a photostable fluorescent mitochondrion-specific bioprobe with AIE characteristics

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 43, Pages 9022-9025

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc02486b

Keywords

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Funding

  1. National Basic Research Program of China (973 Program) [2013CB834701]
  2. University Grants Committee of Hong Kong [AoE/P-03/08]
  3. Research Grants Council of Hong Kong [16301614, 16305014, N_HKUST604/14]
  4. Innovation and Technology Commission [ITCPD/17-9]
  5. Guangdong Innovative Research Team Program of China [201101C0105067115]

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An isothiocyanate-functionalized tetraphenylethene is synthesized and used as a fluorescent bioprobe for mitochondrion imaging with high specificity and photostability. The covalent conjugation of the bioprobe to mitochondrial proteins endows it with high resistance to microenvironmental changes, enabling it for real-time monitoring of mitophagy.

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